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    Usp21 ubiquitin specific peptidase 21 [ Mus musculus (house mouse) ]

    Gene ID: 30941, updated on 5-May-2013
    Official Symbol
    Usp21provided by MGI
    Official Full Name
    ubiquitin specific peptidase 21provided by MGI
    Primary source
    MGI:1353665
    See related
    Ensembl:ENSMUSG00000053483; Vega:OTTMUSG00000021702
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Usp16; Usp23; ESTM28; W53272
    Location :
    1 H3; 1 79.3 cM
    Sequence :
    Chromosome: 1; NC_000067.6 (171281949..171287961, complement)
    See Usp21 in Epigenomics, MapViewer

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3 Neighboring gene protoporphyrinogen oxidase Neighboring gene ubiquitin-fold modifier conjugating enzyme 1 Neighboring gene ribosomal protein L27, pseudogene 1

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:206018 BioGRID:106605 ACVR1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:206018 BioGRID:112904 TGFBR1    BioGRID  PubMed Affinity Capture-Luminescence 

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NEDD8-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cysteine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin thiolesterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin thiolesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    histone deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IC
    Inferred by Curator
    more info
    PubMed 
    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 21
    Names
    ubiquitin carboxyl-terminal hydrolase 21
    ubiquitin thioesterase 21
    deubiquitinating enzyme 21
    ubiquitin thiolesterase 21
    ubiquitin specific protease 21
    ubiquitin specific protease 23
    ubiquitin-specific-processing protease 21
    NP_038947.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013919.4NP_038947.2  ubiquitin carboxyl-terminal hydrolase 21

      Status: VALIDATED

      Source sequence(s)
      AF177759, AK011148, BP770216, BY110597
      Consensus CDS
      CCDS35774.1
      UniProtKB/TrEMBL
      E9PUE2
      UniProtKB/Swiss-Prot
      Q9QZL6
      Related
      ENSMUSP00000064002, OTTMUSP00000024247, ENSMUST00000065941, OTTMUST00000051488
      Conserved Domains (3) summary
      cd02674
      Location:363557
      Blast Score: 569
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:213234
      Blast Score: 115
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:212556
      Blast Score: 687
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p1 C57BL/6J

      Range
      171281949..171287961, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000023.1 Alternate Mm_Celera

      Range
      173737971..173743991, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

      Supplemental Content

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