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    NR4A1 nuclear receptor subfamily 4, group A, member 1 [ Homo sapiens ]

    Gene ID: 3164, updated on 19-May-2012
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    Summary

    Official Symbol
    NR4A1provided by HGNC
    Official Full Name
    nuclear receptor subfamily 4, group A, member 1provided by HGNC
    Primary source
    HGNC:7980
    See related
    Ensembl:ENSG00000123358; HPRD:00744; MIM:139139; Vega:OTTHUMG00000150393
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HMR; N10; TR3; NP10; GFRP1; NAK-1; NGFIB; NUR77; MGC9485
    Summary
    This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
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    Genomic context

    Location :
    12q13
    Sequence :
    Chromosome: 12; NC_000012.11 (52416616..52453291)
    See NR4A1 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene activin A receptor, type IB Neighboring gene GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein Neighboring gene chromosome 12 open reading frame 44 Neighboring gene olfactory receptor, family 7, subfamily E, member 47 pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. FHL2 protein is a novel co-repressor of nuclear receptor Nur77. Kurakula K, et al. J Biol Chem, 2011 Dec 30. PMID 22049082.
    2. Inhibition of β-catenin signaling by nongenomic action of orphan nuclear receptor Nur77. Sun Z, et al. Oncogene, 2012 May 24. PMID 21986938.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    5. FSH acts on the proliferation of type A spermatogonia via Nur77 that increases GDNF expression in the Sertoli cells. Ding LJ, et al. FEBS Lett, 2011 Aug 4. PMID 21726557.

