Format

Send to:

Choose Destination

HMGN2 high mobility group nucleosomal binding domain 2 [ Homo sapiens (human) ]

Gene ID: 3151, updated on 8-May-2016
Official Symbol
HMGN2provided by HGNC
Official Full Name
high mobility group nucleosomal binding domain 2provided by HGNC
Primary source
HGNC:HGNC:4986
See related
Ensembl:ENSG00000198830 HPRD:01230; MIM:163910
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HMG17
Summary
The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. [provided by RefSeq, Oct 2014]
Orthologs
Location:
1p36.1
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (26472411..26476642)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26798902..26803133)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene dehydrodolichyl diphosphate synthase subunit Neighboring gene uncharacterized LOC101928324 Neighboring gene ribosomal protein L17 pseudogene 9 Neighboring gene developmental pluripotency associated 2 pseudogene 2 Neighboring gene ribosomal protein S6 kinase A1 Neighboring gene microRNA 1976

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies transcription regulatory and chromatin remodeling factors LEDGF/p75, KAP1, BTF3b, THRAP3, and HMGN2 as IN-binding partners PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC5629, MGC88718

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nucleosomal DNA binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
chromatin IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
non-histone chromosomal protein HMG-17
Names
high mobility group nucleosome-binding domain-containing protein 2
high mobility group protein N2
high-mobility group (nonhistone chromosomal) protein 17
high-mobility group nucleosomal binding domain 2
nonhistone chromosomal protein HMG-17

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005517.3NP_005508.1  non-histone chromosomal protein HMG-17

    See identical proteins and their annotated locations for NP_005508.1

    Status: REVIEWED

    Source sequence(s)
    AL513365, AU100588, BC071707, BC110390, BU074476
    Consensus CDS
    CCDS283.1
    UniProtKB/Swiss-Prot
    P05204
    Related
    ENSP00000355228, OTTHUMP00000003669, ENST00000361427, OTTHUMT00000009901
    Conserved Domains (1) summary
    pfam01101
    Location:290
    HMG14_17; HMG14 and HMG17

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    26472411..26476642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    26911906..26916138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)