dx deltex [Drosophila melanogaster] - Gene

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Summary

Official Symbol: dxprovided by Flybase
Official Full Name: deltexprovided by Flybase
Primary source: FLYBASE:FBgn0000524
Locus tag: Dmel_CG3929
Gene type: protein coding
RNA name: deltex
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3929; DMDELTEX; Dmel\CG3929; Dx

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Genomic context

Location :: 6B1-6B2; 1-17.0 cM

Sequence :: Chromosome: X; NC_004354.3 (6428043..6432615)

See dx in Epigenomics, MapViewer

Chromosome X - NC_004354.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

It was shown that Shrub plays a pivotal rate-limiting step in late endosomal ligand-independent Notch activation, depending on the Deltex-dependent ubiquitinylation state of the receptor.
Title: Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal.
Dx-mediated Notch receptor (N) signaling was activated in an endocytic compartment distinct from that in which canonical N signaling is activated, suggesting that N signaling can be activated in 2 different compartments during N's endocytic trafficking.
Title: Roles of Drosophila deltex in Notch receptor endocytic trafficking and activation.
Study shows that Deltex effects require endocytic trafficking by HOPS and AP-3 complexes; Deltex shunts Notch into an endocytic pathway with two possible endpoints.
Title: Drosophila HOPS and AP-3 complex genes are required for a Deltex-regulated activation of notch in the endosomal trafficking pathway.
oligomerization mediated by the RING-H2 finger motif is an integral step in the signaling function of Deltex.(regulation of Notch signaling)
Title: Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling.
the accumulation of Notch (N) in the late-endosome was required for the Dx-mediated Su(H)-independent N signaling
Title: Drosophila deltex mediates suppressor of Hairless-independent and late-endosomal activation of Notch signaling.

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:58076	BioGRID:61074	Arr1	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:66596	CG12256	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:65192	CG13022	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:61207	CG13084	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:59353	CG1314	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:57629	CG14625	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:61109	CG15161	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:59817	CG15423	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:68390	CG15514	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:59447	CG17075	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:59869	CG3225	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:64303	CG32369	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:62530	CG33017	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:57949	CG3323	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:58073	CG3342	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:58133	CG4617	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:59556	CG4896	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:62713	CG5009	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:66919	CG6276	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:64700	CG7264	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:66687	CG7518	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:61727	CG8247	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:64190	CG8368	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:63550	CG9083	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:61309	CG9331	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:60880	CSN1a	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:58538	CkIIbeta	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:59867	Clect27	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:67425	Cpr92F	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:68567	CycG	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:70621	Exp6	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:61931	Git	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:67421	H	BioGRID	PubMed	Phenotypic Suppression
BioGRID:58076	BioGRID:61625	Hey	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:64797	Hip1	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:66904	Hsc70-4	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:58076	BioGRID:58668	IP3K2	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:57823	N	BioGRID	PubMed	Co-localization; Phenotypic Enhancement; Phenotypic Suppression; Two-hybrid
BioGRID:58076	BioGRID:59490	Nle	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:58076	BioGRID:65607	Rab26	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:67360	RhoGAP92B	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:65866	Snr1	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:61430	Src42A	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:71867	Src64B	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:59611	Su(dx)	BioGRID	PubMed	Phenotypic Suppression
BioGRID:58076	BioGRID:68107	Tb	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:63159	ari-2	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:62251	cnn	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:58490	dsh	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:58076	BioGRID:68740	e(r)	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:60919	esg	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:63243	fd59A	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:72394	hrg	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:58076	BioGRID:61489	koi	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:72787	krz	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:62308	mam	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:58076	BioGRID:70018	mts	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:69351	rhi	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:70682	term	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:61114	tos	BioGRID	PubMed	Two-hybrid
BioGRID:58076	BioGRID:77850	zormin	BioGRID	PubMed	Two-hybrid

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General gene information

Homology

Homologs of the dx gene: The dx gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, and zebrafish.

Pathways from BioSystems

Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem (from REACTOME)
Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Notch signaling pathway, organism-specific biosystem (from KEGG)
Notch signaling pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
Notch signaling pathway, conserved biosystem (from KEGG)
Notch signaling pathway, conserved biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by NOTCH, organism-specific biosystem (from REACTOME)
Signaling by NOTCH, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by NOTCH1, organism-specific biosystem (from REACTOME)
Signaling by NOTCH1, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
Notch binding	TAS Traceable Author Statement more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
Notch signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
Notch signaling pathway	TAS Traceable Author Statement more info	PubMed
Wnt receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
positive regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
positive regulation of Notch signaling pathway	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed

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General protein information

Preferred Names: CG3929 gene product from transcript CG3929-RA

Names: CG3929-PA; deltex; dx-PA

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.3

Range

6428043..6432615

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078509.2 → NP_511064.2 deltex [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23985

Related

FBpp0070876, FBtr0070914

Conserved Domains (3) summary

cd00162
Location:548 – 600
Blast Score: 81

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd09633
Location:609 – 735
Blast Score: 565

Deltex_C; Domain found at the C-terminus of deltex-like

cl02729
Location:124 – 201
Blast Score: 232

WWE; WWE domain