    See all (111) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Oral squamous carcinoma cells are sensitive to PCH4 and Nur77 protein translocation from the nucleus to the cytoplasm might be associated with the induction of apoptosis by PCH4.
      Title: Expression of Nur77 induced by an n-butylidenephthalide derivative promotes apoptosis and inhibits cell growth in oral squamous cell carcinoma.
    2. association of FHL2 with Nur77 plays a pivotal role in vascular disease.
      Title: FHL2 protein is a novel co-repressor of nuclear receptor Nur77.
    3. Orphan nuclear receptor TR3 suppresses DNA double-strand breaks repair by blocking Ku80 DNA-end binding activity and promoting DNA-PK-induced p53 activity in hepatoma cells.
      Title: Orphan receptor TR3 enhances p53 transactivation and represses DNA double-strand break repair in hepatoma cells under ionizing radiation.
    4. stimulation of peripheral blood mast cells caused a robust upregulation of NR4A2 and, in particular, NR4A3, while NR4A1 expression was only moderately affected
      Title: Differential regulation of Nr4a subfamily nuclear receptors following mast cell activation.
    5. FSH-induced Nur77 regulates the expression of GDNF in Sertoli cells to stimulate the proliferation of A spermatogonia in vitro.
      Title: FSH acts on the proliferation of type A spermatogonia via Nur77 that increases GDNF expression in the Sertoli cells.
    6. results demonstrate that Nur77 acts to promote the growth and survival of colon cancer cells.
      Title: Regulation of Nur77 expression by β-catenin and its mitogenic effect in colon cancer cells.
    7. Data suggest that NR4A1 acts as an antimigratory factor in breast tumours, and further studies should be conducted to understand the mechanisms involved.
      Title: Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell lines.
    8. These results demonstrate that Nur77 is a novel transcription factor that contributes significantly to the regulation of prolactin gene expression in human endometrial stromal cells.
      Title: The orphan nuclear receptor Nur77 regulates decidual prolactin expression in human endometrial stromal cells.
    9. Loss of NR4A1 is associated with thyroid follicular neoplasia.
      Title: Molecular signatures of thyroid follicular neoplasia.
    10. Protein kinase C-regulated role in TCR-induced thymocyte apoptosis
      Title: Protein kinase C regulates mitochondrial targeting of Nur77 and its family member Nor-1 in thymocytes undergoing apoptosis.
    Submit: New GeneRIF Correction See all (80)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr downregulates expression of the gene coding for growth factor-inducible nuclear protein N10 in PHA-stimulated PBMC PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P22736 P31749 AKT1    HPRD  PubMed  
    P22736 Rho guanine nucleotide exchange factor (GEF) 10-like ARHGEF10L    HPRD  PubMed  
    P22736 P54253 ATXN1    HPRD  PubMed  
    P22736 P10415 BCL2    HPRD  PubMed  
    P22736 Q09472 EP300    HPRD  PubMed  
    P22736 Q14802 FXYD3    HPRD  PubMed  
    P22736 Q8TAE8 GADD45GIP1    HPRD  PubMed  
    P22736 Q92831 KAT2B    HPRD  PubMed  
    P22736 P28482 MAPK1    HPRD  PubMed  
    P22736 Q15648 MED1    HPRD  PubMed  
    P22736 Q15788 NCOA1    HPRD  PubMed  
    P22736 Q15596 NCOA2    HPRD  PubMed  
    P22736 Q9Y6Q9 NCOA3    HPRD  PubMed  
    P22736 Q9Y618 NCOR2    HPRD  PubMed  
    P22736 P22736 NR4A1    HPRD  PubMed  
    P22736 P29590 PML    HPRD  PubMed  
    P22736 Q15418 RPS6KA1    HPRD  PubMed  
    P22736 P51812 RPS6KA3    HPRD  PubMed  
    P22736 O75582 RPS6KA5    HPRD  PubMed  
    P22736 Q9UK32 RPS6KA6    HPRD  PubMed  
    P22736 P48443 RXRG    HPRD  PubMed  
    P22736 P04637 TP53    HPRD  PubMed  
    P22736 P63104 YWHAZ    HPRD  PubMed  
    BioGRID:109407 BioGRID:106710 AKT1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:109407 BioGRID:122851 BBS10    BioGRID  PubMed Two-hybrid 
    BioGRID:109407 BioGRID:107068 BCL2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109407 BioGRID:107532 CHD3    BioGRID  PubMed Two-hybrid 
    BioGRID:109407 BioGRID:107533 CHD4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109407 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109407 BioGRID:108237 EEF1A1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109407 BioGRID:108347 EP300    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:109407 BioGRID:116298 FAF1    BioGRID  PubMed Two-hybrid 
    BioGRID:109407 BioGRID:111364 FXYD3    BioGRID  PubMed Two-hybrid 
    BioGRID:109407 BioGRID:124721 GADD45GIP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109407 BioGRID:119237 GLOD4    BioGRID  PubMed Two-hybrid 
    BioGRID:109407 BioGRID:115330 HDAC6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109407 BioGRID:109514 HES1    BioGRID  PubMed Two-hybrid 
    BioGRID:109407 BioGRID:109338 HIF1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109407 BioGRID:109422 HNRNPA2B1    BioGRID  PubMed Two-hybrid 
    BioGRID:109407 BioGRID:109558 HSP90AB1    BioGRID  PubMed Two-hybrid 
    BioGRID:109407 BioGRID:114375 KAT2B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109407 BioGRID:111585 MAPK8    BioGRID  PubMed Biochemical Activity 
    BioGRID:109407 BioGRID:119211 MED31    BioGRID  PubMed Two-hybrid 
    BioGRID:109407 BioGRID:114652 MTA2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109407 BioGRID:115770 MYBBP1A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109407 BioGRID:116763 NACAD    BioGRID  PubMed Two-hybrid 
    BioGRID:109407 BioGRID:114200 NCOA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109407 BioGRID:113841 NCOA3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109407 BioGRID:114974 NCOR2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109407 BioGRID:109165 NR3C1    BioGRID  PubMed Two-hybrid 
    BioGRID:109407 BioGRID:117973 PELP1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109407 BioGRID:111384 PML    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109407 BioGRID:117176 POLA2    BioGRID  PubMed Two-hybrid 
    BioGRID:109407 BioGRID:111469 PPBP    BioGRID  PubMed Two-hybrid 
    BioGRID:109407 BioGRID:115800 PRDX4    BioGRID  PubMed Two-hybrid 
    BioGRID:109407 BioGRID:112019 ROBO2    BioGRID  PubMed Two-hybrid 
    BioGRID:109407 BioGRID:112049 RPL7    BioGRID  PubMed Two-hybrid 
    BioGRID:109407 BioGRID:118144 RPS6KA6    BioGRID  PubMed Two-hybrid 
    BioGRID:109407 BioGRID:121400 RTN4    BioGRID  PubMed Two-hybrid 
    BioGRID:109407 BioGRID:112168 RXRA    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109407 BioGRID:112170 RXRG    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109407 BioGRID:111285 SERPINA4    BioGRID  PubMed Two-hybrid 
    BioGRID:109407 BioGRID:112483 SMARCC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109407 BioGRID:112489 SMARCE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109407 BioGRID:112592 SRC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109407 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109407 BioGRID:112787 TCF4    BioGRID  PubMed Two-hybrid 
    BioGRID:109407 BioGRID:118899 TMOD3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109407 BioGRID:113006 TOP2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109407 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109407 BioGRID:115457 TRIM28    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109407 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109407 BioGRID:113269 VHL    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109407 BioGRID:120663 ZNF331    BioGRID  PubMed Two-hybrid 
