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HLF HLF, PAR bZIP transcription factor [ Homo sapiens (human) ]

Gene ID: 3131, updated on 8-May-2016
Official Symbol
HLFprovided by HGNC
Official Full Name
HLF, PAR bZIP transcription factorprovided by HGNC
Primary source
HGNC:HGNC:4977
See related
Ensembl:ENSG00000108924 HPRD:00797; MIM:142385; Vega:OTTHUMG00000177840
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Orthologs
Location:
17q22
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (55264960..55325065)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (53342321..53402426)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene target of myb1 like 1 membrane trafficking protein Neighboring gene COX11 cytochrome c oxidase copper chaperone Neighboring gene syntaxin binding protein 4 Neighboring gene uncharacterized LOC101927367 Neighboring gene monocyte to macrophage differentiation associated

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
NHGRI GWA Catalog
Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC33822

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
double-stranded DNA binding TAS
Traceable Author Statement
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor activity, sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
hepatic leukemia factor
Names
PAR bZIP transcription factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046944.1 RefSeqGene

    Range
    5001..65106
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002126.4NP_002117.1  hepatic leukemia factor

    See identical proteins and their annotated locations for NP_002117.1

    Status: REVIEWED

    Source sequence(s)
    AA021027, AF035305, BC036093, DA104709, M95585
    Consensus CDS
    CCDS11585.1
    UniProtKB/Swiss-Prot
    Q16534
    Related
    ENSP00000226067, OTTHUMP00000257772, ENST00000226067, OTTHUMT00000439185
    Conserved Domains (1) summary
    cd14695
    Location:224283
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    55264960..55325065
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257269.1XP_005257326.1  

    See identical proteins and their annotated locations for XP_005257326.1

    Conserved Domains (1) summary
    cd14695
    Location:226284
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
  2. XM_011524705.1XP_011523007.1  

    Related
    ENSP00000461455, OTTHUMP00000257777, ENST00000572002, OTTHUMT00000439190
    Conserved Domains (1) summary
    cd14695
    Location:141199
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    53407306..53467430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)