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HOXA9 homeobox A9 [ Homo sapiens (human) ]

Gene ID: 3205, updated on 8-May-2016
Official Symbol
HOXA9provided by HGNC
Official Full Name
homeobox A9provided by HGNC
Primary source
HGNC:HGNC:5109
See related
Ensembl:ENSG00000078399 HPRD:00844; MIM:142956; Vega:OTTHUMG00000023220
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOX1; ABD-B; HOX1G; HOX1.7
Summary
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011]
Orthologs
Location:
7p15.2
Exon count:
2
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (27162438..27165530, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (27202057..27205149, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene homeobox A3 Neighboring gene HOXA cluster antisense RNA 3 Neighboring gene homeobox A6 Neighboring gene homeobox A7 Neighboring gene HOXA10-HOXA9 readthrough Neighboring gene HOXA10 antisense RNA Neighboring gene microRNA 196b Neighboring gene homeobox A10

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Readthrough HOXA10-HOXA9

Readthrough gene: HOXA10-HOXA9, Included gene: HOXA10

Homology

Clone Names

  • MGC1934

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
definitive hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
embryonic forelimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic skeletal system development IEA
Inferred from Electronic Annotation
more info
 
endothelial cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
mammary gland development IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
negative regulation of myeloid cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
proximal/distal pattern formation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
single fertilization IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
uterus development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
homeobox protein Hox-A9
Names
homeobox protein Hox-1G
homeodomain protein HOXA9

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029923.1 RefSeqGene

    Range
    5001..8093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_152739.3NP_689952.1  homeobox protein Hox-A9

    See identical proteins and their annotated locations for NP_689952.1

    Status: REVIEWED

    Source sequence(s)
    AW612618, BC006537, BG258601, CA442923
    Consensus CDS
    CCDS5409.1
    UniProtKB/Swiss-Prot
    P31269
    Related
    ENSP00000343619, OTTHUMP00000217260, ENST00000343483, OTTHUMT00000358706
    Conserved Domains (2) summary
    cd00086
    Location:207263
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04617
    Location:1193
    Hox9_act; Hox9 activation region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

    Range
    27162438..27165530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    27201773..27204865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)