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sphinx1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 318005, updated on 4-Apr-2024

Summary

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Official Symbol
sphinx1provided by FlyBase
Primary source
FLYBASE:FBgn0052383
Locus tag
Dmel_CG32383
See related
AllianceGenome:FB:FBgn0052383
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG32383; CG8555; Dmel\CG32383; SPH194; SPH194a; sphinx-1; Sphinx-1; Sphinx1; Spx1
Summary
Involved in defense response to other organism; multicellular organism reproduction; and positive regulation of Toll signaling pathway. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
66A1-66A1; 3-21 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7438421..7439405, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7431521..7432505, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rac2 Neighboring gene uncharacterized protein Neighboring gene sphinx2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolutionary rate patterns of genes involved in the Drosophila Toll and Imd signaling pathway. Han M, et al. BMC Evol Biol, 2013 Nov 8. PMID 24209511, Free PMC Article
  2. Drosophila immunity: a large-scale in vivo RNAi screen identifies five serine proteases required for Toll activation. Kambris Z, et al. Curr Biol, 2006 Apr 18. PMID 16631589
  3. The Drosophila Toll signaling pathway. Valanne S, et al. J Immunol, 2011 Jan 15. PMID 21209287
  4. Identification and function of proteolysis regulators in seminal fluid. Laflamme BA, et al. Mol Reprod Dev, 2013 Feb. PMID 23109270, Free PMC Article
  5. Temporally variable selection on proteolysis-related reproductive tract proteins in Drosophila. Wong A, et al. Mol Biol Evol, 2012 Jan. PMID 21940639, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
  
NOT enables serine-type endopeptidase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in Toll receptor ligand protein activation cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in sexual reproduction IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
sphinx1
Names
CG32383-PB
sphinx1-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    7438421..7439405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168214.2 → NP_729255.2  sphinx1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729255.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V3R6, Q8IQ79
    Conserved Domains (2) summary
    smart00020
    Location:25 → 245
    Tryp_SPc; Trypsin-like serine protease
    cl21584
    Location:26 → 248
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IQ79 Q8IQ79

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