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    png pan gu [ Drosophila melanogaster ]

    Gene ID: 31084, updated on 10-May-2012
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    Summary

    Official Symbol
    pngprovided by Flybase
    Official Full Name
    pan guprovided by Flybase
    Primary source
    FLYBASE:FBgn0000826
    Locus tag
    Dmel_CG11420
    Gene type
    protein coding
    RNA name
    pan gu
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11420; Dmel\CG11420; EG:8D8.5; fs(1)M2; pan-gnu; Png; PNG
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    Genomic context

    Location :
    1F4-1F4
    Sequence :
    Chromosome: X; NC_004354.3 (1250521..1251646, complement)
    See png in Epigenomics, MapViewer

    Chromosome X - NC_004354.3Genomic Context describing neighboring genes Neighboring gene CG12773 gene product from transcript CG12773-RA Neighboring gene CG11417 gene product from transcript CG11417-RA Neighboring gene CG14770 gene product from transcript CG14770-RA Neighboring gene sister-of-Sex-lethal Neighboring gene mir-4961 stem loop

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Transport of germ plasm on astral microtubules directs germ cell development in Drosophila. Lerit DA, et al. Curr Biol, 2011 Mar 22. PMID 21376599.
    2. Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila. Janic A, et al. Science, 2010 Dec 24. PMID 21205669.
    3. Regulation of Cyclin A protein in meiosis and early embryogenesis. Vardy L, et al. Proc Natl Acad Sci U S A, 2009 Feb 10. PMID 19181861.
    4. Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells. Georlette D, et al. Genes Dev, 2007 Nov 15. PMID 17978103.
    5. Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Hoskins RA, et al. Science, 2007 Jun 15. PMID 17569867.

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. These data argue that changes in poly(A) tail length are not a universal mechanism governing embryonic cell cycles, and that PNG-mediated derepression of translation is an important alternative mechanism in Drosophila.
      Title: The Drosophila PNG kinase complex regulates the translation of cyclin B.
    2. In Drosophila, the PAN GU (PNG) triggers translation of SMAUG (SMG), a multifunctional posttranscriptional regulator conserved from yeast to humans.
      Title: SMAUG is a major regulator of maternal mRNA destabilization in Drosophila and its translation is activated by the PAN GU kinase.
    3. component of novel protein kinase complex that specifically regulates S-M cell cycles
      Title: The Drosophila cell cycle kinase PAN GU forms an active complex with PLUTONIUM and GNU to regulate embryonic divisions.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_477492.1 NP_476683.1 plu    BIND  PubMed PNG interacts with PLU. 
    BioGRID:57644 BioGRID:60138 CG11266    BioGRID  PubMed Two-hybrid 
    BioGRID:57644 BioGRID:59148 CG15043    BioGRID  PubMed Two-hybrid 
    BioGRID:57644 BioGRID:63098 CG15676    BioGRID  PubMed Two-hybrid 
    BioGRID:57644 BioGRID:61742 CG34350    BioGRID  PubMed Two-hybrid 
    BioGRID:57644 BioGRID:68010 CG4730    BioGRID  PubMed Two-hybrid 
    BioGRID:57644 BioGRID:64118 CG5568    BioGRID  PubMed Two-hybrid 
    BioGRID:57644 BioGRID:62020 CG9027    BioGRID  PubMed Two-hybrid 
    BioGRID:57644 BioGRID:64701 CycA    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:57644 BioGRID:63230 CycB    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:57644 BioGRID:67895 CycB3    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:57644 BioGRID:60939 CycE    BioGRID  PubMed Phenotypic Enhancement; Two-hybrid 
    BioGRID:57644 BioGRID:72482 CycK    BioGRID  PubMed Two-hybrid 
    BioGRID:57644 BioGRID:66030 Dfd    BioGRID  PubMed Two-hybrid 
    BioGRID:57644 BioGRID:63542 Dll    BioGRID  PubMed Two-hybrid 
    BioGRID:57644 BioGRID:63934 IntS10    BioGRID  PubMed Two-hybrid 
    BioGRID:57644 BioGRID:58483 Kap3    BioGRID  PubMed Two-hybrid 
    BioGRID:57644 BioGRID:66726 Lip3    BioGRID  PubMed Two-hybrid 
    BioGRID:57644 BioGRID:67993 MED28    BioGRID  PubMed Two-hybrid 
    BioGRID:57644 BioGRID:63381 PHDP    BioGRID  PubMed Two-hybrid 
    BioGRID:57644 BioGRID:72126 Pp1-87B    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:57644 BioGRID:65211 Rbp6    BioGRID  PubMed Two-hybrid 
    BioGRID:57644 BioGRID:58951 Traf-like    BioGRID  PubMed Two-hybrid 
    BioGRID:57644 BioGRID:66028 bcd    BioGRID  PubMed Two-hybrid 
    BioGRID:57644 BioGRID:61832 dap    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:57644 BioGRID:57669 dor    BioGRID  PubMed Two-hybrid 
    BioGRID:57644 BioGRID:63427 eIF-5A    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:57644 BioGRID:64940 gnu    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:57644 BioGRID:70018 mts    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:57644 BioGRID:66299 rump    BioGRID  PubMed Two-hybrid 
    BioGRID:57644 BioGRID:68433 spn-A    BioGRID  PubMed Two-hybrid 
    BioGRID:57644 BioGRID:67644 vret    BioGRID  PubMed Two-hybrid 
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    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    egg activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		  
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG11420 gene product from transcript CG11420-RA
    Names
    CG11420-PA
    pan gu
    png-PA
    NP_477492.1
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.3

      Range
      1250521..1251646, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058144.2 → NP_477492.1  pan gu [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O46308
      Related
      FBpp0070225, FBtr0070234
      Conserved Domains (2) summary
      cd00180
      Location:14 – 205
      Blast Score: 519
      PKc; Catalytic domain of Protein Kinases
      smart00220
      Location:11 – 271
      Blast Score: 546
      S_TKc; Serine/Threonine protein kinases, catalytic domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL022018.1 CAA17681.1
    genomic AE014298.4 AAF45611.1
    mRNA AF306498.1 AAG28782.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46308.1 GenPept
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    Additional Links

    Gene LinkOut

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