Fos FBJ osteosarcoma oncogene [Rattus norvegicus (Norway rat)] - Gene

Summary

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Official Symbol: Fosprovided by RGD
Official Full Name: FBJ osteosarcoma oncogeneprovided by RGD
Primary source: RGD:2626
See related: Ensembl:ENSRNOG00000008015
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as: c-fos
Summary: an immediate early gene encoding a nuclear protein involved in signal transduction [RGD, Feb 2006]

Genomic context

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Location :: 6q31

Sequence :: Chromosome: 6; NC_005105.3 (116249742..116252608, complement)

See Fos in MapViewer

Chromosome 6 - NC_005105.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Electroacupuncture can relieve chronic visceral hyperalgesia in rats with inflammtory bowel syndrome in part by down-regulating the high expression of NR1 and c-fos.
Title: Effects of electroacupuncture on expression of c-fos protein and N-methyl-D-aspartate receptor 1 in the rostral ventromedial medulla of rats with chronic visceral hyperalgesia.
This study demonistrated that isolation rearing alters C-fos activation in the mPFC produced by exposure to a novel conspecific, in addition to changing social behavior, and that these effects depend in part on sex.
Title: Isolation rearing attenuates social interaction-induced expression of immediate early gene protein products in the medial prefrontal cortex of male and female rats.
c-Fos protein expression is increased for one hour in hippocampus, demonstrating DNA methylation as a regulator of electroconvulsive stimulation (ECS)-induced gene expression.
Title: Epigenetic regulation of Arc and c-Fos in the hippocampus after acute electroconvulsive stimulation in the rat.
Antisense Fos oligodeoxynucleotide infused locally into perirhinal cortex to interfere with Fos production abolished recognition memory. Fos is necessary for this function.
Title: Interfering with Fos expression in rat perirhinal cortex impairs recognition memory.
Immunoreactive neurons are identified by c-Fos expression in cardiorespiratory areas where the no-exercise rats exhibit minimal Fos expression.
Title: Pontomedullary and hypothalamic distribution of Fos-like immunoreactive neurons after acute exercise in rats.
FosB levels in the brain were increased following excessive ethanol consumption, but were reduced after six-day 100 Hz electroacupuncture.
Title: Electroacupuncture decreases excessive alcohol consumption involving reduction of FosB/ΔFosB levels in reward-related brain regions.
TGF strongly up-regulates c-fos gene expression in hepatic stellate cells.
Title: [Regulation of c-fos gene expression in hepatic stellate cells by transforming growth factor beta].
Rats trained and tested with cocaine-seeking, cue-elicited craving are reinstated to a novel, not a familiar, light or tone.
Title: Novel cues reinstate cocaine-seeking behavior and induce Fos protein expression as effectively as conditioned cues.
Nerve injury causes differential effects on c-Fos expression in the subnucleus oralis and caudalis of the trigeminal sensory nuclear complex, which may explain complexity of neuropathic pain symptoms in clinical cases.
Title: Fos protein-like immunoreactive neurons induced by electrical stimulation in the trigeminal sensory nuclear complex of rats with chronically injured peripheral nerve.
The results of this experiment implicate the OPFC and the ventral striatum in the control of timing performance on the free-operant timing schedule.
Title: Fos expression in the prefrontal cortex and ventral striatum after exposure to a free-operant timing schedule.

Submit: New GeneRIF Correction See all (263)

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
TVRTFS	NP_040842.1	tat	BIND	PubMed	The visna virus protein Tat interacts with rat Fos.
U02631.1	NP_110487.1	Mef2d	BIND	PubMed	SRF interacts with c-fos gene promoter.
XP_234422.2	NP_068607.1	Jun	BIND	PubMed	Fos interacts with Jun. This interaction was modelled on a demonstrated interaction between Rattus rattus fos and Rattus norvegicus jun.
BioGRID:260681	BioGRID:219977	Smarcd1	BioGRID	PubMed	Reconstituted Complex

