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HOXB9 homeobox B9 [ Homo sapiens (human) ]

Gene ID: 3219, updated on 26-May-2016
Official Symbol
HOXB9provided by HGNC
Official Full Name
homeobox B9provided by HGNC
Primary source
HGNC:HGNC:5120
See related
Ensembl:ENSG00000170689 HPRD:00852; MIM:142964; Vega:OTTHUMG00000159907
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOX2; HOX2E; HOX-2.5
Summary
This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer. [provided by RefSeq, Jul 2008]
Orthologs
Location:
17q21.3
Exon count:
3
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (48615128..48626473, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (46698518..46703835, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene homeobox B7 Neighboring gene homeobox B8 Neighboring gene uncharacterized LOC105371810 Neighboring gene uncharacterized LOC101060400 Neighboring gene microRNA 196a-1 Neighboring gene uncharacterized LOC105371809

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
embryonic skeletal system development IEA
Inferred from Electronic Annotation
more info
 
mammary gland development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
Preferred Names
homeobox protein Hox-B9
Names
homeo box 2E
homeo box B9
homeobox protein Hox-2.5
homeobox protein Hox-2E

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024017.4NP_076922.1  homeobox protein Hox-B9

    See identical proteins and their annotated locations for NP_076922.1

    Status: REVIEWED

    Source sequence(s)
    AK056123, AK056414, BC015565, BX114117, CA426693, DA696753, DA712230
    Consensus CDS
    CCDS11534.1
    UniProtKB/Swiss-Prot
    P17482
    UniProtKB/TrEMBL
    B3KPJ1
    Related
    ENSP00000309439, OTTHUMP00000216946, ENST00000311177, OTTHUMT00000358101
    Conserved Domains (2) summary
    cd00086
    Location:186244
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04617
    Location:1172
    Hox9_act; Hox9 activation region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    48615128..48626473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524728.1XP_011523030.1  

    Conserved Domains (1) summary
    pfam04617
    Location:1172
    Hox9_act; Hox9 activation region

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    46764512..46769829 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)