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CG12219 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31572, updated on 8-Apr-2024

Summary

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Official Symbol
CG12219provided by FlyBase
Primary source
FLYBASE:FBgn0043796
Locus tag
Dmel_CG12219
See related
AllianceGenome:FB:FBgn0043796
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:LD26135; Dmel\CG12219
Summary
Enables DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human ZNF497 (zinc finger protein 497) and ZNF827 (zinc finger protein 827). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
5E7-5E7; 1-16 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6299054..6301285, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6193087..6195318, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Parallel on-chip gene synthesis and application to optimization of protein expression. Quan J, et al. Nat Biotechnol, 2011 May. PMID 21516083
  2. Global analysis of target genes of 21 members of the ZAD transcription factor family in Drosophila melanogaster. Krystel J, et al. Gene, 2013 Jan 10. PMID 23085320, Free PMC Article
  3. ZAD-Domain Is Essential for Nuclear Localization of Insulator Proteins in Drosophila melanogaster. Zolotarev NA, et al. Acta Naturae, 2016 Jul-Sep. PMID 27795848, Free PMC Article
  4. Innovation of heterochromatin functions drives rapid evolution of essential ZAD-ZNF genes in Drosophila. Kasinathan B, et al. Elife, 2020 Nov 10. PMID 33169670, Free PMC Article
  5. Age-specific variation in immune response in Drosophila melanogaster has a genetic basis. Felix TM, et al. Genetics, 2012 Jul. PMID 22554890, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transcription cis-regulatory region binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG12219-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6299054..6301285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132084.3 → NP_572312.1  uncharacterized protein Dmel_CG12219 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572312.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W409
    Related
    FBpp0070886
    Conserved Domains (4) summary
    COG4049
    Location:149 → 204
    COG4049; Uncharacterized protein, contains archaeal-type C2H2 Zn-finger [General function prediction only]
    sd00017
    Location:140 → 160
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:473 → 493
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam07776
    Location:2 → 94
    zf-AD; Zinc-finger associated domain (zf-AD)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W409 Q9W409

Gene LinkOut

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