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Itga4 integrin subunit alpha 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311144, updated on 26-May-2016
Official Symbol
Itga4provided by RGD
Official Full Name
integrin subunit alpha 4provided by RGD
Primary source
RGD:1593249
See related
Ensembl:ENSRNOG00000004861 Vega:OTTRNOG00000001285
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
mouse homolog is involved in adult hematopoietic cell homeostasis, regeneration, and homing [RGD, Feb 2006]
Orthologs
Location:
3q24
Exon count:
28
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (66192977..66264344)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (72754339..72825872)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691829 Neighboring gene uncharacterized LOC102552685 Neighboring gene ceramide kinase-like Neighboring gene uncharacterized LOC102553021 Neighboring gene neuronal differentiation 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
    Cell surface interactions at the vascular wall, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
    Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Dilated cardiomyopathy, conserved biosystem (from KEGG)
    Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • ECM-receptor interaction, organism-specific biosystem (from KEGG)
    ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
  • ECM-receptor interaction, conserved biosystem (from KEGG)
    ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
    Integrin cell surface interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
    Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
  • Intestinal immune network for IgA production, organism-specific biosystem (from KEGG)
    Intestinal immune network for IgA production, organism-specific biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
  • Intestinal immune network for IgA production, conserved biosystem (from KEGG)
    Intestinal immune network for IgA production, conserved biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
  • Leishmaniasis, organism-specific biosystem (from KEGG)
    Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
  • Leishmaniasis, conserved biosystem (from KEGG)
    Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
  • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
    Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
    Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
    Regulation of actin cytoskeleton, conserved biosystem
    Regulation of actin cytoskeleton

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to C-X3-C chemokine binding ISO
Inferred from Sequence Orthology
more info
 
antigen binding IPI
Inferred from Physical Interaction
more info
PubMed 
cell adhesion molecule binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
fibronectin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
fibronectin binding ISO
Inferred from Sequence Orthology
more info
 
protein antigen binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
T cell migration ISO
Inferred from Sequence Orthology
more info
 
blood vessel remodeling ISO
Inferred from Sequence Orthology
more info
 
cell adhesion ISO
Inferred from Sequence Orthology
more info
 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
cell-matrix adhesion involved in ameboidal cell migration IEA
Inferred from Electronic Annotation
more info
 
cell-matrix adhesion involved in ameboidal cell migration ISO
Inferred from Sequence Orthology
more info
 
cellular response to cytokine stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
chorio-allantoic fusion ISO
Inferred from Sequence Orthology
more info
 
clathrin-mediated extracellular exosome endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
diapedesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
endodermal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
endodermal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
face development ISO
Inferred from Sequence Orthology
more info
 
heart development ISO
Inferred from Sequence Orthology
more info
 
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
heterotypic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
import into cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
leukocyte tethering or rolling IEA
Inferred from Electronic Annotation
more info
 
leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of leukocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of leukocyte tethering or rolling IMP
Inferred from Mutant Phenotype
more info
PubMed 
receptor clustering IEA
Inferred from Electronic Annotation
more info
 
receptor clustering ISO
Inferred from Sequence Orthology
more info
 
substrate adhesion-dependent cell spreading IEA
Inferred from Electronic Annotation
more info
 
substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
focal adhesion IEA
Inferred from Electronic Annotation
more info
 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
integrin alpha4-beta7 complex IEA
Inferred from Electronic Annotation
more info
 
integrin alpha4-beta7 complex ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
integrin alpha-4
Names
integrin, alpha 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107737.1NP_001101207.1  integrin alpha-4

    See identical proteins and their annotated locations for NP_001101207.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473949
    Related
    ENSRNOP00000006880, OTTRNOP00000001146, ENSRNOT00000006880, OTTRNOT00000001966
    Conserved Domains (2) summary
    smart00191
    Location:370422
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:467906
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    66192977..66264344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    63623691..63694098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)