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    Top3beta Topoisomerase 3beta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31565, updated on 5-May-2013
    Official Symbol
    Top3betaprovided by FlyBase
    Official Full Name
    Topoisomerase 3betaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026015
    Locus tag
    Dmel_CG3458
    Gene type
    protein coding
    RNA name
    topoisomerase 3beta
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3458; Dmel\CG3458; top3; Top3; TOP3; top3beta; top3[beta]; Topo IIIbeta; topo III[beta]
    Location :
    5E5-5E5
    Sequence :
    Chromosome: X; NC_004354.3 (6178504..6182027, complement)
    See Top3beta in Epigenomics, MapViewer

    Chromosome X - NC_004354.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene CG11700 gene product from transcript CG11700-RB Neighboring gene CG15897 gene product from transcript CG15897-RA Neighboring gene Regulatory particle triple-A ATPase 4 Neighboring gene CG15896 gene product from transcript CG15896-RB Neighboring gene CG15891 gene product from transcript CG15891-RA Neighboring gene CG15892 gene product from transcript CG15892-RB

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Rapid functional divergence of a newly evolved polyubiquitin gene in Drosophila and its role in the trade-off between male fecundity and lifespan. Zhan Z, et al. Mol Biol Evol, 2012 May. PMID 22135190.
    2. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    3. Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. Blanco E, et al. BMC Dev Biol, 2010 Sep 2. PMID 20813047.
    4. Insect response to alphavirus infection--establishment of alphavirus persistence in insect cells involves inhibition of viral polyprotein cleavage. Mudiganti U, et al. Virus Res, 2010 Jun. PMID 20214937.
    5. Laser microdissection of sensory organ precursor cells of Drosophila microchaetes. Buffin E, et al. PLoS One, 2010 Feb 19. PMID 20174573.

    See all (21) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. studies suggest that the topo III enzyme behaves as a structure-specific endonuclease in vivo, providing a reversible DNA cleavage activity that is specific for unpaired regions in the DNA
      Title: Preferential cleavage of plasmid-based R-loops and D-loops by Drosophila topoisomerase IIIbeta.
    Submit: New GeneRIF Correction
    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:58054 BioGRID:64938 CG13472    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:58054 BioGRID:66008 CG15177    BioGRID  PubMed Two-hybrid 
    • Fanconi anemia pathway, organism-specific biosystem (from KEGG)
      Fanconi anemia pathway, organism-specific biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
    • Fanconi anemia pathway, conserved biosystem (from KEGG)
      Fanconi anemia pathway, conserved biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
    • Homologous recombination, organism-specific biosystem (from KEGG)
      Homologous recombination, organism-specific biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
    • Homologous recombination, conserved biosystem (from KEGG)
      Homologous recombination, conserved biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    DNA topoisomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    DNA topoisomerase activity NAS
    Non-traceable Author Statement
    more info
    		  
    DNA topoisomerase type I activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    DNA topoisomerase type I activity NAS
    Non-traceable Author Statement
    more info
    		  
    endodeoxyribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    DNA catabolic process, endonucleolytic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    DNA topological change IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    CG3458 gene product from transcript CG3458-RA
    Names
    CG3458-PA
    Top3beta-PA
    topoisomerase 3
    topoisomerase 3beta
    NP_511059.2

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.3

      Range
      6178504..6182027, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078504.3 → NP_511059.2  topoisomerase 3beta [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96651
      Related
      FBpp0070891, FBtr0070930
      Conserved Domains (3) summary
      cd00186
      Location:171 – 588
      Blast Score: 1009
      TOP1Ac; DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...
      cd03362
      Location:4 – 166
      Blast Score: 437
      TOPRIM_TopoIA_TopoIII; TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving ...
      PRK07219
      Location:4 – 781
      Blast Score: 1121
      PRK07219; DNA topoisomerase I; Validated
    Nucleotide Protein
    Heading Accession and Version
    mRNA BT016116.1 AAV37001.1
    genomic AE014298.4 AAF46144.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U0X6.1 GenPept

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).

      Links to other resources

      General information

      Related sites

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