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CG1578 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32135, updated on 4-Apr-2024

Summary

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Official Symbol
CG1578provided by FlyBase
Primary source
FLYBASE:FBgn0030336
Locus tag
Dmel_CG1578
See related
AllianceGenome:FB:FBgn0030336
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG1578
Summary
Predicted to enable diphthine-ammonia ligase activity. Predicted to be involved in peptidyl-diphthamide biosynthetic process from peptidyl-histidine. Orthologous to human DPH6 (diphthamine biosynthesis 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
10E5-10E6; 1-36 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11808506..11816551, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11702539..11710584, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Casein kinase II beta subunit Neighboring gene Heat shock protein 70 cognate 3 Neighboring gene rudhira Neighboring gene antisense RNA:CR43908 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Targeting of Painting of fourth to roX1 and roX2 proximal sites suggests evolutionary links between dosage compensation and the regulation of the fourth chromosome in Drosophila melanogaster. Lundberg LE, et al. G3 (Bethesda), 2013 Aug 7. PMID 23733888, Free PMC Article
  2. An expanded toolkit for gene tagging based on MiMIC and scarless CRISPR tagging in Drosophila. Li-Kroeger D, et al. Elife, 2018 Aug 9. PMID 30091705, Free PMC Article
  3. Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor. Miozzo F, et al. Nat Commun, 2022 Mar 17. PMID 35301315, Free PMC Article
  4. Accelerated sequence divergence of conserved genomic elements in Drosophila melanogaster. Holloway AK, et al. Genome Res, 2008 Oct. PMID 18583644, Free PMC Article
  5. X-chromosome-wide profiling of MSL-1 distribution and dosage compensation in Drosophila. Legube G, et al. Genes Dev, 2006 Apr 1. PMID 16547175, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables diphthine-ammonia ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables diphthine-ammonia ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein histidyl modification to diphthamide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein histidyl modification to diphthamide ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG1578-PA
CG1578-PB
CG1578-PC
NP_001285140.1
NP_001285141.1
NP_572749.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11808506..11816551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298212.1 → NP_001285141.1  uncharacterized protein Dmel_CG1578, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285141.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MRI4, Q9VYU1
    Conserved Domains (3) summary
    cd06155
    Location:465 → 561
    eu_AANH_C_1; A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the first of these ...
    cd06156
    Location:610 → 716
    eu_AANH_C_2; A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the second of these ...
    cd01994
    Location:2 → 211
    Alpha_ANH_like_IV; This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily ...

  2. NM_132521.3 → NP_572749.2  uncharacterized protein Dmel_CG1578, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572749.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MRI4, Q9VYU1
    Conserved Domains (3) summary
    cd06155
    Location:465 → 561
    eu_AANH_C_1; A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the first of these ...
    cd06156
    Location:610 → 716
    eu_AANH_C_2; A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the second of these ...
    cd01994
    Location:2 → 211
    Alpha_ANH_like_IV; This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily ...

  3. NM_001298211.1 → NP_001285140.1  uncharacterized protein Dmel_CG1578, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285140.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MRI4, Q9VYU1
    Conserved Domains (3) summary
    cd06155
    Location:465 → 561
    eu_AANH_C_1; A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the first of these ...
    cd06156
    Location:610 → 716
    eu_AANH_C_2; A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the second of these ...
    cd01994
    Location:2 → 211
    Alpha_ANH_like_IV; This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MRI4 Q8MRI4

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