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Pacsin3 protein kinase C and casein kinase substrate in neurons 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311187, updated on 3-Apr-2024

Summary

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Official Symbol
Pacsin3provided by RGD
Official Full Name
protein kinase C and casein kinase substrate in neurons 3provided by RGD
Primary source
RGD:1307327
See related
Ensembl:ENSRNOG00000014204 AllianceGenome:RGD:1307327
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SdpIII
Summary
Predicted to enable several functions, including calcium channel inhibitor activity; identical protein binding activity; and phospholipid binding activity. Predicted to be involved in several processes, including negative regulation of calcium ion transport; plasma membrane tubulation; and positive regulation of membrane protein ectodomain proteolysis. Predicted to act upstream of or within negative regulation of endocytosis. Predicted to be located in cytosol. Predicted to be active in endosome and plasma membrane. Orthologous to human PACSIN3 (protein kinase C and casein kinase substrate in neurons 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 626.4), Heart (RPKM 232.1) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q24
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (97683054..97691619)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (77227187..77235820)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (80072425..80081058)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene nuclear receptor subfamily 1, group H, member 3 Neighboring gene acid phosphatase 2, lysosomal Neighboring gene damage specific DNA binding protein 2 Neighboring gene ADP-ribosylation factor GTPase activating protein 2 Neighboring gene centriolar satellite-associated tubulin polyglutamylase complex regulator 1 Neighboring gene uncharacterized LOC120101910

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interleukin-6 affects pacsin3, ephrinA4 expression and cytoskeletal proteins in differentiating primary skeletal myoblasts through transcriptional and post-transcriptional mechanisms. Milewska M, et al. Cell Tissue Res, 2020 Apr. PMID 31820147
  2. Versatile membrane deformation potential of activated pacsin. Goh SL, et al. PLoS One, 2012. PMID 23236520, Free PMC Article
  3. Rigidity of wedge loop in PACSIN 3 protein is a key factor in dictating diameters of tubules. Bai X, et al. J Biol Chem, 2012 Jun 22. PMID 22573331, Free PMC Article
  4. Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3. D'hoedt D, et al. J Biol Chem, 2008 Mar 7. PMID 18174177
  5. PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4. Cuajungco MP, et al. J Biol Chem, 2006 Jul 7. PMID 16627472

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interleukin-6 affects pacsin3, ephrinA4 expression and cytoskeletal proteins in differentiating primary skeletal myoblasts through transcriptional and post-transcriptional mechanisms.
    Title: Interleukin-6 affects pacsin3, ephrinA4 expression and cytoskeletal proteins in differentiating primary skeletal myoblasts through transcriptional and post-transcriptional mechanisms.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding ISO
Inferred from Sequence Orthology
more info
  
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in plasma membrane tubulation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma membrane tubulation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
NOT located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein kinase C and casein kinase substrate in neurons protein 3
Names
protein kinase C and casein kinase II substrate protein 3
syndapin III

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009966.3 → NP_001009966.2  protein kinase C and casein kinase substrate in neurons protein 3

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HNC1, G3V9N7, Q5I2Z0
    Related
    ENSRNOP00000054003.4, ENSRNOT00000057176.5
    Conserved Domains (2) summary
    cd11997
    Location:365 → 420
    SH3_PACSIN3; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 3 (PACSIN3)
    cl12013
    Location:16 → 273
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    97683054..97691619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283658.1 → XP_063139728.1  protein kinase C and casein kinase substrate in neurons protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JXX4

  2. XM_063283659.1 → XP_063139729.1  protein kinase C and casein kinase substrate in neurons protein 3 isoform X2

  3. XM_063283660.1 → XP_063139730.1  protein kinase C and casein kinase substrate in neurons protein 3 isoform X3

    UniProtKB/TrEMBL
    A6HNC1, G3V9N7
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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