HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 [Homo sapiens] - Gene

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Summary

Official Symbol: HIVEP2provided by HGNC
Official Full Name: human immunodeficiency virus type I enhancer binding protein 2provided by HGNC
Primary source: HGNC:4921
See related: Ensembl:ENSG00000010818; HPRD:00881; MIM:143054; Vega:OTTHUMG00000015713
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SHN2; ZAS2; MBP-2; MIBP1; ZNF40B; HIV-EP2
Summary: Members of the ZAS family, such as ZAS2 (HIVEP2), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM, Apr 2006]

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Genomic context

Location :: 6q23-q24

Sequence :: Chromosome: 6; NC_000006.11 (143072604..143266338, complement)

See HIVEP2 in Epigenomics, MapViewer

Chromosome 6 - NC_000006.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P31629	P22670	RFX1	HPRD	PubMed
BioGRID:109344	BioGRID:114457	BTRC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109344	BioGRID:116887	FBXW11	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109344	BioGRID:113188	SUMO1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109344	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109344	BioGRID:113363	YWHAE	BioGRID	PubMed	Two-hybrid
BioGRID:109344	BioGRID:113364	YWHAG	BioGRID	PubMed	Two-hybrid
BioGRID:109344	BioGRID:113366	YWHAZ	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
DNA binding	TAS Traceable Author Statement more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
regulation of transcription, DNA-dependent	NAS Non-traceable Author Statement more info

Component	Evidence Code	Pubs
intracellular	IEA Inferred from Electronic Annotation more info
nucleus	NAS Non-traceable Author Statement more info

General protein information

Preferred Names: transcription factor HIVEP2

Names: transcription factor HIVEP2; Schnurri-2; MHC binding protein-2; MHC-binding protein 2; c-myc intron binding protein 1; c-myc intron-binding protein 1; human immunodeficiency virus type I enhancer-binding protein 2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006734.3 → NP_006725.3 transcription factor HIVEP2

Status: PROVISIONAL

Source sequence(s)

AA041301, AA465317, AL023584, AW197846, CR936782, DA216380, X65644

Consensus CDS

CCDS43510.1

UniProtKB/Swiss-Prot

P31629

Related

ENSP00000356575, ENST00000367603

Conserved Domains (2) summary

pfam09770
Location:1093 – 1239
Blast Score: 96

PAT1; Topoisomerase II-associated protein PAT1

pfam13465
Location:204 – 228
Blast Score: 108

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000006.11 Reference GRCh37.p5 Primary Assembly

Range

143072604..143266338, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000138.1 Alternate HuRef

Range

140638941..140724428, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF153836.1	AAF81365.1
genomic	AL023584.1	CAA19042.1
genomic	AL355304.12 (100..20955)	None
genomic	AL355307.11 (100..40698)	None
genomic	CH471051.2	EAW47873.1
genomic	M60119.1	AAB88218.1
mRNA	AA041301.1	None
mRNA	AA465317.1	None
mRNA	AK226163.1	None
mRNA	AK296531.1	BAG59161.1
mRNA	AW197846.1	None
mRNA	BC032679.1	None
mRNA	CR936782.1	None
mRNA	DA216380.1	None
mRNA	DQ231041.1	ABB16331.1
mRNA	M61744.1	AAA36202.1
mRNA	X65644.1	CAA46596.1
other-genetic	BC167801.1	AAI67801.1