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    ANXA7 annexin A7 [ Homo sapiens ]

    Gene ID: 310, updated on 11-May-2012

    Summary

    Official Symbol
    ANXA7provided by HGNC
    Official Full Name
    annexin A7provided by HGNC
    Primary source
    HGNC:545
    Locus tag
    RP11-537A6.8
    See related
    Ensembl:ENSG00000138279; HPRD:01720; MIM:186360; Vega:OTTHUMG00000018463
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SNX; ANX7; SYNEXIN
    Summary
    Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    10q22.2
    Sequence :
    Chromosome: 10; NC_000010.10 (75135189..75173841, complement)
    See ANXA7 in Epigenomics, MapViewer

    Chromosome 10 - NC_000010.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100652993 Neighboring gene DNAJC9 antisense RNA 1 (non-protein coding) Neighboring gene uncharacterized LOC100507212 Neighboring gene mitochondrial ribosomal protein S16 Neighboring gene tetratricopeptide repeat domain 18 Neighboring gene ribosomal protein L26 pseudogene 6 Neighboring gene MSS51 mitochondrial translational activator homolog (S. cerevisiae)

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P20073 O75340 PDCD6    HPRD  PubMed  
    P20073 P17252 PRKCA    HPRD  PubMed  
    P20073 P05771 PRKCB    HPRD  PubMed  
    P20073 P05129 PRKCG    HPRD  PubMed  
    P20073 P60903 S100A10    HPRD  PubMed  
    P20073 P30626 SRI    HPRD  PubMed  
    BioGRID:106807 BioGRID:106523 A1BG    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:106524 A2M    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:106575 ACTB    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:119529 ACTL6B    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:123586 ADAMTS10    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:124493 ALG2    BioGRID  PubMed Far Western; Reconstituted Complex 
    BioGRID:106807 BioGRID:106782 ANGPT2    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:106821 APC    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:106830 APLP1    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:106994 ATP5B    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:107007 ATP6V1A    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:110433 ATXN3    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:113647 BAG6    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:116332 C14orf1    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:121923 CCDC90B    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:115825 CCT7    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:107454 CDK4    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:116359 CELF3    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:107488 CENPB    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:107539 CHGB    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:112978 CLEC3B    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:107699 COL11A2    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:107681 COL4A2    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:107684 COL4A5    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:116176 COPS6    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:128695 CPNE2    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:114763 CPNE6    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:120310 CPSF3L    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:107790 CRMP1    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:119512 CSAD    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:107888 CTSB    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:117107 DDAH2    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:108100 DMPK    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:124527 DOCK7    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:108188 DVL1    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:108118 DYNC1I1    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:108237 EEF1A1    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:108433 EXT2    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:108460 F13A1    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:116298 FAF1    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:124100 FBN3    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:108535 FGB    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:123221 FLAD1    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:108868 GAPDH    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:108904 GBP2    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:108930 GDF9    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:109045 GNB2    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:115920 GNB5    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:109282 HADHB    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:116640 HMGXB3    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:109474 HOXD8    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:119720 INPP5K    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:127354 KLHL23    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:120905 LRIF1    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:119211 MED31    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:115104 MLL4    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:107213 MPPED1    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:110573 MSH2    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:110870 NGFR    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:114794 NMT2    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:115885 NPRL2    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:120751 OTUB1    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:123191 PAAF1    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:111188 PDHB    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:111332 PKM2    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:117173 PLD3    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:111672 PSMB10    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:111797 QARS    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:111863 RBBP4    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:123855 RBM48    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:112037 RPA1    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:112057 RPL13    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:112101 RPS2    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:119334 SDF4    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:119953 SEMA5B    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:115202 SETDB1    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:112493 SMPD1    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:109657 SP110    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:112595 SRI    BioGRID  PubMed Co-purification; Far Western 
    BioGRID:106807 BioGRID:112496 SUMO3    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:117998 TAF5L    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:117621 TIAM2    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:112943 TLE1    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:122447 TMEM108    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:112969 TMSB4X    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:113010 TP53    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:117968 TRMT2A    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:113603 TUBA1A    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:131483 TUBB2B    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:115654 TUBB3    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106807 BioGRID:113169 UBE2D1    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:119509 UCHL5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106807 BioGRID:114548 UNC119    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:113221 USP4    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:113272 VIM    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:121517 WDR18    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:124376 WDR73    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:113498 ZBTB16    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:113489 ZNF135    BioGRID  PubMed Two-hybrid 
    BioGRID:106807 BioGRID:128094 ZNF431    BioGRID  PubMed Two-hybrid 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    cellular water homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    hemostasis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    response to salt stress IEA
    Inferred from Electronic Annotation
    more info
     
    social behavior IEP
    Inferred from Expression Pattern
    more info
     
    Component Evidence Code Pubs
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    insoluble fraction IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    soluble fraction IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    annexin A7
    Names
    annexin A7
    annexin-7
    annexin VII

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001156.3NP_001147.1  annexin A7 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon, compared to variant 2, resulting in a shorter protein (isoform 1) that lacks an internal segment, compared to isoform 2.
      Source sequence(s)
      AL512656, AW518993, DC367313, J04543
      Consensus CDS
      CCDS7325.1
      UniProtKB/Swiss-Prot
      P20073
      Related
      ENSP00000362012, OTTHUMP00000019812, ENST00000372921, OTTHUMT00000048646
      Conserved Domains (1) summary
      cl02574
      Location:167232
      Blast Score: 272
      Annexin; Annexin
    2. NM_004034.2NP_004025.1  annexin A7 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
      Source sequence(s)
      AK312447, AL512656, AW518993, DC367313
      Consensus CDS
      CCDS7326.1
      UniProtKB/TrEMBL
      B2R657
      UniProtKB/Swiss-Prot
      P20073
      Related
      ENSP00000362010, OTTHUMP00000019813, ENST00000372919, OTTHUMT00000048647
      Conserved Domains (1) summary
      cl02574
      Location:189254
      Blast Score: 271
      Annexin; Annexin

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000010.10 Reference GRCh37.p5 Primary Assembly

      Range
      75135189..75173841, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000142.1 Alternate HuRef

      Range
      69129017..69167555, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

      Supplemental Content

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