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    org-1 optomotor-blind-related-gene-1 [ Drosophila melanogaster ]

    Gene ID: 31778, updated on 12-May-2012
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    Summary

    Official Symbol
    org-1provided by Flybase
    Official Full Name
    optomotor-blind-related-gene-1provided by Flybase
    Primary source
    FLYBASE:FBgn0021767
    Locus tag
    Dmel_CG11202
    Gene type
    protein coding
    RNA name
    optomotor-blind-related-gene-1
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11202; Dm-ORG-1; Dmel\CG11202; Org-1
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    Genomic context

    Location :
    7E9-7E10
    Sequence :
    Chromosome: X; NC_004354.3 (8342266..8348327, complement)
    See org-1 in Epigenomics, MapViewer

    Chromosome X - NC_004354.3Genomic Context describing neighboring genes Neighboring gene CG1440 gene product from transcript CG1440-RA Neighboring gene CG12123 gene product from transcript CG12123-RA Neighboring gene CG32713 gene product from transcript CG32713-RA Neighboring gene CG15347 gene product from transcript CG15347-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Org-1, the Drosophila ortholog of Tbx1, is a direct activator of known identity genes during muscle specification. Schaub C, et al. Development, 2012 Mar. PMID 22318630.
    2. The transcriptional response of Drosophila melanogaster to infection with the sigma virus (Rhabdoviridae). Carpenter J, et al. PLoS One, 2009 Aug 31. PMID 19718442.
    3. Ancestry-independent fate specification and plasticity in the developmental timing of a typical Drosophila neuronal lineage. Gaziova I, et al. Development, 2009 Jan. PMID 19088087.
    4. Chromosomal rearrangement inferred from comparisons of 12 Drosophila genomes. Bhutkar A, et al. Genetics, 2008 Jul. PMID 18622036.
    5. Selective sweeps in a 2-locus model for sex-ratio meiotic drive in Drosophila simulans. Derome N, et al. Mol Biol Evol, 2008 Feb. PMID 18071199.

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data suggest that org-1 is a common and direct upstream regulator of slou and lb in the developmental pathway of two neighboring muscle lineages.
      Title: Org-1, the Drosophila ortholog of Tbx1, is a direct activator of known identity genes during muscle specification.
    2. Data show that a border between optomotor-blind and brinker expression domains is necessary and sufficient for inducing L5 wing vein development in the posterior regions.
      Title: brinker and optomotor-blind act coordinately to initiate development of the L5 wing vein primordium in Drosophila.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:58237 BioGRID:67866 CG13627    BioGRID  PubMed Two-hybrid 
    BioGRID:58237 BioGRID:66888 CG6904    BioGRID  PubMed Two-hybrid 
    BioGRID:58237 BioGRID:59074 CG8188    BioGRID  PubMed Two-hybrid 
    BioGRID:58237 BioGRID:64190 CG8368    BioGRID  PubMed Two-hybrid 
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    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    CG11202 gene product from transcript CG11202-RA
    Names
    CG11202-PA
    Optomotor-blind-related-1
    omb-related gene-1
    optomotor-blind-related gene-1
    optomotor-blind-related-gene-1
    optomotor-blind-related-protein-1
    org-1-PA
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.3

      Range
      8342266..8348327, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078530.2 → NP_511085.2  optomotor-blind-related-gene-1 [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3F4
      Related
      FBpp0071187, FBtr0071244
      Conserved Domains (1) summary
      cd00182
      Location:195 – 384
      Blast Score: 793
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014298.4 AAF46373.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3F4.1 GenPept
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    Additional Links

    Gene LinkOut

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