VhaAC39-1 Vacuolar H[+] ATPase subunit AC39-1 [Drosophila melanogaster] - Gene

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Summary

Official Symbol: VhaAC39-1provided by Flybase
Official Full Name: Vacuolar H[+] ATPase subunit AC39-1provided by Flybase
Primary source: FLYBASE:FBgn0028665
Locus tag: Dmel_CG2934
Gene type: protein coding
RNA name: vacuolar H[+] ATPase subunit AC39-1
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:GressD5; CG2934; Dmel\CG2934; V-ATPase; vhaAC39; Vhaac39; VhaAC39; vhaAC39-1

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Genomic context

Location :: 3F4-3F4

Sequence :: Chromosome: X; NC_004354.3 (3774777..3777000)

See VhaAC39-1 in Epigenomics, MapViewer

Chromosome X - NC_004354.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:57861	BioGRID:61887	14-3-3zeta	BioGRID	PubMed	Two-hybrid
BioGRID:57861	BioGRID:68080	Ald	BioGRID	PubMed	Two-hybrid
BioGRID:57861	BioGRID:65056	Arf72A	BioGRID	PubMed	Two-hybrid
BioGRID:57861	BioGRID:58653	Bap60	BioGRID	PubMed	Two-hybrid
BioGRID:57861	BioGRID:67510	C15	BioGRID	PubMed	Two-hybrid
BioGRID:57861	BioGRID:61234	CG10366	BioGRID	PubMed	Two-hybrid
BioGRID:57861	BioGRID:59061	CG12992	BioGRID	PubMed	Two-hybrid
BioGRID:57861	BioGRID:67685	CG13829	BioGRID	PubMed	Affinity Capture-MS
BioGRID:57861	BioGRID:61591	CG1942	BioGRID	PubMed	Affinity Capture-MS
BioGRID:57861	BioGRID:68609	CG2219	BioGRID	PubMed	Two-hybrid
BioGRID:57861	BioGRID:64758	CG4328	BioGRID	PubMed	Two-hybrid
BioGRID:57861	BioGRID:67575	CG7071	BioGRID	PubMed	Affinity Capture-MS
BioGRID:57861	BioGRID:59607	CG7289	BioGRID	PubMed	Affinity Capture-MS
BioGRID:57861	BioGRID:64175	CG8219	BioGRID	PubMed	Two-hybrid
BioGRID:57861	BioGRID:65001	CrebA	BioGRID	PubMed	Two-hybrid
BioGRID:57861	BioGRID:72803	Dip3	BioGRID	PubMed	Two-hybrid
BioGRID:57861	BioGRID:57579	Dredd	BioGRID	PubMed	Two-hybrid
BioGRID:57861	BioGRID:61922	G-oalpha47A	BioGRID	PubMed	Two-hybrid
BioGRID:57861	BioGRID:59683	Hrs	BioGRID	PubMed	Two-hybrid
BioGRID:57861	BioGRID:624883	Not1	BioGRID	PubMed	Two-hybrid
BioGRID:57861	BioGRID:78249	RpL5	BioGRID	PubMed	Two-hybrid
BioGRID:57861	BioGRID:68313	Vha100-1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:57861	BioGRID:67232	Vha100-2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:57861	BioGRID:62464	Vha14-1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:57861	BioGRID:61782	VhaAC45	BioGRID	PubMed	Affinity Capture-MS
BioGRID:57861	BioGRID:66271	VhaM8.9	BioGRID	PubMed	Affinity Capture-MS
BioGRID:57861	BioGRID:65633	VhaM9.7-b	BioGRID	PubMed	Affinity Capture-MS
BioGRID:57861	BioGRID:62027	inv	BioGRID	PubMed	Two-hybrid
BioGRID:57861	BioGRID:61542	so	BioGRID	PubMed	Two-hybrid

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General gene information

Homology

Homologs of the VhaAC39-1 gene: The VhaAC39-1 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, and rice.

Pathways from BioSystems

Insulin receptor recycling, organism-specific biosystem (from REACTOME)
Insulin receptor recycling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Lysosome, organism-specific biosystem (from KEGG)
Lysosome, organism-specific biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
Lysosome, conserved biosystem (from KEGG)
Lysosome, conserved biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
Metabolic pathways, organism-specific biosystem (from KEGG)
Metabolic pathways, organism-specific biosystem
Metabolic pathways
Oxidative phosphorylation, organism-specific biosystem (from KEGG)
Oxidative phosphorylation, organism-specific biosystem
Oxidative phosphorylation
Oxidative phosphorylation, conserved biosystem (from KEGG)
Oxidative phosphorylation, conserved biosystem
Oxidative phosphorylation
Phagosome, organism-specific biosystem (from KEGG)
Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
Phagosome, conserved biosystem (from KEGG)
Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
Signaling by Insulin receptor, organism-specific biosystemcomputationally inferred pathway (not manually curated)
V-type ATPase, eukaryotes, organism-specific biosystem (from KEGG)
V-type ATPase, eukaryotes, organism-specific biosystemStructural complex; Energy metabolism; ATP synthesis
V-type ATPase, eukaryotes, conserved biosystem (from KEGG)
V-type ATPase, eukaryotes, conserved biosystemStructural complex; Energy metabolism; ATP synthesis

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
hydrogen-exporting ATPase activity, phosphorylative mechanism	ISS Inferred from Sequence or Structural Similarity more info
hydrogen-exporting ATPase activity, phosphorylative mechanism	NAS Non-traceable Author Statement more info

Process	Evidence Code	Pubs
ATP hydrolysis coupled proton transport	IEA Inferred from Electronic Annotation more info
proton transport	NAS Non-traceable Author Statement more info
regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
vacuolar acidification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
plasma membrane	IDA Inferred from Direct Assay more info
vacuolar proton-transporting V-type ATPase, V0 domain	ISS Inferred from Sequence or Structural Similarity more info
vacuolar proton-transporting V-type ATPase, V0 domain	NAS Non-traceable Author Statement more info

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General protein information

Preferred Names: CG2934 gene product from transcript CG2934-RA

Names: CG2934-PA; V-ATPase V0 d subunit; VhaAC39; VhaAC39-1-PA; vacuolar ATPsintase subunit 1; vacuolar H[+] ATPase subunit AC39-1; vacuolar H[+]-ATPase C39 subunit

NP_570080.1

EC 3.6.3.6

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.3

Range

3774777..3777000

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_130724.3 → NP_570080.1 vacuolar H[+] ATPase subunit AC39-1 [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9W4P5

Related

FBpp0070584

Conserved Domains (2) summary

cl00660
Location:20 – 332
Blast Score: 133

PRK01198; V-type ATP synthase subunit C; Provisional

pfam01992
Location:14 – 348
Blast Score: 995

vATP-synt_AC39; ATP synthase (C/AC39) subunit