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    HNRNPL heterogeneous nuclear ribonucleoprotein L [ Homo sapiens ]

    Gene ID: 3191, updated on 11-May-2012
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    Summary

    Official Symbol
    HNRNPLprovided by HGNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Lprovided by HGNC
    Primary source
    HGNC:5045
    Locus tag
    P/OKcl.14
    See related
    Ensembl:ENSG00000104824; HPRD:04360; MIM:603083
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HNRPL; hnRNP-L; P/OKcl.14; FLJ35509
    Summary
    Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    19q13.2
    Sequence :
    Chromosome: 19; NC_000019.9 (39327028..39342979, complement)
    See HNRNPL in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100507591 Neighboring gene uncharacterized LOC100289396 Neighboring gene enoyl CoA hydratase 1, peroxisomal Neighboring gene Ras and Rab interactor-like Neighboring gene sirtuin 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). Lopitz-Otsoa F, et al. J Proteomics, 2012 Jun 6. PMID 22178446.
    2. Proteomic dissection of the von Hippel-Lindau (VHL) interactome. Lai Y, et al. J Proteome Res, 2011 Nov 4. PMID 21942715.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    5. Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. Rowbotham SP, et al. Mol Cell, 2011 May 6. PMID 21549307.

    See all (62) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. NSP 5a3a's novel interaction with B23 and ribonuclear protein hnRNP-L implicates NSP 5a3a in cellular processes such as ribosome biogenesis and rRNA transcription .
      Title: NSP 5a3a's link to nuclear-cyto proteins B23 and hnRNP-L between normal and aberrant breast cell lines.
    2. Mechanistic control of carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1) splice isoforms by the heterogeneous nuclear ribonuclear proteins hnRNP L, hnRNP A1, and hnRNP M.
      Title: Mechanistic control of carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1) splice isoforms by the heterogeneous nuclear ribonuclear proteins hnRNP L, hnRNP A1, and hnRNP M.
    3. Hypoxia induces translocation of nuclear hnRNP L to the cytoplasm, which markedly increases hnRNP L binding to VEGFA mRNA thereby inhibiting miRNA activity.
      Title: Repression of VEGFA by CA-rich element-binding microRNAs is modulated by hnRNP L.
    4. hnRNP L represses splicing by preventing 5' splice site recognition of the U1 snRNP.
      Title: HnRNP L-mediated regulation of mammalian alternative splicing by interference with splice site recognition.
    5. The binding of hnRNP L to an exon represses strong splice sites but enhances weak splice sites.
      Title: Context-dependent regulatory mechanism of the splicing factor hnRNP L.
    6. identified hnRNP L as a novel Sam68-interacting protein partner.
      Title: Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 Nuclear Bodies.
    7. confirm the interactions of eEF1A1, p54(nrb), hnRNP-L, GAPDH and ASF/SF2 with the right terminal stem-loop domain of HDV genomic RNA in vitro
      Title: The hepatitis delta virus RNA genome interacts with eEF1A1, p54(nrb), hnRNP-L, GAPDH and ASF/SF2.
    8. Identification of a novel, higher eukaryotic specific subunit, heterogeneous nuclear ribonucleoprotein L (HnRNP-L)required for lysine methylation in vivo.
      Title: Heterogeneous nuclear ribonucleoprotein L Is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo.
    9. CA repeats in the 3'UTR of bcl-2 mRNA interact with hnRNP L in vitro and in vivo; this physical association is partially involved in the decay of bcl-2 mRNA.
      Title: hnRNP L binds to CA repeats in the 3'UTR of bcl-2 mRNA.
    10. hnRNP L cross-regulates inclusion of an analogous poison exon in the hnRNP L-like pre-mRNA, which explains the reciprocal expression of the two closely related hnRNP L proteins.
      Title: Auto- and cross-regulation of the hnRNP L proteins by alternative splicing.
    Submit: New GeneRIF Correction See all (17)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001524.2 GSTZ1    BIND  PubMed hnRNP L interacts with GSTZ1 RNA. 
    NP_001524.2 NP_002131.2 HNRNPK    BIND  PubMed hnRNP L interacts with hnRNP K. This interaction was modeled on a demonstrated interaction between hnRNP K from an unspecified source and human hnRNP L. 
    NP_001524.2 NP_002810.1 PTBP1    BIND  PubMed PTB interacts with hnRNP L. 
    NP_001524.2 SLC2A2    BIND  PubMed hnRNP L interacts with SLC2A2 RNA. 
    P14866 P27695 APEX1    HPRD  PubMed  
    P14866 P55060 CSE1L    HPRD  PubMed  
    P14866 P22607 FGFR3    HPRD  PubMed  
    P14866 Q9P0W2 HMG20B    HPRD  PubMed  
    P14866 P22626 HNRNPA2B1    HPRD  PubMed  
    P14866 P61978 HNRNPK    HPRD  PubMed  
    P14866 P14866 HNRNPL    HPRD  PubMed  
    P14866 Q15366 PCBP2    HPRD  PubMed  
    P14866 Q8NG27 PJA1    HPRD  PubMed  
    P14866 P26599 PTBP1    HPRD  PubMed  
    P14866 Q6EEV6 SUMO4    HPRD  PubMed  
    BioGRID:109432 BioGRID:106825 APEX1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109432 BioGRID:107821 CSE1L    BioGRID  PubMed Two-hybrid 
    BioGRID:109432 BioGRID:115081 DOCK4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109432 BioGRID:108286 EIF2B1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109432 BioGRID:108552 FGFR3    BioGRID  PubMed Two-hybrid 
    BioGRID:109432 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109432 BioGRID:115642 HMG20B    BioGRID  PubMed Two-hybrid 
    BioGRID:109432 BioGRID:109420 HNRNPA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109432 BioGRID:109422 HNRNPA2B1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109432 BioGRID:109431 HNRNPK    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109432 BioGRID:109432 HNRNPL    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109432 BioGRID:123747 ITCH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109432 BioGRID:128436 KHDRBS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109432 BioGRID:248934 Khdrbs3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109432 BioGRID:110811 NEDD4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109432 BioGRID:111127 PCBP2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109432 BioGRID:111697 PTBP1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109432 BioGRID:116502 PUF60    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109432 BioGRID:121244 SMARCAD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109432 BioGRID:117071 SRRM2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109432 BioGRID:113188 SUMO1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109432 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109432 BioGRID:132223 SUMO4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109432 BioGRID:113003 TOP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109432 BioGRID:115505 TOPORS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109432 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Co-purification; Reconstituted Complex 
    BioGRID:109432 BioGRID:113269 VHL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109432 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • mRNA Splicing, organism-specific biosystem (from REACTOME)
      mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
    • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    RNA processing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    RNA splicing TAS
    Traceable Author Statement
    more info
    		  
