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Hist1h2ab histone cluster 1, H2ab [ Mus musculus (house mouse) ]

Gene ID: 319172, updated on 28-May-2016
Official Symbol
Hist1h2abprovided by MGI
Official Full Name
histone cluster 1, H2abprovided by MGI
Primary source
MGI:MGI:2448306
See related
Ensembl:ENSMUSG00000061615 Vega:OTTMUSG00000000580
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H2A.1; H2a-53
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]
Orthologs
Location:
13; 13 A2-A3
Exon count:
1
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 13 NC_000079.6 (23751088..23751592)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (23842957..23843462)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene predicted gene 11336 Neighboring gene histone cluster 1, H2bb Neighboring gene histone cluster 1, H3b Neighboring gene histone cluster 1, H4b

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
chromatin silencing IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
histone H2A type 1
Names
histone 1, H2ab

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175660.3NP_783591.2  histone H2A type 1

    See identical proteins and their annotated locations for NP_783591.2

    Status: REVIEWED

    Source sequence(s)
    AL590388
    Consensus CDS
    CCDS26364.1
    UniProtKB/Swiss-Prot
    P22752
    UniProtKB/TrEMBL
    B2RVF0
    Related
    ENSMUSP00000077477, OTTMUSP00000000550, ENSMUST00000078369, OTTMUST00000001170
    Conserved Domains (2) summary
    PTZ00017
    Location:1130
    PTZ00017; histone H2A; Provisional
    cd00074
    Location:6120
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p3 C57BL/6J

    Range
    23751088..23751592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000035.1 Alternate Mm_Celera

    Range
    23982859..23983363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)