RT1-CE1 RT1 class I, locus1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: RT1-CE1provided by RGD
Full Name: RT1 class I, locus1provided by RGD
Primary source: RGD:1595869
See related: AllianceGenome:RGD:1595869
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RT1-C/E1; RT1-CE12
Summary: Predicted to enable peptide antigen binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 928.6), Spleen (RPKM 917.9) and 9 other tissues See more
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Genomic context

Location:: 20p12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (3560455..3564428, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (3555779..3559487, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables peptide antigen binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA Inferred from Biological aspect of Ancestor more info
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in lumenal side of endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RT1 class I, locus CE1

Names: MHC class I protein; RT1 class I, CE12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008832.2 → NP_001008832.1 RT1 class I, locus CE1 precursor

See identical proteins and their annotated locations for NP_001008832.1

Status: VALIDATED

Source sequence(s)

BX883046

UniProtKB/TrEMBL

A0A2P1NRX5, Q861Q4

Conserved Domains (3) summary

cd07698
Location:207 → 299

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

pfam00129
Location:25 → 203

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

pfam06623
Location:343 → 374

MHC_I_C; MHC_I C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

3560455..3564428 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098654.2 → XP_038954582.1 RT1 class I, locus CE1 isoform X1

UniProtKB/TrEMBL

A0A2P1NRX5

Conserved Domains (3) summary

pfam00129
Location:25 → 203

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

pfam06623
Location:343 → 367

MHC_I_C; MHC_I C-terminus

cd21016
Location:204 → 299

IgC1_MHC_Ib_T10_T22_like; Class Ib major histocompatibility complex (MHC) immunoglobulin domain of T10, T22, and similar proteins; member of the C1-set of Ig superfamily (IgSF) domains
XM_063279101.1 → XP_063135171.1 RT1 class I, locus CE1 isoform X3
XM_063279100.1 → XP_063135170.1 RT1 class I, locus CE1 isoform X2
XM_063279102.1 → XP_063135172.1 RT1 class I, locus CE1 isoform X4
XM_063279103.1 → XP_063135173.1 RT1 class I, locus CE1 isoform X5
XM_063279105.1 → XP_063135175.1 RT1 class I, locus CE1 isoform X6
XM_063279106.1 → XP_063135176.1 RT1 class I, locus CE1 isoform X6
XM_063279104.1 → XP_063135174.1 RT1 class I, locus CE1 isoform X5