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spdi split discs [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31004, updated on 4-Apr-2024

Summary

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Official Symbol
spdiprovided by FlyBase
Official Full Name
split discsprovided by FlyBase
Primary source
FLYBASE:FBgn0025633
Locus tag
Dmel_CG13366
See related
AllianceGenome:FB:FBgn0025633
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AAD55419; CG13366; Dmel\CG13366; EG:118B3.2
Summary
Involved in adult somatic muscle development; imaginal disc development; and sarcomere organization. Predicted to be part of filamentous actin. Predicted to be active in microtubule organizing center. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in Opitz GBBB syndrome type II and oblique facial clefting 1. Orthologous to several human genes including SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1 like). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See spdi in Genome Data Viewer
Location:
1B10-1B12; 1-0 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (585081..620195, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (479114..514228, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene arginase Neighboring gene uncharacterized protein Neighboring gene beta amyloid protein precursor-like Neighboring gene mir-4960 stem loop Neighboring gene ventral nervous system defective Neighboring gene long non-coding RNA:CR45474 Neighboring gene pseudo Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deficiency of the cytoskeletal protein SPECC1L leads to oblique facial clefting. Saadi I, et al. Am J Hum Genet, 2011 Jul 15. PMID 21703590, Free PMC Article
  2. Calponin homology domains at a glance. Korenbaum E, et al. J Cell Sci, 2002 Sep 15. PMID 12186940
  3. Parallel genetic and proteomic screens identify Msps as a CLASP-Abl pathway interactor in Drosophila. Lowery LA, et al. Genetics, 2010 Aug. PMID 20498300, Free PMC Article
  4. Hedgehog targets in the Drosophila embryo and the mechanisms that generate tissue-specific outputs of Hedgehog signaling. Biehs B, et al. Development, 2010 Nov. PMID 20978080, Free PMC Article
  5. Identification of genes associated with resilience/vulnerability to sleep deprivation and starvation in Drosophila. Thimgan MS, et al. Sleep, 2015 May 1. PMID 25409104, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adult somatic muscle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in notum morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proboscis morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sarcomere organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wing disc development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of filamentous actin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
split discs
Names
CG13366-PA
CG13366-PB
CG13366-PC
CG13366-PD
CG13366-PE
CG13366-PF
CG13366-PG
SPECC1L ortholog
SPECC1L-ortholog
spdi-PA
spdi-PB
spdi-PC
spdi-PD
spdi-PE
spdi-PF
spdi-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    585081..620195 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297820.1 → NP_001284749.1  split discs, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284749.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U4H0, X2J9Z8
    Conserved Domains (1) summary
    cd00014
    Location:848 → 917
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

  2. NM_001297817.1 → NP_001284746.1  split discs, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284746.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U4H0, X2JHS3
    Conserved Domains (1) summary
    cd00014
    Location:847 → 947
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

  3. NM_130492.3 → NP_569848.2  split discs, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_569848.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U4H0, Q9W5E8, Q9W5E9
    Related
    FBpp0070156
    Conserved Domains (1) summary
    cd00014
    Location:848 → 948
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

  4. NM_001297818.1 → NP_001284747.1  split discs, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284747.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U4H0, Q9W5E8, Q9W5E9
    Conserved Domains (1) summary
    cd00014
    Location:848 → 948
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

  5. NM_001042789.2 → NP_001036254.1  split discs, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036254.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C7LA68, Q0KHX7
    Conserved Domains (2) summary
    cd00014
    Location:992 → 1092
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam13935
    Location:554 → 684
    Ead_Ea22; Ead/Ea22-like protein

  6. NM_001297819.1 → NP_001284748.1  split discs, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284748.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C7LA68, Q0KHX7
    Conserved Domains (2) summary
    cd00014
    Location:992 → 1092
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam13935
    Location:554 → 684
    Ead_Ea22; Ead/Ea22-like protein

  7. NM_001297816.1 → NP_001284745.1  split discs, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284745.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C7LA68, Q0KHX7
    Conserved Domains (2) summary
    cd00014
    Location:992 → 1092
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam13935
    Location:554 → 684
    Ead_Ea22; Ead/Ea22-like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O77431 O77431
Q0KHX7 Q0KHX7
Q9U4H0 Q9U4H0
Q9W5E8 Q9W5E8
X2J9Z8 X2J9Z8
X2JHS3 X2JHS3

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