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    HMGN1 high mobility group nucleosome binding domain 1 [ Homo sapiens ]

    Gene ID: 3150, updated on 16-May-2012
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    Summary

    Official Symbol
    HMGN1provided by HGNC
    Official Full Name
    high mobility group nucleosome binding domain 1provided by HGNC
    Primary source
    HGNC:4984
    See related
    Ensembl:ENSG00000205581; HPRD:01231; MIM:163920; Vega:OTTHUMG00000066178
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HMG14; FLJ27265; FLJ31471; MGC104230; MGC117425
    Summary
    The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes. [provided by RefSeq, Aug 2011]
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    Genomic context

    Location :
    21q22.2
    Sequence :
    Chromosome: 21; NC_000021.8 (40714241..40721047, complement)
    See HMGN1 in Epigenomics, MapViewer

    Chromosome 21 - NC_000021.8Genomic Context describing neighboring genes Neighboring gene bromodomain and WD repeat domain containing 1 Neighboring gene methyltransferase like 21A pseudogene 1 Neighboring gene uncharacterized LOC100652972 Neighboring gene BRWD1 intronic transcript 2 (non-protein coding) Neighboring gene ring finger protein (C3H2C3 type) 6 pseudogene 1 Neighboring gene tryptophan rich basic protein

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses. Yang D, et al. J Exp Med, 2012 Jan 16. PMID 22184635.
    2. The chromatin-binding protein HMGN1 regulates the expression of methyl CpG-binding protein 2 (MECP2) and affects the behavior of mice. Abuhatzira L, et al. J Biol Chem, 2011 Dec 9. PMID 22009741.
    3. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). Zhao J, et al. J Proteomics, 2011 Dec 21. PMID 21907836.
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    5. Genomic profiling of HMGN1 reveals an association with chromatin at regulatory regions. Cuddapah S, et al. Mol Cell Biol, 2011 Feb. PMID 21173166.

    See all (36) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. extracellular HMGN1 acts as a novel alarmin critical for LPS-induced development of innate and adaptive immune responses.
      Title: High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.
    2. HMGN1 regulates the expression of methyl CpG-binding protein 2 (MECP2) in mouse and human, and affects the behavior of mice
      Title: The chromatin-binding protein HMGN1 regulates the expression of methyl CpG-binding protein 2 (MECP2) and affects the behavior of mice.
    3. HMGN1 is not randomly distributed throughout the genome. Instead, the protein preferentially localizes to DNase I hypersensitive (HS) sites, promoters, functional enhancers, and transcription factor binding sites.
      Title: Genomic profiling of HMGN1 reveals an association with chromatin at regulatory regions.
    4. HMGN1 (HMG14) and HMGN2 (HMG17) potently repress ATP-dependent chromatin remodeling by four different molecular motor proteins.
      Title: HMGN proteins act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility.
    5. These studies demonstrate that the mode of binding of HMGNs to chromatin is cell cycle dependent.
      Title: Cell cycle-dependent binding of HMGN proteins to chromatin.
    6. These findings indicate that HMGN1 regulates the expression of particular genes via specific protein-protein interactions with transcription factors at target gene regulatory regions.
      Title: HMGN1 modulates estrogen-mediated transcriptional activation through interactions with specific DNA-binding transcription factors.
    7. SWI/SNF functions independently of HMGN1
      Title: Effects of HMGN1 on chromatin structure and SWI/SNF-mediated chromatin remodeling.
    8. Five serine residues, i.e., Ser6, Ser7, Ser85, Ser88, and Ser98, in HMGN1 can be phosphorylated by the kinase in vitro, and Ser6, Ser7, and Ser85 were new sites among these five sites.
      Title: Phosphorylation of human high mobility group N1 protein by protein kinase CK2.
    9. Results show that four serine residues, i.e., Ser6, Ser85, Ser88, and Ser98, can be phosphorylated in high mobility group N1 (HMGN1).
      Title: Identification of novel in vivo phosphorylation sites in high mobility group N1 protein from the MCF-7 human breast cancer cells.
    10. HMGN1 optimizes the cellular response to ionizing radiation and to other tumorigenic events; therefore, loss of this protein increases the tumor burden in mice.
      Title: Increased tumorigenicity and sensitivity to ionizing radiation upon loss of chromosomal protein HMGN1.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P05114 Q09472 EP300    HPRD  PubMed  
    P05114 P05114 HMGN1    HPRD  PubMed  
    P05114 P05204 HMGN2    HPRD  PubMed  
    P05114 P14316 IRF2    HPRD  PubMed  
    P05114 P17612 PRKACA    HPRD  PubMed  
    P05114 P17252 PRKCA    HPRD  PubMed  
    P05114 P51812 RPS6KA3    HPRD  PubMed  
    P05114 O75676 RPS6KA4    HPRD  PubMed  
    P05114 O75582 RPS6KA5    HPRD  PubMed  
    P05114 P63104 YWHAZ    HPRD  PubMed  
    BioGRID:109393 BioGRID:113593 BTG2    BioGRID  PubMed Protein-RNA 
    BioGRID:109393 BioGRID:108347 EP300    BioGRID  PubMed Biochemical Activity 
    BioGRID:109393 BioGRID:108386 ERCC6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109393 BioGRID:109318 HDGF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109393 BioGRID:109393 HMGN1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109393 BioGRID:110850 NFE2    BioGRID  PubMed Two-hybrid 
    BioGRID:109393 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109393 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • p38 MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
      p38 MAPK Signaling Pathway, organism-specific biosystemp38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    positive regulation of transcription elongation, DNA-dependent TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    non-histone chromosomal protein HMG-14
    Names
    non-histone chromosomal protein HMG-14
    nonhistone chromosomal protein HMG-14
    high-mobility group nucleosome binding 1
    high-mobility group nucleosome binding domain 1
    high-mobility group (nonhistone chromosomal) protein 14
    high mobility group nucleosome-binding domain-containing protein 1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004965.6 → NP_004956.5  non-histone chromosomal protein HMG-14