Pathways from BioSystems

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Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
Activated TLR4 signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activation of the AP-1 family of transcription factors, organism-specific biosystem (from REACTOME)
Activation of the AP-1 family of transcription factors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Amphetamine addiction, organism-specific biosystem (from KEGG)
Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
Amphetamine addiction, conserved biosystem (from KEGG)
Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
B cell receptor signaling pathway, organism-specific biosystem (from KEGG)
B cell receptor signaling pathway, organism-specific biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
B cell receptor signaling pathway, conserved biosystem (from KEGG)
B cell receptor signaling pathway, conserved biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
Cholinergic synapse, organism-specific biosystem (from KEGG)
Cholinergic synapse, organism-specific biosystemAcetylcholine (ACh) is a neurotransmitter widely distributed in the central (and also peripheral, autonomic and enteric) nervous system (CNS). In the CNS, ACh facilitates many functions, such as lear...
Circadian entrainment, organism-specific biosystem (from KEGG)
Circadian entrainment, organism-specific biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
Circadian entrainment, conserved biosystem (from KEGG)
Circadian entrainment, conserved biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
Colorectal cancer, organism-specific biosystem (from KEGG)
Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
Colorectal cancer, conserved biosystem (from KEGG)
Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
Dopaminergic synapse, organism-specific biosystem (from KEGG)
Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
Dopaminergic synapse, conserved biosystem (from KEGG)
Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
Estrogen signaling pathway, organism-specific biosystem (from KEGG)
Estrogen signaling pathway, organism-specific biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
Estrogen signaling pathway, conserved biosystem (from KEGG)
Estrogen signaling pathway, conserved biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
Estrogen signalling, organism-specific biosystem (from WikiPathways)
Estrogen signalling, organism-specific biosystemEstrogen receptor refers to a group of receptors which are activated by the hormone 17&amp;#x3b2;-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear h...
HTLV-I infection, organism-specific biosystem (from KEGG)
HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
HTLV-I infection, conserved biosystem (from KEGG)
HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
Hepatitis B, organism-specific biosystem (from KEGG)
Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
Herpes simplex infection, organism-specific biosystem (from KEGG)
Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Herpes simplex infection, conserved biosystem (from KEGG)
Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-6 Signaling Pathway, organism-specific biosystem
IL-6 Signaling Pathway
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Insulin Signaling, organism-specific biosystem (from WikiPathways)
Insulin Signaling, organism-specific biosystem
Insulin Signaling
Leishmaniasis, organism-specific biosystem (from KEGG)
Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
Leishmaniasis, conserved biosystem (from KEGG)
Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
MAP kinase activation in TLR cascade, organism-specific biosystem (from REACTOME)
MAP kinase activation in TLR cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, organism-specific biosystem (from KEGG)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, conserved biosystem (from KEGG)
MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK targets/ Nuclear events mediated by MAP kinases, organism-specific biosystem (from REACTOME)
MAPK targets/ Nuclear events mediated by MAP kinases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
MyD88 cascade initiated on plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88 dependent cascade initiated on endosome, organism-specific biosystem (from REACTOME)
MyD88 dependent cascade initiated on endosome, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88-independent cascade, organism-specific biosystem (from REACTOME)
MyD88-independent cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
Myometrial Relaxation and Contraction Pathways, organism-specific biosystem
Myometrial Relaxation and Contraction Pathways
NFE2L2, organism-specific biosystem (from WikiPathways)
NFE2L2, organism-specific biosystem
NFE2L2
Osteoclast differentiation, organism-specific biosystem (from KEGG)
Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
Osteoclast differentiation, conserved biosystem (from KEGG)
Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
Oxidative Stress, organism-specific biosystem (from WikiPathways)
Oxidative Stress, organism-specific biosystem
Oxidative Stress
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Pertussis, organism-specific biosystem (from KEGG)
Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
Pertussis, conserved biosystem (from KEGG)
Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
Rheumatoid arthritis, organism-specific biosystem (from KEGG)
Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
Rheumatoid arthritis, conserved biosystem (from KEGG)
Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
Salmonella infection, organism-specific biosystem (from KEGG)
Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
Salmonella infection, conserved biosystem (from KEGG)
Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
Selenium metabolism Selenoproteins, organism-specific biosystem (from WikiPathways)
Selenium metabolism Selenoproteins, organism-specific biosystem* Comments belonging to specific genes on the Selenoprotein pathway ** TRXND3 gene: Although the geneID is correct, the sequence of this gene was guessed by analogy. ** Cystathionine gamma-lyase is t...
Serotonin and anxiety, organism-specific biosystem (from WikiPathways)
Serotonin and anxiety, organism-specific biosystem
Serotonin and anxiety
Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem (from WikiPathways)
Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem
Signaling of Hepatocyte Growth Factor Receptor
Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
T Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
T Cell Receptor Signaling Pathway, organism-specific biosystem
T Cell Receptor Signaling Pathway
T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
T cell receptor signaling pathway, conserved biosystem (from KEGG)
T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
TGF-beta Receptor Signaling Pathway, organism-specific biosystem
TGF-beta Receptor Signaling Pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem (from REACTOME)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystem (from REACTOME)
TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
Toll-Like Receptors Cascades, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
Toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
Toll-like receptor signaling pathway, organism-specific biosystem
Toll-like receptor signaling pathway
Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...

