Format

Send to:

Choose Destination

Smpd1 sphingomyelin phosphodiesterase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308909, updated on 26-May-2016
Official Symbol
Smpd1provided by RGD
Official Full Name
sphingomyelin phosphodiesterase 1provided by RGD
Primary source
RGD:1549719
See related
Ensembl:ENSRNOG00000017977
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Orthologs
Location:
1q33
Exon count:
6
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (170383682..170387525)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (177389588..177393431)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene cholecystokinin B receptor Neighboring gene protein kinase C, delta binding protein Neighboring gene amyloid beta precursor protein binding family B member 1 Neighboring gene hemopexin

Markers

Homology

Clone Names

  • MGC94748

Gene Ontology Provided by RGD

Function Evidence Code Pubs
acid sphingomyelin phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
sphingomyelin phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
ceramide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
ceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
response to cocaine IDA
Inferred from Direct Assay
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
sphingomyelin catabolic process IEA
Inferred from Electronic Annotation
more info
 
sphingomyelin catabolic process ISO
Inferred from Sequence Orthology
more info
 
termination of signal transduction IEA
Inferred from Electronic Annotation
more info
 
termination of signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
endosome IEA
Inferred from Electronic Annotation
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lamellar body IDA
Inferred from Direct Assay
more info
PubMed 
lysosome IEA
Inferred from Electronic Annotation
more info
 
lysosome ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
sphingomyelin phosphodiesterase
Names
sphingomyelin phosphodiesterase 1, acid lysosomal
NP_001006998.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006997.1NP_001006998.1  sphingomyelin phosphodiesterase

    See identical proteins and their annotated locations for NP_001006998.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083780
    UniProtKB/TrEMBL
    Q5XIA6
    Related
    ENSRNOP00000024224, ENSRNOT00000024224
    Conserved Domains (3) summary
    smart00741
    Location:85158
    SapB; Saposin (B) Domains
    COG1409
    Location:254517
    CpdA; 3',5'-cyclic AMP phosphodiesterase CpdA [Signal transduction mechanisms]
    cd00842
    Location:199494
    MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    170383682..170387525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    157825620..157829463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)