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Pnpla8 patatin-like phospholipase domain containing 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314075, updated on 13-Apr-2024

Summary

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Official Symbol
Pnpla8provided by RGD
Official Full Name
patatin-like phospholipase domain containing 8provided by RGD
Primary source
RGD:1311444
See related
Ensembl:ENSRNOG00000039091 AllianceGenome:RGD:1311444
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311444
Summary
Predicted to enable calcium-independent phospholipase A2 activity. Predicted to be involved in several processes, including arachidonic acid secretion; glycerophospholipid metabolic process; and unsaturated fatty acid metabolic process. Predicted to be located in mitochondrion and peroxisomal membrane. Predicted to be active in membrane. Orthologous to human PNPLA8 (patatin like phospholipase domain containing 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 458.2), Adrenal (RPKM 448.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (67056783..67118714)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (61329810..61391736)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (64224870..64288465)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103526 Neighboring gene DnaJ heat shock protein family (Hsp40) member B9 Neighboring gene DnaJ heat shock protein family (Hsp40) member B6, pseudogene 4 Neighboring gene neuronal cell adhesion molecule Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2. Murakami M, et al. J Biol Chem, 2005 Apr 8. PMID 15695510
  2. A novel intracellular membrane-bound calcium-independent phospholipase A(2). Tanaka H, et al. Biochem Biophys Res Commun, 2000 Jun 7. PMID 10833412
  3. The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium-independent phospholipase A(2). Mancuso DJ, et al. J Biol Chem, 2000 Apr 7. PMID 10744668
  4. Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma. Mancuso DJ, et al. J Biol Chem, 2007 Mar 23. PMID 17213206
  5. The highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calcium-independent phospholipase A2gamma: identification of a novel enzymatic mediator for the generation of a key branch point intermediate in eicosanoid signaling. Yan W, et al. J Biol Chem, 2005 Jul 22. PMID 15908428

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium-independent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-independent phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium-independent phospholipase A2 activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables lysophospholipase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidyl phospholipase B activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase A1 activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in arachidonic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in arachidonic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in arachidonic acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in arachidonic acid secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in cardiolipin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cardiolipin metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in linoleic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidylcholine catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylethanolamine catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in triglyceride homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in triglyceride homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
calcium-independent phospholipase A2-gamma
Names
iPLA2-gamma
intracellular membrane-associated calcium-independent phospholipase A2 gamma
patatin-like phospholipase domain-containing protein 8
NP_001101490.2
XP_063117971.1
XP_063117972.1
XP_063117973.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108020.2 → NP_001101490.2  calcium-independent phospholipase A2-gamma

    Status: VALIDATED

    Source sequence(s)
    FQ211866, JAXUCZ010000006
    UniProtKB/Swiss-Prot
    D3ZRC4
    UniProtKB/TrEMBL
    A0A1W2Q6C9
    Related
    ENSRNOP00000049214.3, ENSRNOT00000047296.7
    Conserved Domains (1) summary
    cd07211
    Location:429 → 735
    Pat_PNPLA8; Patatin-like phospholipase domain containing protein 8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    67056783..67118714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261902.1 → XP_063117972.1  calcium-independent phospholipase A2-gamma isoform X2

  2. XM_063261903.1 → XP_063117973.1  calcium-independent phospholipase A2-gamma isoform X2

  3. XM_063261901.1 → XP_063117971.1  calcium-independent phospholipase A2-gamma isoform X1

    UniProtKB/Swiss-Prot
    D3ZRC4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZRC4.1 GenPept UniProtKB/Swiss-Prot:D3ZRC4

Gene LinkOut

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