Display Settings:

Format

Send to:

Choose Destination

Stk11 serine/threonine kinase 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314621, updated on 5-Jul-2015
Official Symbol
Stk11provided by RGD
Official Full Name
serine/threonine kinase 11provided by RGD
Primary source
RGD:1308653
See related
Ensembl:ENSRNOG00000014287
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Lkb1
Orthologs
See Stk11 in MapViewer
Location:
7q11
Exon count:
11
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12440751..12457513, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (12610856..12627616, complement)

Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene midnolin Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit Neighboring gene downstream of Stk11 Neighboring gene strawberry notch homolog 2 (Drosophila) Neighboring gene glutathione peroxidase 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding ISO
Inferred from Sequence Orthology
more info
 
LRR domain binding IEA
Inferred from Electronic Annotation
more info
 
LRR domain binding ISO
Inferred from Sequence Orthology
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
p53 binding ISO
Inferred from Sequence Orthology
more info
 
p53 binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Golgi localization IEA
Inferred from Electronic Annotation
more info
 
Golgi localization ISO
Inferred from Sequence Orthology
more info
 
T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
TCR signalosome assembly IEA
Inferred from Electronic Annotation
more info
 
TCR signalosome assembly ISO
Inferred from Sequence Orthology
more info
 
activation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
anoikis IEA
Inferred from Electronic Annotation
more info
 
anoikis ISO
Inferred from Sequence Orthology
more info
 
autophagy IEA
Inferred from Electronic Annotation
more info
 
axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
axonogenesis ISO
Inferred from Sequence Orthology
more info
 
canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to UV-B IEA
Inferred from Electronic Annotation
more info
 
cellular response to UV-B ISO
Inferred from Sequence Orthology
more info
 
dendrite extension IEA
Inferred from Electronic Annotation
more info
 
dendrite extension ISO
Inferred from Sequence Orthology
more info
 
establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
 
establishment of cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
 
glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway by p53 class mediator ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell proliferation involved in prostate gland development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epithelial cell proliferation involved in prostate gland development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive thymic T cell selection IEA
Inferred from Electronic Annotation
more info
 
positive thymic T cell selection ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein heterooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
response to glucagon IEP
Inferred from Expression Pattern
more info
PubMed 
response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
response to ionizing radiation ISS
Inferred from Sequence or Structural Similarity
more info
 
response to lipid IDA
Inferred from Direct Assay
more info
PubMed 
response to peptide hormone IEP
Inferred from Expression Pattern
more info
PubMed 
spermatid development IEA
Inferred from Electronic Annotation
more info
 
spermatid development ISO
Inferred from Sequence Orthology
more info
 
tissue homeostasis IEA
Inferred from Electronic Annotation
more info
 
tissue homeostasis ISO
Inferred from Sequence Orthology
more info
 
vasculature development ISO
Inferred from Sequence Orthology
more info
 
vasculature development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
TCR signalosome IEA
Inferred from Electronic Annotation
more info
 
TCR signalosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
serine/threonine-protein kinase STK11
Names
liver kinase B1 homolog
serine/threonine-protein kinase 11
serine/threonine-protein kinase LKB1
NP_001101539.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108069.1NP_001101539.1  serine/threonine-protein kinase STK11

    See identical proteins and their annotated locations for NP_001101539.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474029
    Related
    ENSRNOP00000057414, ENSRNOT00000060683
    Conserved Domains (2) summary
    smart00220
    Location:49309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14119
    Location:55309
    STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

    Range
    12440751..12457513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008765096.1XP_008763318.1  

    See identical proteins and their annotated locations for XP_008763318.1

    Conserved Domains (2) summary
    smart00220
    Location:49309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14119
    Location:55309
    STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1
  2. XM_006240910.1XP_006240972.1  

    Conserved Domains (2) summary
    smart00220
    Location:49309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14119
    Location:55309
    STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1

Alternate Rn_Celera

Genomic

  1. AC_000075.1 Alternate Rn_Celera

    Range
    7750545..7767310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)