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Chuk conserved helix-loop-helix ubiquitous kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 309361, updated on 17-May-2016
Official Symbol
Chukprovided by RGD
Official Full Name
conserved helix-loop-helix ubiquitous kinaseprovided by RGD
Primary source
RGD:1306661
See related
Ensembl:ENSRNOG00000022485
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Ikka; Ikbka
Orthologs
Location:
1q54
Exon count:
22
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (263848829..263884354, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (271293821..271329346, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 23 Neighboring gene ER lipid raft associated 1 Neighboring gene CWF19-like 1, cell cycle control (S. pombe) Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to IkappaB kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
I-kappaB phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
lactation ISO
Inferred from Sequence Orthology
more info
 
mammary gland alveolus development ISO
Inferred from Sequence Orthology
more info
 
mammary gland epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
morphogenesis of an epithelial sheet ISO
Inferred from Sequence Orthology
more info
 
odontogenesis of dentin-containing tooth ISO
Inferred from Sequence Orthology
more info
 
osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
response to acetate IEP
Inferred from Expression Pattern
more info
PubMed 
response to amino acid IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to hydroperoxide IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
response to muscle stretch ISO
Inferred from Sequence Orthology
more info
 
response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
response to toxic substance IEP
Inferred from Expression Pattern
more info
PubMed 
skeletal muscle contraction IEP
Inferred from Expression Pattern
more info
PubMed 
striated muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
CD40 receptor complex ISO
Inferred from Sequence Orthology
more info
 
IkappaB kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
inhibitor of nuclear factor kappa-B kinase subunit alpha
NP_001101058.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107588.1NP_001101058.1  inhibitor of nuclear factor kappa-B kinase subunit alpha

    See identical proteins and their annotated locations for NP_001101058.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473986
    UniProtKB/TrEMBL
    G3V926
    Related
    ENSRNOP00000034134, ENSRNOT00000030782
    Conserved Domains (3) summary
    pfam12179
    Location:706743
    IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain
    smart00220
    Location:15287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14039
    Location:21309
    STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    263848829..263884354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231481.2XP_006231543.1  

    See identical proteins and their annotated locations for XP_006231543.1

    UniProtKB/TrEMBL
    B5DF32
    Conserved Domains (2) summary
    smart00220
    Location:15287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14039
    Location:21309
    STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha
  2. XM_008760419.1XP_008758641.1  

    See identical proteins and their annotated locations for XP_008758641.1

    Conserved Domains (2) summary
    smart00220
    Location:15287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14039
    Location:21309
    STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha
  3. XM_008760418.1XP_008758640.1  

    See identical proteins and their annotated locations for XP_008758640.1

    Conserved Domains (2) summary
    smart00220
    Location:15287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14039
    Location:21309
    STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    238777027..238812551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)