    BioGRID:109407 BioGRID:127842 ZNF579    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • AKT phosphorylates targets in the nucleus, organism-specific biosystem (from REACTOME)
      AKT phosphorylates targets in the nucleus, organism-specific biosystemAfter translocation into the nucleus, AKT can phosphorylate a number of targets there such as CREB, forkhead transcription factors, SRK and NUR77.
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystemSecond messengers (calcium, diacylglycerol, inositol 1,4,5-trisphosphate, and phosphatidyinositol 3,4,5-trisphosphate) trigger signaling pathways: NF-kappaB is activated via protein kinase C beta, RA...
    • Downstream signal transduction, organism-specific biosystem (from REACTOME)
      Downstream signal transduction, organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of aro...
    • Downstream signaling of activated FGFR, organism-specific biosystem (from REACTOME)
      Downstream signaling of activated FGFR, organism-specific biosystemSignaling via FGFRs is mediated via direct recruitment of signaling proteins that bind to tyrosine auto-phosphorylation sites on the activated receptor and via closely linked docking proteins that be...
    • GAB1 signalosome, organism-specific biosystem (from REACTOME)
      GAB1 signalosome, organism-specific biosystemGAB1 is recruited to the activated EGFR indirectly, through GRB2. GAB1 acts as an adaptor protein that enables formation of an active PIK3, through recruitment of PIK3 regulatory subunit PIK3R1 (also...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • Glucocorticoid receptor regulatory network, organism-specific biosystem (from Pathway Interaction Database)
      Glucocorticoid receptor regulatory network, organism-specific biosystem
      Glucocorticoid receptor regulatory network
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
      NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
    • Nuclear Receptor transcription pathway, organism-specific biosystem (from REACTOME)
      Nuclear Receptor transcription pathway, organism-specific biosystemA classic example of bifunctional transcription factors is the family of Nuclear Receptor (NR) proteins. These are DNA-binding transcription factors that bind certain hormones, vitamins, and other s...
    • Nuclear Receptors, organism-specific biosystem (from WikiPathways)
      Nuclear Receptors, organism-specific biosystemNuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, th...
    • PI-3K cascade, organism-specific biosystem (from REACTOME)
      PI-3K cascade, organism-specific biosystemThe ability of growth factors to protect from apoptosis is primarily due to the activation of the AKT survival pathway. P-I-3-kinase dependent activation of PDK leads to the activation of AKT which i...
    • PI3K events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
      PI3K events in ERBB2 signaling, organism-specific biosystemERBB2:ERBB3 and ERBB2:ERBB4cyt1 heterodimers activate PI3K signaling by direct binding of PI3K regulatory subunit p85 (Yang et al. 2007, Cohen et al. 1996, Kaushansky et al. 2008) to phosphorylated t...
    • PI3K events in ERBB4 signaling, organism-specific biosystem (from REACTOME)
      PI3K events in ERBB4 signaling, organism-specific biosystemThe CYT1 isoforms of ERBB4 possess a C-tail tyrosine residue that, upon trans-autophosphorylation, serves as a docking site for the p85 alpha subunit of PI3K - PIK3R1 (Kaushansky et al. 2008, Cohen e...
    • PI3K/AKT activation, organism-specific biosystem (from REACTOME)
      PI3K/AKT activation, organism-specific biosystemPI3K/AKT signalling is a major regulator of neuron survival. It blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell...
    • PIP3 activates AKT signaling, organism-specific biosystem (from REACTOME)
      PIP3 activates AKT signaling, organism-specific biosystemSignaling by AKT is one of the key outcomes of activation of receptor tyrosine kinases (RTKs). Following ligand binding and autophosphorylation, RTKs recruit the 85 kDa regulatory subunit of PI3K (PI...
    • RXR and RAR heterodimerization with other nuclear receptor, organism-specific biosystem (from Pathway Interaction Database)
      RXR and RAR heterodimerization with other nuclear receptor, organism-specific biosystem
      RXR and RAR heterodimerization with other nuclear receptor
    • Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
      Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem
      Role of Calcineurin-dependent NFAT signaling in lymphocytes
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by EGFR in Cancer, organism-specific biosystemThe pathway "Signaling by EGFR in Cancer" shows "Signaling by constitutively active EGFR" in parallel with "Signaling by EGFR". This allows users to compare signaling by constitutively active EGFR ca...
    • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
      Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
    • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
    • Signaling by FGFR, organism-specific biosystem (from REACTOME)
      Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
      Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
    • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    steroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cell migration involved in sprouting angiogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cellular response to fibroblast growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cellular response to vascular endothelial growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    endothelial cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    fibroblast growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    induction of apoptosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular receptor mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    nerve growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    phosphatidylinositol-mediated signaling TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    nuclear receptor subfamily 4 group A member 1
    Names
    nuclear receptor subfamily 4 group A member 1
    ST-59
    hormone receptor
    TR3 orphan receptor
    steroid receptor TR3
    testicular receptor 3
    early response protein NAK1
    orphan nuclear receptor HMR
    orphan nuclear receptor TR3
    nuclear hormone receptor NUR/77
    growth factor-inducible nuclear protein N10
    nerve growth factor IB nuclear receptor variant 1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001202233.1 → NP_001189162.1  nuclear receptor subfamily 4 group A member 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and contains an alternate exon in the 5' coding region compared to variant 1. These differences cause translation initiation at an upstream AUG and result in a protein (isoform 2) with a longer N-terminus compared to isoform 1.
      Source sequence(s)
      AC025259, AK297526, BG057763
      Consensus CDS
      CCDS55828.1
      UniProtKB/Swiss-Prot
      P22736
      Related
      ENSP00000353427, ENST00000360284
      Conserved Domains (2) summary
      cd07348
      Location:374 – 611
      Blast Score: 1262
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:278 – 352
      Blast Score: 356
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