General gene information

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Markers

WI-19801 (e-PCR)
- UniSTS:18950

Fos (e-PCR), detects polymorphism
- UniSTS:143124

Fos (e-PCR), detects polymorphism
- UniSTS:143125

PMC99986P2 (e-PCR)
- UniSTS:273714

BP240034A10G4 (e-PCR)
- UniSTS:519219

PMC108124P1 (e-PCR)
- UniSTS:270133

PMC151804P3 (e-PCR)
- UniSTS:271177

Fos (e-PCR), detects polymorphism
- UniSTS:256935

PMC321436P2 (e-PCR)
- UniSTS:273107

Homology

Homologs of the Fos gene: The Fos gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, and zebrafish.
Map Viewer (Human, Mouse)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
DNA binding	IDA Inferred from Direct Assay more info	PubMed
DNA binding	ISO Inferred from Sequence Orthology more info
R-SMAD binding	IEA Inferred from Electronic Annotation more info
R-SMAD binding	ISO Inferred from Sequence Orthology more info
double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IC Inferred by Curator more info	PubMed
protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
sequence-specific DNA binding transcription factor activity	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
transcription factor binding	IPI Inferred from Physical Interaction more info
transcription regulatory region DNA binding	IEA Inferred from Electronic Annotation more info
transcription regulatory region DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info
SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
aging	IEP Inferred from Expression Pattern more info	PubMed
cellular response to calcium ion	IEA Inferred from Electronic Annotation more info
cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
cellular response to extracellular stimulus	IEA Inferred from Electronic Annotation more info
cellular response to extracellular stimulus	ISO Inferred from Sequence Orthology more info
cellular response to hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
cellular response to reactive oxygen species	IEA Inferred from Electronic Annotation more info
cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
conditioned taste aversion	IEP Inferred from Expression Pattern more info	PubMed
female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
nervous system development	IEA Inferred from Electronic Annotation more info
nervous system development	ISO Inferred from Sequence Orthology more info
positive regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
positive regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
positive regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
response to cold	IEP Inferred from Expression Pattern more info	PubMed
response to corticosterone stimulus	IEP Inferred from Expression Pattern more info	PubMed
response to cytokine stimulus	IEP Inferred from Expression Pattern more info	PubMed
response to drug	IEP Inferred from Expression Pattern more info	PubMed
response to drug	ISO Inferred from Sequence Orthology more info
response to gravity	IEP Inferred from Expression Pattern more info	PubMed
response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed
response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
response to progesterone stimulus	IEP Inferred from Expression Pattern more info	PubMed
response to stress	IEP Inferred from Expression Pattern more info	PubMed
response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
skeletal muscle cell differentiation	ISO Inferred from Sequence Orthology more info
sleep	IEP Inferred from Expression Pattern more info	PubMed
transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
membrane	IDA Inferred from Direct Assay more info	PubMed
neuron projection	IDA Inferred from Direct Assay more info	PubMed
NOT nucleolus	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
nucleus	TAS Traceable Author Statement more info	PubMed
transcription factor complex	IEA Inferred from Electronic Annotation more info
transcription factor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proto-oncogene c-Fos

Names: proto-oncogene c-Fos; c-fos oncogene; proto-oncogene cFOS; FBJ murine osteosarcoma viral oncogene homolog; v-fos FBJ murine osteosarcoma viral oncogene homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022197.2 → NP_071533.1 proto-oncogene c-Fos

Status: PROVISIONAL

Source sequence(s)

DQ089699

UniProtKB/Swiss-Prot

P12841

Related

ENSRNOP00000010712, ENSRNOT00000010712

Conserved Domains (1) summary

smart00338
Location:147 – 185
Blast Score: 131

BRLZ; basic region leucin zipper

RefSeqs of Annotated Genomes: Build 5.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_5.0 Primary Assembly

Genomic

NC_005105.3 Reference Rnor_5.0 Primary Assembly

Range

116249742..116252608, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

AC_000074.1 Alternate Rn_Celera

Range

102942464..102945330

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AABR06045297.1 (85739..88605)	None
genomic	AAHX01045615.1 (55727..58593)	None
genomic	AF126534.1	None	Sprague-Dawley
genomic	AF277645.1	AAG47951.1	F344
genomic	AY780201.1	AAV33852.1	W
genomic	AY780202.1	AAV33853.1	W
genomic	AY780203.1	AAV33854.1	W
genomic	AY786174.1	AAV41063.1	W
genomic	AY828998.1	AAW65541.1	W
genomic	AY828999.1	AAW65542.1	W
genomic	CH473982.1	EDL81573.1
		EDL81574.1
		EDL81575.1
genomic	DQ089699.1	AAZ13764.1	Sprague-Dawley
genomic	M34001.1	AAA42348.1
genomic	U02631.1	None	Sprague-Dawley
mRNA	FQ225996.1	None	Sprague-Dawley
mRNA	FQ228884.1	None	Sprague-Dawley
mRNA	X06769.1	CAA29937.1