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    nuclear mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    heterogeneous nuclear ribonucleoprotein complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    pronucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoprotein L
    Names
    heterogeneous nuclear ribonucleoprotein L
    hnRNP L
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005335.1 → NP_001005335.1  heterogeneous nuclear ribonucleoprotein L isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AB044547, AK094966, AV743120, BC069184, BI256815, BM997815, BQ334900, X16135
      Consensus CDS
      CCDS33016.1
      UniProtKB/TrEMBL
      A6NIT8
      UniProtKB/Swiss-Prot
      P14866
      UniProtKB/TrEMBL
      Q6NTA2
      Related
      ENSP00000373401, ENST00000388749
      Conserved Domains (2) summary
      cd00590
      Location:71 – 134
      Blast Score: 126
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
      TIGR01649
      Location:1 – 454
      Blast Score: 1670
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    2. NM_001533.2 → NP_001524.2  heterogeneous nuclear ribonucleoprotein L isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AB044547, AK094966, AV743120, BC069184, BI461733, BM997815, BQ334900, X16135
      Consensus CDS
      CCDS33015.1
      UniProtKB/Swiss-Prot
      P14866
      UniProtKB/TrEMBL
      Q6NTA2
      Related
      ENSP00000221419, ENST00000221419
      Conserved Domains (2) summary
      cd00590
      Location:204 – 267
      Blast Score: 126
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
      TIGR01649
      Location:100 – 587
      Blast Score: 1818
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      39327028..39342979, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      35773794..35789557, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC008982.5 (28278..44229) None
    genomic CH471126.1 EAW56826.1
      EAW56827.1
      EAW56828.1
    mRNA AB044547.1 BAB18649.1
    mRNA AK092828.1 None
    mRNA AK094966.1 None
    mRNA AK097975.1 None
    mRNA AK292115.1 BAF84804.1
    mRNA AK298384.1 BAG60620.1
    mRNA AK301062.1 BAG62670.1
    mRNA AK313652.1 BAG36406.1
    mRNA AV743120.2 None
    mRNA AY927544.1 None
    mRNA BC069184.1 AAH69184.2
    mRNA BI256815.1 None
    mRNA BI461733.1 None
    mRNA BM997815.1 None
    mRNA BQ334900.1 None
    mRNA X16135.1 CAA34261.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14866.2 GenPept UniProtKB/Swiss-Prot:P14866
    Q6NTA2 GenPept UniProtKB/TrEMBL:Q6NTA2
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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