dm diminutive [Drosophila melanogaster] - Gene

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Summary

Official Symbol: dmprovided by Flybase
Official Full Name: diminutiveprovided by Flybase
Primary source: FLYBASE:FBgn0262656
Locus tag: Dmel_CG10798
Gene type: protein coding
RNA name: diminutive
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO03040301.171; bHLHe57; c-myc; c-Myc; c-MYC; CG10798; d-myc; D-Myc; Dm; dm/dMyc; dm/myc; Dmel\CG10798; dmyc; dMyc; dMYC; Dmyc; DMYc; dmyc1; dMyc1; EG:BACN5I9.1; l(1)G0139; l(1)G0354; l(1)G0359; myc; Myc; MYC

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Genomic context

Location :: 3D1-3D2; 1-4.0 cM

Sequence :: Chromosome: X; NC_004354.3 (3267216..3280049)

See dm in Epigenomics, MapViewer

Chromosome X - NC_004354.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TSC1/2 and Myc coordinate the growth and division of Drosophila intestinal stem cells.
Title: Tuberous sclerosis complex and Myc coordinate the growth and division of Drosophila intestinal stem cells.
The interdependent regulation of Yorkie and the proto-oncogene Myc is described.
Title: Growth control: Myc and Yorkie get connected.
Data show that show that diminutive is an X-linked numerator, a regulator Sxl-Pe.
Title: The Drosophila Myc gene, diminutive, is a positive regulator of the Sex-lethal establishment promoter, Sxl-Pe.
viriato acts downstream of dMyc to ensure a coordinated nucleolar response to dMyc-induced growth and, thereby, normal organ development
Title: The Drosophila Nol12 homologue viriato is a dMyc target that regulates nucleolar architecture and is required for dMyc-stimulated cell growth.
down-regulation of dHCF-associated histone acetyltransferase and histone methyltransferase complexes in vivo interferes with the Myc biological activities.
Title: Drosophila Myc interacts with host cell factor (dHCF) to activate transcription and control growth.
The cell-autonomous upregulation of dMyc is required for the supercompetitive behavior of Yki-expressing cells and Hpo pathway mutant cells.
Title: dMyc functions downstream of Yorkie to promote the supercompetitive behavior of hippo pathway mutant cells.
The codependent regulatory relationship functionally coordinates the cellular activities of Yki and Myc and provides a mechanism of growth control that regulates organ size and has broad implications for cancer.
Title: Evidence for a growth-stabilizing regulatory feedback mechanism between Myc and Yorkie, the Drosophila homolog of Yap.
regulation of dmyc requires interaction between the transcriptional repressor Hfp and the DNA helicase subunit of TFIIH, Haywire (Hay)
Title: Hfp inhibits Drosophila myc transcription and cell growth in a TFIIH/Hay-dependent manner.
In conclusion, the present work reveals an unexpected function of dMyc in the systemic control of growth in response to steroid hormone signaling.
Title: The steroid hormone ecdysone controls systemic growth by repressing dMyc function in Drosophila fat cells.
miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing
Title: The miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing.

Submit: New GeneRIF Correction See all (31)

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:57835	BioGRID:65653	CG11248	BioGRID	PubMed	Two-hybrid
BioGRID:57835	BioGRID:63355	CG12491	BioGRID	PubMed	Two-hybrid
BioGRID:57835	BioGRID:58679	CG1681	BioGRID	PubMed	Two-hybrid
BioGRID:57835	BioGRID:77402	CG31523	BioGRID	PubMed	Two-hybrid
BioGRID:57835	BioGRID:625419	CG34382	BioGRID	PubMed	Two-hybrid
BioGRID:57835	BioGRID:59074	CG8188	BioGRID	PubMed	Affinity Capture-Western
BioGRID:57835	BioGRID:68127	Ets97D	BioGRID	PubMed	Two-hybrid
BioGRID:57835	BioGRID:68622	Hcf	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:57835	BioGRID:77555	LpR1	BioGRID	PubMed	Two-hybrid
BioGRID:57835	BioGRID:65371	Max	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:57835	BioGRID:61860	Mef2	BioGRID	PubMed	Phenotypic Suppression
BioGRID:57835	BioGRID:68899	ND23	BioGRID	PubMed	Two-hybrid
BioGRID:57835	BioGRID:64238	Neos	BioGRID	PubMed	Two-hybrid
BioGRID:57835	BioGRID:66644	Octbeta2R	BioGRID	PubMed	Two-hybrid
BioGRID:57835	BioGRID:66171	Poxm	BioGRID	PubMed	Phenotypic Suppression
BioGRID:57835	BioGRID:62469	Poxn	BioGRID	PubMed	Phenotypic Suppression
BioGRID:57835	BioGRID:66301	Ras85D	BioGRID	PubMed	Phenotypic Suppression
BioGRID:57835	BioGRID:68757	Sdic1	BioGRID	PubMed	Two-hybrid
BioGRID:57835	BioGRID:70789	Tor	BioGRID	PubMed	Phenotypic Suppression
BioGRID:57835	BioGRID:67795	Tsc1	BioGRID	PubMed	Phenotypic Suppression
BioGRID:57835	BioGRID:67123	beat-IIa	BioGRID	PubMed	Two-hybrid
BioGRID:57835	BioGRID:60991	dac	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:57835	BioGRID:65467	gig	BioGRID	PubMed	Phenotypic Suppression
BioGRID:57835	BioGRID:68062	gro	BioGRID	PubMed	Reconstituted Complex
BioGRID:57835	BioGRID:63573	gsb	BioGRID	PubMed	Phenotypic Suppression
BioGRID:57835	BioGRID:60680	prd	BioGRID	PubMed	Phenotypic Suppression
BioGRID:57835	BioGRID:66699	sim	BioGRID	PubMed	Phenotypic Suppression
BioGRID:57835	BioGRID:68651	sv	BioGRID	PubMed	Phenotypic Suppression
BioGRID:57835	BioGRID:63596	thoc7	BioGRID	PubMed	Two-hybrid

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General protein information

Preferred Names: CG10798 gene product from transcript CG10798-RA

Names: CG10798-PA; diminutive; dm-PA; lethal (1) G0354; lethal (1) G0359

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.3

Range

3267216..3280049

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_080323.2 → NP_525062.2 diminutive [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9W4S7

Related

FBpp0070501, FBtr0070525

Conserved Domains (1) summary

cd00083
Location:625 – 682
Blast Score: 129

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...