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Fli1 Fli-1 proto-oncogene, ETS transcription factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 315532, updated on 3-Apr-2024

Summary

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Symbol
Fli1provided by RGD
Full Name
Fli-1 proto-oncogene, ETS transcription factorprovided by RGD
Primary source
RGD:1309837
See related
Ensembl:ENSRNOG00000008904 AllianceGenome:RGD:1309837
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including blood circulation; megakaryocyte development; and regulation of transcription, DNA-templated. Predicted to be located in cytosol and nuclear body. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in blood platelet disease and thrombocytopenia. Orthologous to human FLI1 (Fli-1 proto-oncogene, ETS transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 176.7), Thymus (RPKM 161.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fli1 in Genome Data Viewer
Location:
8q21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (39089526..39209511, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (30831422..30950468, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (33541932..33661111, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 5 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 1 Neighboring gene uncharacterized LOC134479972 Neighboring gene ETS proto-oncogene 1, transcription factor Neighboring gene uncharacterized LOC102552230

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Macrothrombocytopenia and dense granule deficiency associated with FLI1 variants: ultrastructural and pathogenic features. Saultier P, et al. Haematologica, 2017 Jun. PMID 28255014, Free PMC Article
  2. Paris-Trousseau thrombocytopenia is phenocopied by the autosomal recessive inheritance of a DNA-binding domain mutation in FLI1. Stevenson WS, et al. Blood, 2015 Oct 22. PMID 26316623
  3. FLI1 monoallelic expression combined with its hemizygous loss underlies Paris-Trousseau/Jacobsen thrombopenia. Raslova H, et al. J Clin Invest, 2004 Jul. PMID 15232614, Free PMC Article
  4. Ets factors and a newly identified polymorphism regulate Fli1 promoter activity in lymphocytes. Nowling TK, et al. Mol Immunol, 2008 Jan. PMID 17606295, Free PMC Article
  5. Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types. Wei G, et al. Immunity, 2011 Aug 26. PMID 21867929, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within blood circulation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within megakaryocyte development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
Friend leukemia integration 1 transcription factor
Names
Friend leukemia integration 1 transcription factor-like
Friend leukemia virus integration 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017381.2 → NP_001017381.1  Friend leukemia integration 1 transcription factor

    See identical proteins and their annotated locations for NP_001017381.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I6ASZ2, F7FFL9, Q4Z8P1
    Related
    ENSRNOP00000059605.1, ENSRNOT00000068037.2
    Conserved Domains (2) summary
    cd08541
    Location:114 → 204
    SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
    smart00413
    Location:280 → 363
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    39089526..39209511 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265409.1 → XP_063121479.1  Friend leukemia integration 1 transcription factor isoform X2

  2. XM_063265407.1 → XP_063121477.1  Friend leukemia integration 1 transcription factor isoform X1

    UniProtKB/TrEMBL
    A0A8I6A3J9

  3. XM_063265408.1 → XP_063121478.1  Friend leukemia integration 1 transcription factor isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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