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Zeb2 zinc finger E-box binding homeobox 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311071, updated on 8-May-2016
Official Symbol
Zeb2provided by RGD
Official Full Name
zinc finger E-box binding homeobox 2provided by RGD
Primary source
RGD:1307272
See related
Ensembl:ENSRNOG00000004677
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Zfhx1b
Orthologs
Location:
3q12
Exon count:
13
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (29857417..29985930, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (35058725..35186767, complement)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 15 Neighboring gene glycosyltransferase-like domain containing 1 Neighboring gene uncharacterized LOC103691778 Neighboring gene uncharacterized LOC100912577 Neighboring gene uncharacterized LOC102548299 Neighboring gene zinc finger E-box binding homeobox 2, opposite strand

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
  • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF-beta Receptor Signaling Pathway, organism-specific biosystem
    TGF-beta Receptor Signaling Pathway
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
R-SMAD binding IEA
Inferred from Electronic Annotation
more info
 
R-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding IEA
Inferred from Electronic Annotation
more info
 
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
cell proliferation in forebrain IEA
Inferred from Electronic Annotation
more info
 
cell proliferation in forebrain ISO
Inferred from Sequence Orthology
more info
 
central nervous system development ISO
Inferred from Sequence Orthology
more info
 
collateral sprouting IEA
Inferred from Electronic Annotation
more info
 
collateral sprouting ISO
Inferred from Sequence Orthology
more info
 
corpus callosum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
corpus callosum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
corticospinal tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
corticospinal tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
developmental pigmentation IEA
Inferred from Electronic Annotation
more info
 
developmental pigmentation ISO
Inferred from Sequence Orthology
more info
 
embryonic morphogenesis ISO
Inferred from Sequence Orthology
more info
 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
hippocampus development ISO
Inferred from Sequence Orthology
more info
 
mammillary axonal complex development IEA
Inferred from Electronic Annotation
more info
 
mammillary axonal complex development ISO
Inferred from Sequence Orthology
more info
 
melanocyte migration IEA
Inferred from Electronic Annotation
more info
 
melanocyte migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
neural crest cell migration IEA
Inferred from Electronic Annotation
more info
 
neural crest cell migration ISO
Inferred from Sequence Orthology
more info
 
neural tube closure IEA
Inferred from Electronic Annotation
more info
 
neural tube closure ISO
Inferred from Sequence Orthology
more info
 
positive regulation of JUN kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lens fiber cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of lens fiber cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of melanocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of melanocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of melanosome organization IEA
Inferred from Electronic Annotation
more info
 
regulation of melanosome organization ISO
Inferred from Sequence Orthology
more info
 
somitogenesis IEA
Inferred from Electronic Annotation
more info
 
somitogenesis ISO
Inferred from Sequence Orthology
more info
 
transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
zinc finger E-box-binding homeobox 2
Names
zinc finger homeobox 1b

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033701.1NP_001028873.1  zinc finger E-box-binding homeobox 2

    See identical proteins and their annotated locations for NP_001028873.1

    Status: PROVISIONAL

    Source sequence(s)
    AM084708
    UniProtKB/TrEMBL
    Q3T921
    Related
    ENSRNOP00000006350, ENSRNOT00000006350
    Conserved Domains (5) summary
    COG5048
    Location:10241125
    COG5048; FOG: Zn-finger [General function prediction only]
    cd00086
    Location:653695
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam00096
    Location:282304
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:296319
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:10011021
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    29857417..29985930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234145.2XP_006234207.1  

    See identical proteins and their annotated locations for XP_006234207.1

    UniProtKB/TrEMBL
    E9PTC3
    Conserved Domains (5) summary
    COG5048
    Location:10241125
    COG5048; FOG: Zn-finger [General function prediction only]
    cd00086
    Location:653695
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam00096
    Location:282304
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:296319
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:10011021
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_006234144.2XP_006234206.2  

    Conserved Domains (5) summary
    COG5048
    Location:10971198
    COG5048; FOG: Zn-finger [General function prediction only]
    cd00086
    Location:726768
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam00096
    Location:355377
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:369392
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:10741094
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_008761747.1XP_008759969.1  

    See identical proteins and their annotated locations for XP_008759969.1

    UniProtKB/TrEMBL
    E9PTC3
    Conserved Domains (5) summary
    COG5048
    Location:10241125
    COG5048; FOG: Zn-finger [General function prediction only]
    cd00086
    Location:653695
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam00096
    Location:282304
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:296319
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:10011021
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_006234147.2XP_006234209.1  

    Conserved Domains (5) summary
    COG5048
    Location:9601061
    COG5048; FOG: Zn-finger [General function prediction only]
    cd00086
    Location:589631
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam00096
    Location:218240
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:232255
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:937957
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_008761748.1XP_008759970.1  

    Related
    ENSRNOP00000074730, ENSRNOT00000080382
    Conserved Domains (5) summary
    smart00355
    Location:314336
    ZnF_C2H2; zinc finger
    cd00086
    Location:726768
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam00096
    Location:355377
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:369392
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:316336
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    27525557..27647939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)