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Dmxl2 Dmx-like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315676, updated on 13-Apr-2024

Summary

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Official Symbol
Dmxl2provided by RGD
Official Full Name
Dmx-like 2provided by RGD
Primary source
RGD:1586163
See related
Ensembl:ENSRNOG00000009170 AllianceGenome:RGD:1586163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dmxl2-ps1
Summary
Predicted to enable small GTPase binding activity. Predicted to be involved in vacuolar acidification. Predicted to act upstream of or within several processes, including glucose homeostasis; sensory perception of smell; and spermatogenesis. Is active in synaptic vesicle. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 71 and developmental and epileptic encephalopathy 81. Orthologous to human DMXL2 (Dmx like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 328.3), Kidney (RPKM 204.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q24
Exon count:
45
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (63637314..63803911, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (54741164..54884948, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (58932575..59077788, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL43-like Neighboring gene small nucleolar RNA SNORD113/SNORD114 family Neighboring gene gliomedin Neighboring gene polypyrimidine tract binding protein 1, pseudogene 2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene SH2 domain containing 7 Neighboring gene calcium and integrin binding family member 2 Neighboring gene isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Haploinsufficiency of Dmxl2, encoding a synaptic protein, causes infertility associated with a loss of GnRH neurons in mouse. Tata B, et al. PLoS Biol, 2014 Sep. PMID 25248098, Free PMC Article
  2. Rabconnectin-3, a novel protein that binds both GDP/GTP exchange protein and GTPase-activating protein for Rab3 small G protein family. Nagano F, et al. J Biol Chem, 2002 Mar 22. PMID 11809763
  3. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within brain development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within corpus callosum development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of sensory perception of smell ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sensory perception of smell ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in vacuolar acidification IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RAVE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuronal dense core vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dmX-like protein 2
Names
Dmx-like 2, pseudogene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427384.1 → NP_001414313.1  dmX-like protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    F1M3W5

  2. NM_001427385.1 → NP_001414314.1  dmX-like protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I5ZMW1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    63637314..63803911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265469.1 → XP_063121539.1  dmX-like protein 2 isoform X3

  2. XM_008766360.4 → XP_008764582.1  dmX-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A6J4L2
    Conserved Domains (4) summary
    COG2319
    Location:2769 → 3026
    WD40; WD40 repeat [General function prediction only]
    pfam12234
    Location:1173 → 1903
    Rav1p_C; RAVE protein 1 C terminal
    sd00039
    Location:2808 → 2848
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:2764 → 3016
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_008766358.4 → XP_008764580.1  dmX-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A6J4L2
    Conserved Domains (4) summary
    COG2319
    Location:2790 → 3047
    WD40; WD40 repeat [General function prediction only]
    pfam12234
    Location:1173 → 1903
    Rav1p_C; RAVE protein 1 C terminal
    sd00039
    Location:2829 → 2869
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:2785 → 3037
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein Strain
Heading Accession and Version

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