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ANXA13 annexin A13 [ Homo sapiens (human) ]

Gene ID: 312, updated on 8-May-2016
Official Symbol
ANXA13provided by HGNC
Official Full Name
annexin A13provided by HGNC
Primary source
HGNC:HGNC:536
See related
Ensembl:ENSG00000104537 HPRD:03984; MIM:602573; Vega:OTTHUMG00000164987
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ISA; ANX13
Summary
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this gene has not yet been determined; however, it is associated with the plasma membrane of undifferentiated, proliferating endothelial cells and differentiated villus enterocytes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Orthologs
Location:
8q24.13
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (123680794..123737407, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (124693034..124749647, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375738 Neighboring gene kelch like family member 38 Neighboring gene uncharacterized LOC105375739 Neighboring gene family with sequence similarity 91 member A1 Neighboring gene fer-1 like family member 6 Neighboring gene FER1L6 antisense RNA 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
NHGRI GWA Catalog
Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC150460

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
 
NOT phosphatidylcholine binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylglycerol binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylserine binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of Golgi to plasma membrane protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Golgi to plasma membrane protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
exocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
annexin A13
Names
annexin XIII
annexin, intestine-specific
annexin-13
intestine-specific annexin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003954.2NP_001003954.1  annexin A13 isoform b

    See identical proteins and their annotated locations for NP_001003954.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional segment in the coding region, compared to variant 1. The resulting isoform (b) is longer, compared to isoform a.
    Source sequence(s)
    AC011134, AI678696, AJ306450, AK223374
    Consensus CDS
    CCDS34939.1
    UniProtKB/Swiss-Prot
    P27216
    UniProtKB/TrEMBL
    Q53FB5
    Related
    ENSP00000262219, OTTHUMP00000228108, ENST00000262219, OTTHUMT00000381307
    Conserved Domains (1) summary
    pfam00191
    Location:290355
    Annexin; Annexin
  2. NM_004306.3NP_004297.2  annexin A13 isoform a

    See identical proteins and their annotated locations for NP_004297.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript, and encodes the shorter isoform (a).
    Source sequence(s)
    AC011134, AI678696, AJ306450, AK223374
    Consensus CDS
    CCDS47917.1
    UniProtKB/Swiss-Prot
    P27216
    UniProtKB/TrEMBL
    Q53FB5
    Related
    ENSP00000390809, OTTHUMP00000228109, ENST00000419625, OTTHUMT00000381308
    Conserved Domains (1) summary
    pfam00191
    Location:249314
    Annexin; Annexin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

    Range
    123680794..123737407 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    124733266..124789887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)