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    Pgam5 Phosphoglycerate mutase 5 [ Drosophila melanogaster ]

    Gene ID: 31143, updated on 10-May-2012
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    Summary

    Official Symbol
    Pgam5provided by Flybase
    Official Full Name
    Phosphoglycerate mutase 5provided by Flybase
    Primary source
    FLYBASE:FBgn0023517
    Locus tag
    Dmel_CG14816
    Gene type
    protein coding
    RNA name
    phosphoglycerate mutase 5
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14816; Dmel\CG14816; dPGAM5; DPGAM5; EG:63B12.4
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    Genomic context

    Location :
    2B13-2B13
    Sequence :
    Chromosome: X; NC_004354.3 (1766435..1767570, complement)
    See Pgam5 in Epigenomics, MapViewer

    Chromosome X - NC_004354.3Genomic Context describing neighboring genes Neighboring gene Mediator complex subunit 18 Neighboring gene CG14815 gene product from transcript CG14815-RA Neighboring gene CG14803 gene product from transcript CG14803-RA Neighboring gene Vacuolar protein sorting 26 Neighboring gene CG14817 gene product from transcript CG14817-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila. Imai Y, et al. PLoS Genet, 2010 Dec 2. PMID 21151955.
    3. Genetic effects in Drosophila on the potency of diverse general anesthetics: a distinctive pattern of altered sensitivity. Campbell JL, et al. J Neurogenet, 2009. PMID 19863272.
    4. Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1. Takeda K, et al. Proc Natl Acad Sci U S A, 2009 Jul 28. PMID 19590015.
    5. Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Hoskins RA, et al. Science, 2007 Jun 15. PMID 17569867.

    See all (19) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. PGAM5 negatively regulates the PINK1 pathway related to maintenance of the mitochondria.
      Title: The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:57689 BioGRID:67008 Akt1    BioGRID  PubMed Two-hybrid 
    BioGRID:57689 BioGRID:64801 Atg1    BioGRID  PubMed Two-hybrid 
    BioGRID:57689 BioGRID:66107 CG11286    BioGRID  PubMed Two-hybrid 
    BioGRID:57689 BioGRID:63529 CG3894    BioGRID  PubMed Two-hybrid 
    BioGRID:57689 BioGRID:65669 CycH    BioGRID  PubMed Two-hybrid 
    BioGRID:57689 BioGRID:63921 CycJ    BioGRID  PubMed Two-hybrid 
    BioGRID:57689 BioGRID:72482 CycK    BioGRID  PubMed Two-hybrid 
    BioGRID:57689 BioGRID:65057 DNApol-delta    BioGRID  PubMed Two-hybrid 
    BioGRID:57689 BioGRID:59275 Mer    BioGRID  PubMed Two-hybrid 
    BioGRID:57689 BioGRID:65629 SAK    BioGRID  PubMed Two-hybrid 
    BioGRID:57689 BioGRID:67396 Sirt2    BioGRID  PubMed Two-hybrid 
    BioGRID:57689 BioGRID:67158 ald    BioGRID  PubMed Two-hybrid 
    BioGRID:57689 BioGRID:60206 cdc14    BioGRID  PubMed Two-hybrid 
    BioGRID:57689 BioGRID:67428 cdc2c    BioGRID  PubMed Two-hybrid 
    BioGRID:57689 BioGRID:68359 dmrt99B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:57689 BioGRID:67231 koko    BioGRID  PubMed Two-hybrid 
    BioGRID:57689 BioGRID:68673 nej    BioGRID  PubMed Two-hybrid 
    BioGRID:57689 BioGRID:64732 ssp    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:57689 BioGRID:68659 toy    BioGRID  PubMed Two-hybrid 
    BioGRID:57689 BioGRID:61139 tup    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the Pgam5 gene: The Pgam5 gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, and P.falciparum.

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    response to anesthetic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
    		  
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    General protein information

    Preferred Names
    CG14816 gene product from transcript CG14816-RA
    Names
    CG14816-PA
    Pgam5-PA
    phosphoglycerate mutase 5
    NP_569951.1
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.3

      Range
      1766435..1767570, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130595.2 → NP_569951.1  phosphoglycerate mutase 5 [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46084
      Related
      FBpp0070350, FBtr0070366
      Conserved Domains (1) summary
      cd07067
      Location:88 – 265
      Blast Score: 294
      HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014298.4 AAF45678.1
    genomic AL021106.1 CAA15939.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46084.1 GenPept
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    Additional Links

    Gene LinkOut

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