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HOXA11 homeobox A11 [ Homo sapiens (human) ]

Gene ID: 3207, updated on 8-May-2016
Official Symbol
HOXA11provided by HGNC
Official Full Name
homeobox A11provided by HGNC
Primary source
HGNC:HGNC:5101
See related
Ensembl:ENSG00000005073 HPRD:00846; MIM:142958; Vega:OTTHUMG00000023437
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOX1; HOX1I; RUSAT1
Summary
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq, Jul 2008]
Orthologs
Location:
7p15.2
Exon count:
2
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (27181157..27185216, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (27220776..27224835, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene HOXA10-HOXA9 readthrough Neighboring gene HOXA10 antisense RNA Neighboring gene microRNA 196b Neighboring gene homeobox A10 Neighboring gene HOXA11 antisense RNA Neighboring gene homeobox A13

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
branching involved in ureteric bud morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
cartilage development involved in endochondral bone morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
developmental growth ISS
Inferred from Sequence or Structural Similarity
more info
 
dorsal/ventral pattern formation ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic digit morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic forelimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic limb morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic skeletal joint morphogenesis IEA
Inferred from Electronic Annotation
more info
 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
mesodermal cell fate specification ISS
Inferred from Sequence or Structural Similarity
more info
 
metanephros development IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development ISS
Inferred from Sequence or Structural Similarity
more info
 
organ induction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of chondrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
proximal/distal pattern formation IEA
Inferred from Electronic Annotation
more info
 
single fertilization IEA
Inferred from Electronic Annotation
more info
 
skeletal system development ISS
Inferred from Sequence or Structural Similarity
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
uterus development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 
protein complex ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-DNA complex ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
homeobox protein Hox-A11
Names
homeo box 1I
homeobox protein HOXA11
homeobox protein Hox-1I

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012079.1 RefSeqGene

    Range
    5001..9060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_561

mRNA and Protein(s)

  1. NM_005523.5NP_005514.1  homeobox protein Hox-A11

    See identical proteins and their annotated locations for NP_005514.1

    Status: REVIEWED

    Source sequence(s)
    AC004080, BC040948
    Consensus CDS
    CCDS5411.1
    UniProtKB/Swiss-Prot
    P31270
    Related
    ENSP00000006015, OTTHUMP00000217288, ENST00000006015, OTTHUMT00000358754
    Conserved Domains (2) summary
    pfam12045
    Location:25168
    DUF3528; Protein of unknown function (DUF3528)
    cd00086
    Location:242298
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

    Range
    27181157..27185216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    27220497..27224560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)