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Atad2 ATPase family, AAA domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314993, updated on 11-Apr-2024

Summary

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Official Symbol
Atad2provided by RGD
Official Full Name
ATPase family, AAA domain containing 2provided by RGD
Primary source
RGD:1304849
See related
Ensembl:ENSRNOG00000025604 AllianceGenome:RGD:1304849
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP hydrolysis activity; chromatin binding activity; and histone binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human ATAD2 (ATPase family AAA domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 206.0), Spleen (RPKM 178.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q33
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (91523626..91566238, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (89634123..89676738, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (97984754..98027379)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene zinc fingers and homeoboxes 1 Neighboring gene ribosomal protein S10, pseudogene 16 Neighboring gene uncharacterized LOC134479909 Neighboring gene U7 small nuclear RNA Neighboring gene small nucleolar RNA SNORA11 Neighboring gene N-terminal glutamine amidase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification. Zou JX, et al. Proc Natl Acad Sci U S A, 2007 Nov 13. PMID 17998543, Free PMC Article
  2. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleosome disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation-coupled chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATPase family AAA domain-containing protein 2
NP_001128351.1
XP_038935135.1
XP_038935137.1
XP_038935138.1
XP_063119629.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134879.1 → NP_001128351.1  ATPase family AAA domain-containing protein 2

    See identical proteins and their annotated locations for NP_001128351.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473950
    UniProtKB/TrEMBL
    A0A8I5ZNS1, A6HRJ6, D3ZJD2
    Related
    ENSRNOP00000079642.1, ENSRNOT00000112469.1
    Conserved Domains (3) summary
    cd05528
    Location:972 → 1082
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    smart00382
    Location:444 → 585
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:449 → 583
    AAA; ATPase family associated with various cellular activities (AAA)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    91523626..91566238 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079207.2 → XP_038935135.1  ATPase family AAA domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    D3ZJD2
    Conserved Domains (3) summary
    cd05528
    Location:919 → 1029
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    COG0464
    Location:377 → 866
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    cd19517
    Location:359 → 528
    RecA-like_Yta7-like; ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains

  2. XM_063263559.1 → XP_063119629.1  ATPase family AAA domain-containing protein 2 isoform X3

  3. XM_039079210.2 → XP_038935138.1  ATPase family AAA domain-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZVR6
    Conserved Domains (3) summary
    cd05528
    Location:547 → 657
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    COG0464
    Location:5 → 494
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    cl38936
    Location:1 → 156
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. XM_039079209.2 → XP_038935137.1  ATPase family AAA domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZVR6
    Related
    ENSRNOP00000081791.1
    Conserved Domains (3) summary
    cd05528
    Location:643 → 753
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    COG0464
    Location:101 → 590
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    cd19517
    Location:83 → 252
    RecA-like_Yta7-like; ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains
Nucleotide Protein Strain
Heading Accession and Version

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