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ANXA11 annexin A11 [ Homo sapiens (human) ]

Gene ID: 311, updated on 8-May-2016
Official Symbol
ANXA11provided by HGNC
Official Full Name
annexin A11provided by HGNC
Primary source
HGNC:HGNC:535
See related
Ensembl:ENSG00000122359 HPRD:03983; MIM:602572; Vega:OTTHUMG00000018604
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANX11; CAP50
Summary
This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, Dec 2015]
Orthologs
Location:
10q23
Exon count:
21
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (80152610..80205677, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (81914880..81965433, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L22 pseudogene 18 Neighboring gene placenta specific 9 Neighboring gene long intergenic non-protein coding RNA 857 Neighboring gene ribosomal protein S12 pseudogene 2 Neighboring gene uncharacterized LOC100130698 Neighboring gene eukaryotic translation initiation factor 5A pseudogene 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
NHGRI GWA Catalog
Genome-wide association analysis reveals 12q13.3-q14.1 as new risk locus for sarcoidosis.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MHC class II protein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
S100 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatidylethanolamine binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
phagocytosis IEP
Inferred from Expression Pattern
more info
PubMed 
response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
azurophil granule IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
melanosome IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope NAS
Non-traceable Author Statement
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm NAS
Non-traceable Author Statement
more info
PubMed 
phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
specific granule IDA
Inferred from Direct Assay
more info
PubMed 
spindle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
annexin A11
Names
56 kDa autoantigen
CAP-50
annexin XI
annexin-11
autoantigen, 56-kD
calcyclin-associated annexin 50

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001157.2NP_001148.1  annexin A11 isoform 1

    See identical proteins and their annotated locations for NP_001148.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) represents the shortest transcript. Variants a, b, c, d, and e all encode the same isoform (1).
    Source sequence(s)
    AJ278463
    Consensus CDS
    CCDS7364.1
    UniProtKB/Swiss-Prot
    P50995
    UniProtKB/TrEMBL
    Q5T0G8
    Related
    ENSP00000361305, OTTHUMP00000019955, ENST00000372231, OTTHUMT00000049042
    Conserved Domains (1) summary
    pfam00191
    Location:435500
    Annexin; Annexin
  2. NM_001278407.1NP_001265336.1  annexin A11 isoform 1

    See identical proteins and their annotated locations for NP_001265336.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) differs in the 5' UTR compared to variant a. Variants a, b, c, d, and e all encode the same isoform (1).
    Source sequence(s)
    AJ278463, AK056107, AL356095, DA558997
    Consensus CDS
    CCDS7364.1
    UniProtKB/Swiss-Prot
    P50995
    UniProtKB/TrEMBL
    Q5T0G8
    Conserved Domains (1) summary
    pfam00191
    Location:435500
    Annexin; Annexin
  3. NM_001278408.1NP_001265337.1  annexin A11 isoform 1

    See identical proteins and their annotated locations for NP_001265337.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (e) differs in the 5' UTR compared to variant a. Variants a, b, c, d, and e all encode the same isoform (1).
    Source sequence(s)
    AJ278463, AK126287, AL356095, AL513174, BC007564
    Consensus CDS
    CCDS7364.1
    UniProtKB/Swiss-Prot
    P50995
    UniProtKB/TrEMBL
    Q5T0G8
    Conserved Domains (1) summary
    pfam00191
    Location:435500
    Annexin; Annexin
  4. NM_001278409.1NP_001265338.1  annexin A11 isoform 2

    See identical proteins and their annotated locations for NP_001265338.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (f) contains an alternate exon compared to variant 1. This difference results in a distinct 5' UTR and causes translation initiation at a downstream start codon, compared to variant a. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AJ278463, AK301047, AL356095, AL513174
    Consensus CDS
    CCDS60576.1
    UniProtKB/Swiss-Prot
    P50995
    Related
    ENSP00000265447, ENST00000265447
    Conserved Domains (1) summary
    pfam00191
    Location:402467
    Annexin; Annexin
  5. NM_145868.1NP_665875.1  annexin A11 isoform 1

    See identical proteins and their annotated locations for NP_665875.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) differs in the 5' UTR compared to variant a. Variants a, b, c, d, and e all encode the same isoform (1).
    Source sequence(s)
    AJ278464
    Consensus CDS
    CCDS7364.1
    UniProtKB/Swiss-Prot
    P50995
    UniProtKB/TrEMBL
    Q5T0G8
    Related
    ENSP00000404412, OTTHUMP00000019956, ENST00000422982, OTTHUMT00000049043
    Conserved Domains (1) summary
    pfam00191
    Location:435500
    Annexin; Annexin
  6. NM_145869.1NP_665876.1  annexin A11 isoform 1

    See identical proteins and their annotated locations for NP_665876.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (c) differs in the 5' UTR compared to variant a. Variants a, b, c, d, and e all encode the same isoform (1).
    Source sequence(s)
    AJ278465
    Consensus CDS
    CCDS7364.1
    UniProtKB/Swiss-Prot
    P50995
    UniProtKB/TrEMBL
    Q5T0G8
    Related
    ENSP00000398610, OTTHUMP00000019957, ENST00000438331, OTTHUMT00000049044
    Conserved Domains (1) summary
    pfam00191
    Location:435500
    Annexin; Annexin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    80152610..80205677 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539736.1XP_011538038.1  

    See identical proteins and their annotated locations for XP_011538038.1

    UniProtKB/Swiss-Prot
    P50995
    UniProtKB/TrEMBL
    Q5T0G8
    Conserved Domains (1) summary
    pfam00191
    Location:435500
    Annexin; Annexin
  2. XM_005269741.3XP_005269798.1  

    Conserved Domains (1) summary
    pfam00191
    Location:535600
    Annexin; Annexin
  3. XM_005269742.1XP_005269799.1  

    See identical proteins and their annotated locations for XP_005269799.1

    Conserved Domains (1) summary
    pfam00191
    Location:204269
    Annexin; Annexin
  4. XM_006717813.1XP_006717876.1  

    See identical proteins and their annotated locations for XP_006717876.1

    Conserved Domains (1) summary
    pfam00191
    Location:204269
    Annexin; Annexin
  5. XM_011539735.1XP_011538037.1  

    See identical proteins and their annotated locations for XP_011538037.1

    Conserved Domains (1) summary
    pfam00191
    Location:204269
    Annexin; Annexin
  6. XM_006717814.2XP_006717877.1  

    See identical proteins and their annotated locations for XP_006717877.1

    Conserved Domains (1) summary
    pfam00191
    Location:204269
    Annexin; Annexin

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    82197836..82248391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)