      Status: REVIEWED

      Source sequence(s)
      AL582106, BC070154, BE779939
      Consensus CDS
      CCDS33559.1
      UniProtKB/Swiss-Prot
      P05114
      UniProtKB/TrEMBL
      Q6NSG7
      Related
      ENSP00000370125, OTTHUMP00000068966, ENST00000380749, OTTHUMT00000141645

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000021.8 Reference GRCh37.p5 Primary Assembly

      Range
      40714241..40721047, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000153.1 Alternate HuRef

      Range
      26182661..26189471, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF064861.5 (68795..75601) None
    genomic AL163279.2 CAB90453.1
    genomic CH471079.2 EAX09650.1
      EAX09651.1
      EAX09652.1
      EAX09653.1
      EAX09654.1
      EAX09655.1
      EAX09656.1
    genomic M21339.1 AAA52677.1
    mRNA AB209245.1 BAD92482.1
    mRNA AK056033.1 BAB71078.1
    mRNA AK130775.1 None
    mRNA AK315410.1 None
    mRNA AL582106.2 None
    mRNA BC000075.2 AAH00075.1
    mRNA BC023984.1 AAH23984.1
    mRNA BC070153.1 AAH70153.1
    mRNA BC070154.1 AAH70154.1
    mRNA BC071643.1 AAH71643.1
    mRNA BC072672.1 AAH72672.1
    mRNA BC106080.1 AAI06081.1
    mRNA BC107741.1 AAI07742.1
    mRNA BE779939.1 None
    mRNA BT007337.1 AAP36001.1
    mRNA J02621.1 AAA52676.1
    other-genetic DQ891741.2 ABM82667.1
    other-genetic DQ894919.2 ABM85845.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05114.3 GenPept UniProtKB/Swiss-Prot:P05114
    Q3B790 GenPept UniProtKB/TrEMBL:Q3B790
    Q6NSG7 GenPept UniProtKB/TrEMBL:Q6NSG7
    Q96N32 GenPept UniProtKB/TrEMBL:Q96N32
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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