Traf6 TNF-receptor-associated factor 6 [Drosophila melanogaster] - Gene

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Summary

Official Symbol: Traf6provided by Flybase
Official Full Name: TNF-receptor-associated factor 6provided by Flybase
Primary source: FLYBASE:FBgn0026318
Locus tag: Dmel_CG10961
Gene type: protein coding
RNA name: TNF-receptor-associated factor 6
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10961; Dmel\CG10961; dtraf2; dTraf2; dTRAF2; DTRAF2; dTRAF6; TRAF; Traf2; TRAF2; TRAF6

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Genomic context

Location :: 7D16-7D16

Sequence :: Chromosome: X; NC_004354.3 (8048632..8051399, complement)

See Traf6 in Epigenomics, MapViewer

Chromosome X - NC_004354.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

null mutant of DTRAF2 showed immune deficiencies in which NF-kappaB nuclear translocation and antimicrobial gene transcription against microbial infection were severely impaired
Title: Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-kappaB-dependent signaling pathways.

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:58214	BioGRID:72703	CG13245	BioGRID	PubMed	Two-hybrid
BioGRID:58214	BioGRID:68440	CG15529	BioGRID	PubMed	Two-hybrid
BioGRID:58214	BioGRID:63352	CG18128	BioGRID	PubMed	Two-hybrid
BioGRID:58214	BioGRID:66883	CG42788	BioGRID	PubMed	Two-hybrid
BioGRID:58214	BioGRID:65120	CG4893	BioGRID	PubMed	Two-hybrid
BioGRID:58214	BioGRID:62275	CG6220	BioGRID	PubMed	Two-hybrid
BioGRID:58214	BioGRID:67677	CG6738	BioGRID	PubMed	Two-hybrid
BioGRID:58214	BioGRID:66685	CG7488	BioGRID	PubMed	Two-hybrid
BioGRID:58214	BioGRID:63741	CG7974	BioGRID	PubMed	Two-hybrid
BioGRID:58214	BioGRID:59074	CG8188	BioGRID	PubMed	Affinity Capture-Western
BioGRID:58214	BioGRID:59309	CG9577	BioGRID	PubMed	Two-hybrid
BioGRID:58214	BioGRID:60939	CycE	BioGRID	PubMed	Two-hybrid
BioGRID:58214	BioGRID:65936	ECSIT	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:58214	BioGRID:57914	HLH4C	BioGRID	PubMed	Two-hybrid
BioGRID:58214	BioGRID:63689	Rac1	BioGRID	PubMed	Two-hybrid
BioGRID:58214	BioGRID:65211	Rbp6	BioGRID	PubMed	Two-hybrid
BioGRID:58214	BioGRID:63428	RpL39	BioGRID	PubMed	Two-hybrid
BioGRID:58214	BioGRID:63374	TBPH	BioGRID	PubMed	Two-hybrid
BioGRID:58214	BioGRID:58214	Traf6	BioGRID	PubMed	Two-hybrid
BioGRID:58214	BioGRID:57876	brn	BioGRID	PubMed	Two-hybrid
BioGRID:58214	BioGRID:58165	dec-1	BioGRID	PubMed	Two-hybrid

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General gene information

Homology

Homologs of the Traf6 gene: The Traf6 gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, and mosquito.

Pathways from BioSystems

Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
Activated TLR4 signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Endocytosis, organism-specific biosystem (from KEGG)
Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Endocytosis, conserved biosystem (from KEGG)
Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Interleukin-1 signaling, organism-specific biosystem (from REACTOME)
Interleukin-1 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
MyD88 cascade initiated on plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88 dependent cascade initiated on endosome, organism-specific biosystem (from REACTOME)
MyD88 dependent cascade initiated on endosome, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88-independent cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
MyD88-independent cascade initiated on plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
NFkB and MAP kinases activation mediated by TLR4 signaling repertoire, organism-specific biosystem (from REACTOME)
NFkB and MAP kinases activation mediated by TLR4 signaling repertoire, organism-specific biosystemcomputationally inferred pathway (not manually curated)
NOD1/2 Signaling Pathway, organism-specific biosystem (from REACTOME)
NOD1/2 Signaling Pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem (from REACTOME)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Interleukins, organism-specific biosystem (from REACTOME)
Signaling by Interleukins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystem (from REACTOME)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TRAF6 Mediated Induction of proinflammatory cytokines, organism-specific biosystem (from REACTOME)
TRAF6 Mediated Induction of proinflammatory cytokines, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem (from REACTOME)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TRIF mediated TLR3 signaling, organism-specific biosystem (from REACTOME)
TRIF mediated TLR3 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Receptor Cascades, organism-specific biosystem (from REACTOME)
Toll Receptor Cascades, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed
ubiquitin-protein ligase activity	IEA Inferred from Electronic Annotation more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
Toll signaling pathway	TAS Traceable Author Statement more info	PubMed
cell death	IGI Inferred from Genetic Interaction more info	PubMed
defense response	NAS Non-traceable Author Statement more info
NOT defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
dorsal closure	TAS Traceable Author Statement more info	PubMed
innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
protein ubiquitination	IEA Inferred from Electronic Annotation more info
regulation of I-kappaB kinase/NF-kappaB cascade	IMP Inferred from Mutant Phenotype more info	PubMed
signal transduction	NAS Non-traceable Author Statement more info
stress-activated protein kinase signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
intracellular	TAS Traceable Author Statement more info	PubMed

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General protein information

Preferred Names: CG10961 gene product from transcript CG10961-RA

Names: CG10961-PA; TNF-receptor-associated factor 2; TNF-receptor-associated factor 6; Traf6-PA

NP_511080.2

EC 6.3.2.19

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.3

Range

8048632..8051399, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078525.3 → NP_511080.2 TNF-receptor-associated factor 6 [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q9W3I9

Related

FBpp0071136

Conserved Domains (2) summary

cd00162
Location:103 – 141
Blast Score: 121

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd03776
Location:330 – 473
Blast Score: 522

MATH_TRAF6; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF6 subfamily, TRAF domain, C-terminal MATH subdomain; composed of proteins with similarity to human TRAF6, including the Drosophila protein DTRAF2. TRAF molecules serve as adapter ...