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    rux roughex [ Drosophila melanogaster ]

    Gene ID: 31535, updated on 25-May-2012
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    Summary

    Official Symbol
    ruxprovided by Flybase
    Official Full Name
    roughexprovided by Flybase
    Primary source
    FLYBASE:FBgn0003302
    Locus tag
    Dmel_CG4336
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4336; Dmel\CG4336; Rux
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    Genomic context

    Location :
    5D2-5D2; 1-15.0 cM
    Sequence :
    Chromosome: X; NC_004354.3 (5929786..5931833, complement)
    See rux in Epigenomics, MapViewer

    Chromosome X - NC_004354.3Genomic Context describing neighboring genes Neighboring gene CG4766 gene product from transcript CG4766-RA Neighboring gene CG4746 gene product from transcript CG4746-RA Neighboring gene CG5941 gene product from transcript CG5941-RA Neighboring gene CG5937 gene product from transcript CG5937-RD

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. Temporal and spatial windows delimit activation of the outer ring of wingless in the Drosophila wing. Perea D, et al. Dev Biol, 2009 Apr 15. PMID 19217893.
    3. Recurrent events of positive selection in independent Drosophila lineages at the spermatogenesis gene roughex. Llopart A, et al. Genetics, 2008 Jun. PMID 18505872.
    4. Analysis of the Drosophila melanogaster testes transcriptome reveals coordinate regulation of paralogous genes. Mikhaylova LM, et al. Genetics, 2008 May. PMID 18493055.
    5. A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts. Casso DJ, et al. Genetics, 2008 Mar. PMID 18245841.

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. amino acid replacements have contributed disproportionately to divergence, consistent with adaptive evolution at the Rux protein
      Title: Recurrent events of positive selection in independent Drosophila lineages at the spermatogenesis gene roughex.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_511053.2 NP_476960.1 CycE    BIND  PubMed CycE (CycEI) interacts with Rux. 
    NP_511053.2 CycJ    BIND  PubMed Rux interacts with an unspecified isoform of CycJ (Cdi5). 
    BioGRID:58031 BioGRID:58653 Bap60    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:66670 CG10126    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:58031 BioGRID:67857 CG13625    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:63648 CG13900    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:64811 CG14119    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:57675 CG14798    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:59148 CG15043    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:63098 CG15676    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:63558 CG15861    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:58330 CG16892    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:60276 CG17292    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:72813 CG18745    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:58203 CG2116    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:63269 CG3085    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:59963 CG31646    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:77797 CG33275    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:60146 CG4496    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:60469 CG5390    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:60446 CG5731    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:60545 CG7296    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:62020 CG9027    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:65565 CSN3    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:60354 Cks30A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:58031 BioGRID:66209 Cks85A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:58031 BioGRID:66526 Csk    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:64701 CycA    BioGRID  PubMed Affinity Capture-MS; Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:58031 BioGRID:63230 CycB    BioGRID  PubMed Affinity Capture-MS; Phenotypic Suppression 
    BioGRID:58031 BioGRID:67895 CycB3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:58031 BioGRID:60939 CycE    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression; Two-hybrid 
    BioGRID:58031 BioGRID:66030 Dfd    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:70060 Gel    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:66726 Lip3    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:66301 Ras85D    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:58031 BioGRID:60110 Rca1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:58031 BioGRID:59534 S    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:58031 BioGRID:59661 Slh    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:59535 ast    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:58031 BioGRID:66028 bcd    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:59806 bowl    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:60495 cdc2    BioGRID  PubMed Affinity Capture-MS; Phenotypic Suppression 
    BioGRID:58031 BioGRID:60833 cenG1A    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:57745 crn    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:67943 dan    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:61353 dimm    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:68740 e(r)    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:59468 ebi    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:58031 BioGRID:63622 klar    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:63711 pUf68    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:65883 rev7    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:66236 skap    BioGRID  PubMed Two-hybrid 
    BioGRID:58031 BioGRID:68333 stg    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:58031 BioGRID:60966 twe    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:58031 BioGRID:60116 wee    BioGRID  PubMed Phenotypic Enhancement 
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    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    compound eye development NAS
    Non-traceable Author Statement
    more info
    		  
    eye-antennal disc morphogenesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of exit from mitosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of meiosis NAS
    Non-traceable Author Statement
    more info
    		  
    regulation of meiosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of mitosis NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG4336 gene product from transcript CG4336-RB
    Names
    CG4336-PA
    CG4336-PB
    Rough-ex
    roughex
    rux-PA
    rux-PB
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.3

      Range
      5929786..5931833, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258611.1 → NP_001245540.1  roughex, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam06020
      Location:1 – 335
      Blast Score: 1381
      Roughex; Drosophila roughex protein

    2. NM_078498.3 → NP_511053.2  roughex, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P50445
      Related
      FBpp0070854
      Conserved Domains (1) summary
      pfam06020
      Location:1 – 335
      Blast Score: 1381
      Roughex; Drosophila roughex protein
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014298.4 AFH07254.1
    genomic AE014298.4 AAF46113.1
    mRNA AY119537.1 AAM50191.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50445.2 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content

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