Nck2 NCK adaptor protein 2 [Rattus norvegicus] - Gene

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Summary

Official Symbol: Nck2provided by RGD
Official Full Name: NCK adaptor protein 2provided by RGD
Primary source: RGD:1305965
See related: Ensembl:ENSRNOG00000017155
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus

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Genomic context

Location :: 9q22

Sequence :: Chromosome: 9; NC_005108.2 (42650261..42776967)

See Nck2 in MapViewer

Chromosome 9 - NC_005108.2 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results suggest that Nckbeta maintains paxillin stability during neuritogenesis.
Title: Nckbeta adapter controls neuritogenesis by maintaining the cellular paxillin level.

Submit: New GeneRIF Correction

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Function	Evidence Code	Pubs
kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
actin filament organization	IEA Inferred from Electronic Annotation more info
actin filament organization	ISO Inferred from Sequence Orthology more info
cell migration	IEA Inferred from Electronic Annotation more info
cell migration	ISO Inferred from Sequence Orthology more info
lamellipodium assembly	IEA Inferred from Electronic Annotation more info
lamellipodium assembly	ISO Inferred from Sequence Orthology more info
positive regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
positive regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
vesicle membrane	IEA Inferred from Electronic Annotation more info
vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: cytoplasmic protein NCK2

Names: cytoplasmic protein NCK2; non-catalytic region of tyrosine kinase adaptor protein 2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108216.1 → NP_001101686.1 cytoplasmic protein NCK2

Status: PROVISIONAL

Source sequence(s)

CH473965

UniProtKB/TrEMBL

D4A3M8

Related

ENSRNOP00000023029, ENSRNOT00000023029

Conserved Domains (2) summary

cd00174
Location:199 – 252
Blast Score: 165

SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...

cd10409
Location:283 – 380
Blast Score: 456

SH2_Nck2; Src homology 2 (SH2) domain found in Nck