HIST2H2AB histone cluster 2, H2ab [Homo sapiens] - Gene

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Summary

Official Symbol: HIST2H2ABprovided by HGNC
Official Full Name: histone cluster 2, H2abprovided by HGNC
Primary source: HGNC:20508
See related: Ensembl:ENSG00000184270; HPRD:13659; Vega:OTTHUMG00000012085
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 1q21

Sequence :: Chromosome: 1; NC_000001.10 (149859019..149859466, complement)

See HIST2H2AB in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Monoubiquitylation of H2A forms part of the cellular response to UV damage and suggest a role of this modification in DNA repair-induced chromatin remodeling.
Title: DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:130469	BioGRID:107056	BARD1	BioGRID	PubMed	Reconstituted Complex
BioGRID:130469	BioGRID:108347	EP300	BioGRID	PubMed	Biochemical Activity
BioGRID:130469	BioGRID:116983	SIRT1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:130469	BioGRID:114045	SMARCA5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:130469	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:130469	BioGRID:122532	WDR77	BioGRID	PubMed	Reconstituted Complex
BioGRID:130469	BioGRID:1205541	tat	BioGRID	PubMed	Protein-peptide

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
nucleosome assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
chromosome	IEA Inferred from Electronic Annotation more info
nucleosome	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: histone H2A type 2-B

Names: histone H2A type 2-B; histone 2, H2ab

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175065.2 → NP_778235.1 histone H2A type 2-B

Status: REVIEWED

Source sequence(s)

AY131972

Consensus CDS

CCDS938.1

UniProtKB/Swiss-Prot

Q8IUE6

Related

ENSP00000332790, OTTHUMP00000013908, ENST00000331128, OTTHUMT00000033440

Conserved Domains (1) summary

cd00074
Location:23 – 120
Blast Score: 427

H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

149859019..149859466, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

121239995..121240442, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL591493.14	CAI12570.1
genomic	AY131972.1	AAN59958.1
genomic	CH471121.2	EAW53603.1
other-genetic	BC172330.1	AAI72330.1