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HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 [ Homo sapiens (human) ]

Gene ID: 3096, updated on 8-May-2016
Official Symbol
HIVEP1provided by HGNC
Official Full Name
human immunodeficiency virus type I enhancer binding protein 1provided by HGNC
Primary source
HGNC:HGNC:4920
See related
Ensembl:ENSG00000095951 HPRD:01925; MIM:194540; Vega:OTTHUMG00000014265
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAAP; ZAS1; CIRIP; MBP-1; ZNF40; CRYBP1; ZNF40A; PRDII-BF1; Schnurri-1
Summary
This gene encodes a transcription factor belonging to the ZAS family, members of which are large proteins that contain a ZAS domain - a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specifically to the DNA sequence motif, GGGACTTTCC, found in the enhancer elements of several viral promoters, including human immunodeficiency virus (HIV), and to related sequences found in the enhancer elements of a number of cellular promoters. This protein binds to this sequence motif, suggesting a role in the transcriptional regulation of both viral and cellular genes. [provided by RefSeq, Oct 2011]
Orthologs
Location:
6p24-p22.3
Exon count:
17
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (12007653..12164999)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (12012724..12212270)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724379 Neighboring gene uncharacterized LOC101928253 Neighboring gene endothelin 1 Neighboring gene uncharacterized LOC105374931

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics.
NHGRI GWA Catalog
Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat PRDII-BF1 activates HIV-1 gene expression and an antisense PRDII-BF1 construct inhibits Tat-induced HIV-1 gene expression, suggesting a role for PRDII-BF1 in enhancing Tat transactivation of the HIV-1 LTR promoter PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
RNA polymerase II distal enhancer sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
transcription regulatory region DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
transcription from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
zinc finger protein 40
Names
cirhin interaction protein
gate keeper of apoptosis-activating protein
major histocompatibility complex binding protein 1
positive regulatory domain II binding factor 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002114.3NP_002105.3  zinc finger protein 40

    See identical proteins and their annotated locations for NP_002105.3

    Status: VALIDATED

    Source sequence(s)
    AA563642, AI033710, AL391828, BC140816
    Consensus CDS
    CCDS43426.1
    UniProtKB/Swiss-Prot
    P15822
    Related
    ENSP00000368698, OTTHUMP00000016036, ENST00000379388, OTTHUMT00000039870
    Conserved Domains (6) summary
    pfam00096
    Location:20882110
    zf-C2H2; Zinc finger, C2H2 type
    pfam12756
    Location:21162182
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    pfam13465
    Location:21022127
    zf-H2C2_2; Zinc-finger double domain
    pfam13912
    Location:959984
    zf-C2H2_6; C2H2-type zinc finger
    sd00017
    Location:408427
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:20902110
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    12007653..12164999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514546.1XP_011512848.1  

    See identical proteins and their annotated locations for XP_011512848.1

    Conserved Domains (6) summary
    pfam00096
    Location:20972119
    zf-C2H2; Zinc finger, C2H2 type
    pfam12756
    Location:21252191
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    pfam13465
    Location:21112136
    zf-H2C2_2; Zinc-finger double domain
    pfam13912
    Location:968993
    zf-C2H2_6; C2H2-type zinc finger
    sd00017
    Location:417436
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:20992119
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_011514551.1XP_011512853.1  

    See identical proteins and their annotated locations for XP_011512853.1

    Conserved Domains (6) summary
    pfam00096
    Location:20882110
    zf-C2H2; Zinc finger, C2H2 type
    pfam12756
    Location:21162182
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    pfam13465
    Location:21022127
    zf-H2C2_2; Zinc-finger double domain
    pfam13912
    Location:959984
    zf-C2H2_6; C2H2-type zinc finger
    sd00017
    Location:408427
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:20902110
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_011514548.1XP_011512850.1  

    See identical proteins and their annotated locations for XP_011512850.1

    Conserved Domains (6) summary
    pfam00096
    Location:20972119
    zf-C2H2; Zinc finger, C2H2 type
    pfam12756
    Location:21252191
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    pfam13465
    Location:21112136
    zf-H2C2_2; Zinc-finger double domain
    pfam13912
    Location:968993
    zf-C2H2_6; C2H2-type zinc finger
    sd00017
    Location:417436
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:20992119
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_011514552.1XP_011512854.1  

