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HINT1 histidine triad nucleotide binding protein 1 [ Homo sapiens (human) ]

Gene ID: 3094, updated on 19-Nov-2014
Official Symbol
HINT1provided by HGNC
Official Full Name
histidine triad nucleotide binding protein 1provided by HGNC
Primary source
HGNC:HGNC:4912
See related
HPRD:03204; MIM:601314
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HINT; NMAN; PKCI-1; PRKCNH1
Summary
The protein encoded by this gene can hydrolyze substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif, which is part of the loop that binds to the substrate. This gene has been found to be a tumor suppressing gene. Several transcript variants, but only one of them protein-coding, have been found for this gene. [provided by RefSeq, Dec 2012]
See HINT1 in Epigenomics, MapViewer
Location:
5q31.2
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 5 NC_000005.10 (131159283..131165348, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (130494976..130501041, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene splicing factor 4 pseudogene Neighboring gene ribosomal protein L11 pseudogene 2 Neighboring gene LYR motif containing 7 Neighboring gene CDC42 small effector 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Genes, including GABRP, ADF, HINT, PRSS2, SDCBP, PTK9, PPP2R5B, ITGA3, PRKCBP1, HMOX2, HAT1, PPP1cB, and ICAM-1, are upregulated after treatment of human astrocytes with HIV-1 gp120 PubMed
Tat tat Expression of HIV-1 Tat upregulates the abundance of histidine triad nucleotide binding protein 1 (HINT1) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ30414, FLJ32340

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase C binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
intrinsic apoptotic signaling pathway by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
purine ribonucleotide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylase complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
Preferred Names
histidine triad nucleotide-binding protein 1
Names
histidine triad nucleotide-binding protein 1
protein kinase C inhibitor 1
adenosine 5'-monophosphoramidase
protein kinase C-interacting protein 1
NP_005331.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032998.1 

    Range
    5001..11066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005340.6NP_005331.1  histidine triad nucleotide-binding protein 1

    See proteins identical to NP_005331.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AA076103, BC007090, BF967059
    Consensus CDS
    CCDS4147.1
    UniProtKB/Swiss-Prot
    P49773
    Conserved Domains (1) summary
    cd01276
    Location:16118
    PKCI_related; Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a ...

RNA

  1. NR_024610.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA076103, BC028300, BF967059
  2. NR_024611.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' exon, compared to variant 1. This variant is represented as non-coding because there is uncertainty about the protein-coding capacity of the transcript.
    Source sequence(s)
    AA076103, BF967059, CK002748, CN290239
  3. NR_073488.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' exon and includes two alternate internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA076103, AC004650, BF967059, CD639104, CN290239

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Alternate HuRef

Genomic

  1. AC_000137.1 

    Range
    125686002..125692067
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000005.10 

    Range
    131159283..131165348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 

    Range
    129927969..129934034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)