    2. NM_002135.4 → NP_002126.2  nuclear receptor subfamily 4 group A member 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AC025259, BC016147, BG057763
      Consensus CDS
      CCDS8818.1
      UniProtKB/Swiss-Prot
      P22736
      UniProtKB/TrEMBL
      Q53Y00
      Related
      ENSP00000243050, ENST00000243050
      Conserved Domains (2) summary
      cd07348
      Location:361 – 598
      Blast Score: 1260
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:265 – 339
      Blast Score: 356
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

    3. NM_173157.2 → NP_775180.1  nuclear receptor subfamily 4 group A member 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), lacks an exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AC025259, BG057763, L13740
      Consensus CDS
      CCDS8818.1
      UniProtKB/Swiss-Prot
      P22736
      UniProtKB/TrEMBL
      Q53Y00
      Related
      ENSP00000378302, ENST00000394825
      Conserved Domains (2) summary
      cd07348
      Location:361 – 598
      Blast Score: 1260
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:265 – 339
      Blast Score: 356
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      52416616..52453291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      49449770..49486519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001202234.1: Suppressed sequence

      Description
      NM_001202234.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NM_173158.1: Suppressed sequence

      Description
      NM_173158.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC025259.49 (24218..40009) None
    genomic CH471111.1 EAW58222.1
      EAW58223.1
      EAW58224.1
      EAW58225.1
      EAW58226.1
      EAW58227.1
      EAW58228.1
    genomic HC025814.1 CBH19838.1
    genomic U17590.1 None
    mRNA AB307717.1 BAH02308.1
    mRNA AK075054.1 None
    mRNA AK075491.1 None
    mRNA AK096816.1 None
    mRNA AK131566.1 BAD18699.1
    mRNA AK297526.1 BAG59929.1
    mRNA AK314437.1 BAG37048.1
    mRNA AL702926.1 None
    mRNA AL831844.1 CAD38550.2
    mRNA BC016147.1 AAH16147.1
    mRNA BG057763.1 None
    mRNA BT007144.1 AAP35808.1
    mRNA CR456704.1 CAG32985.1
    mRNA D49728.1 BAA08565.1
    mRNA D85245.1 BAA12746.1
    mRNA HQ692855.1 ADZ17366.1
    mRNA L13740.1 AAA36763.1
    other-genetic DQ891134.2 ABM82060.1
    other-genetic DQ894313.2 ABM85239.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22736.1 GenPept UniProtKB/Swiss-Prot:P22736
    Q15627 GenPept UniProtKB/TrEMBL:Q15627
    Q53Y00 GenPept UniProtKB/TrEMBL:Q53Y00
    Q6IBU8 GenPept UniProtKB/TrEMBL:Q6IBU8
    Q6ZMM6 GenPept UniProtKB/TrEMBL:Q6ZMM6
    Q8N3V2 GenPept UniProtKB/TrEMBL:Q8N3V2
    Help top of page

    Additional Links

    Gene LinkOut

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