    See identical proteins and their annotated locations for XP_011512854.1

    Conserved Domains (6) summary
    pfam00096
    Location:20882110
    zf-C2H2; Zinc finger, C2H2 type
    pfam12756
    Location:21162182
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    pfam13465
    Location:21022127
    zf-H2C2_2; Zinc-finger double domain
    pfam13912
    Location:959984
    zf-C2H2_6; C2H2-type zinc finger
    sd00017
    Location:408427
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:20902110
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_011514547.1XP_011512849.1  

    See identical proteins and their annotated locations for XP_011512849.1

    Conserved Domains (6) summary
    pfam00096
    Location:20972119
    zf-C2H2; Zinc finger, C2H2 type
    pfam12756
    Location:21252191
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    pfam13465
    Location:21112136
    zf-H2C2_2; Zinc-finger double domain
    pfam13912
    Location:968993
    zf-C2H2_6; C2H2-type zinc finger
    sd00017
    Location:417436
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:20992119
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. XM_011514549.1XP_011512851.1  

    See identical proteins and their annotated locations for XP_011512851.1

    Conserved Domains (6) summary
    pfam00096
    Location:20972119
    zf-C2H2; Zinc finger, C2H2 type
    pfam12756
    Location:21252191
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    pfam13465
    Location:21112136
    zf-H2C2_2; Zinc-finger double domain
    pfam13912
    Location:968993
    zf-C2H2_6; C2H2-type zinc finger
    sd00017
    Location:417436
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:20992119
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. XM_011514553.1XP_011512855.1  

    See identical proteins and their annotated locations for XP_011512855.1

    Conserved Domains (6) summary
    pfam00096
    Location:20882110
    zf-C2H2; Zinc finger, C2H2 type
    pfam12756
    Location:21162182
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    pfam13465
    Location:21022127
    zf-H2C2_2; Zinc-finger double domain
    pfam13912
    Location:959984
    zf-C2H2_6; C2H2-type zinc finger
    sd00017
    Location:408427
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:20902110
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. XM_011514550.1XP_011512852.1  

    See identical proteins and their annotated locations for XP_011512852.1

    Conserved Domains (6) summary
    pfam00096
    Location:20972119
    zf-C2H2; Zinc finger, C2H2 type
    pfam12756
    Location:21252191
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    pfam13465
    Location:21112136
    zf-H2C2_2; Zinc-finger double domain
    pfam13912
    Location:968993
    zf-C2H2_6; C2H2-type zinc finger
    sd00017
    Location:417436
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:20992119
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. XM_011514555.1XP_011512857.1  

    Conserved Domains (6) summary
    pfam00096
    Location:20772099
    zf-C2H2; Zinc finger, C2H2 type
    pfam12756
    Location:21052171
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    pfam13465
    Location:20912116
    zf-H2C2_2; Zinc-finger double domain
    pfam13912
    Location:948973
    zf-C2H2_6; C2H2-type zinc finger
    sd00017
    Location:397416
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:20792099
    ZF_C2H2; C2H2 Zn finger [structural motif]
  10. XM_011514545.1XP_011512847.1  

    Conserved Domains (6) summary
    pfam00096
    Location:21122134
    zf-C2H2; Zinc finger, C2H2 type
    pfam12756
    Location:21402206
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    pfam13465
    Location:21262151
    zf-H2C2_2; Zinc-finger double domain
    pfam13912
    Location:9831008
    zf-C2H2_6; C2H2-type zinc finger
    sd00017
    Location:432451
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:21142134
    ZF_C2H2; C2H2 Zn finger [structural motif]
  11. XM_011514554.1XP_011512856.1  

    Conserved Domains (6) summary
    pfam00096
    Location:20702092
    zf-C2H2; Zinc finger, C2H2 type
    pfam12756
    Location:20982164
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    pfam13465
    Location:20842109
    zf-H2C2_2; Zinc-finger double domain
    pfam13912
    Location:941966
    zf-C2H2_6; C2H2-type zinc finger
    sd00017
    Location:390409
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:20722092
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    12014828..12167353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)