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Fat4 FAT atypical cadherin 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310341, updated on 13-Apr-2024

Summary

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Symbol
Fat4provided by RGD
Full Name
FAT atypical cadherin 4provided by RGD
Primary source
RGD:1564291
See related
Ensembl:ENSRNOG00000028335 AllianceGenome:RGD:1564291
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564291
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; hippo signaling; and nervous system development. Predicted to act upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and condensed mesenchymal cell proliferation. Predicted to be located in apical part of cell. Human ortholog(s) of this gene implicated in Hennekam syndrome and Van Maldergem syndrome 2. Orthologous to human FAT4 (FAT atypical cadherin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 195.7), Adrenal (RPKM 127.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q25
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (123855289..123984716)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (121927266..122056700)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (125751818..125879398)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100576 Neighboring gene uncharacterized LOC134485731 Neighboring gene eukaryotic translation initiation factor 4A1, pseudogene 6 Neighboring gene phosphoglycerate dehydrogenase, pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development. Cappello S, et al. Nat Genet, 2013 Nov. PMID 24056717
  2. Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex. Ishiuchi T, et al. J Cell Biol, 2009 Jun 15. PMID 19506035, Free PMC Article
  3. Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. Mao Y, et al. Development, 2011 Mar. PMID 21303848, Free PMC Article
  4. Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool. Bagherie-Lachidan M, et al. Development, 2015 Aug 1. PMID 26116661
  5. Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation. Das A, et al. Nat Cell Biol, 2013 Sep. PMID 23974041, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cerebral cortex development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within condensed mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within digestive tract development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
involved_in hippo signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inner ear receptor cell stereocilium organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nephron development ISO
Inferred from Sequence Orthology
more info
  
involved_in neurogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ossification involved in bone maturation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within plasma membrane organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of metanephric nephron tubule epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protocadherin Fat 4
Names
FAT tumor suppressor homolog 4
protocadherin Fat 4-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415042.1 → NP_001401971.1  protocadherin Fat 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    D3ZEH1
    Related
    ENSRNOP00000036219.7, ENSRNOT00000038703.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    123855289..123984716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001191705.1: Suppressed sequence

    Description
    NM_001191705.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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