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Lefty2 left-right determination factor 2 [ Mus musculus (house mouse) ]

Gene ID: 320202, updated on 24-Jun-2016
Official Symbol
Lefty2provided by MGI
Official Full Name
left-right determination factor 2provided by MGI
Primary source
MGI:MGI:2443573
See related
Ensembl:ENSMUSG00000066652 Vega:OTTMUSG00000021474
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ebaf; Lefta; Leftb; lefty-2; lefty-B; 6030463A22Rik
Orthologs
Location:
1; 1 H4
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (180893108..180899107)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (182823250..182829234)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L32 pseudogene Neighboring gene predicted gene, 39714 Neighboring gene pyrroline-5-carboxylate reductase family, member 2 Neighboring gene predicted gene, 32199

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Clone Names

  • MGC98569

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
cell development IBA
Inferred from Biological aspect of Ancestor
more info
 
cell growth IEA
Inferred from Electronic Annotation
more info
 
growth IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
left-right determination factor 2
Names
endometrial bleeding associated factor
left-right determination factor B
left-right determination, factor A

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177099.4NP_796073.1  left-right determination factor 2 precursor

    See identical proteins and their annotated locations for NP_796073.1

    Status: VALIDATED

    Source sequence(s)
    AK031621, BE994648
    Consensus CDS
    CCDS15575.1
    UniProtKB/Swiss-Prot
    P57785
    Related
    ENSMUSP00000082952, OTTMUSP00000023877, ENSMUST00000085797, OTTMUST00000050909
    Conserved Domains (2) summary
    pfam00688
    Location:40240
    TGFb_propeptide; TGF-beta propeptide
    cl02510
    Location:265355
    TGF_beta; Transforming growth factor beta like domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

    Range
    180893108..180899107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)