PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 [Homo sapiens] - Gene

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Summary

Official Symbol: PIK3R4provided by HGNC
Official Full Name: phosphoinositide-3-kinase, regulatory subunit 4provided by HGNC
Primary source: HGNC:8982
See related: Ensembl:ENSG00000196455; HPRD:04010; MIM:602610; Vega:OTTHUMG00000159645
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: p150; VPS15; MGC102700

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Genomic context

Location :: 3q22.1

Sequence :: Chromosome: 3; NC_000003.11 (130397778..130465696, complement)

See PIK3R4 in Epigenomics, MapViewer

Chromosome 3 - NC_000003.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A specific sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates both receptor degradation and cytokinesis, whereas ATG14L, a PI3K-III subunit involved in autophagy, is not required.
Title: A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.
hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells
Title: hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q99570	Q15691	MAPRE1	HPRD	PubMed
Q99570	Q8NEB9	PIK3C3	HPRD	PubMed
Q99570	P31946	YWHAB	HPRD	PubMed
BioGRID:119059	BioGRID:116531	ATG14	BioGRID	PubMed	Affinity Capture-MS
BioGRID:119059	BioGRID:114226	BECN1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:119059	BioGRID:107330	KRIT1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:119059	BioGRID:136855	MAP1LC3C	BioGRID	PubMed	Affinity Capture-MS
BioGRID:119059	BioGRID:111307	PIK3C3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:119059	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:119059	BioGRID:113248	UVRAG	BioGRID	PubMed	Affinity Capture-MS
BioGRID:119059	BioGRID:113361	YWHAB	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	NAS Non-traceable Author Statement more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase activity	NAS Non-traceable Author Statement more info	PubMed
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
innate immune response	TAS Traceable Author Statement more info
insulin receptor signaling pathway	TAS Traceable Author Statement more info
protein phosphorylation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytosol	TAS Traceable Author Statement more info
late endosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: phosphoinositide 3-kinase regulatory subunit 4

Names: phosphoinositide 3-kinase regulatory subunit 4; PI3-kinase p150 subunit; PI3-kinase regulatory subunit 4; phosphoinositide 3-kinase adaptor protein; phosphatidylinositol 3-kinase-associated p150; phosphoinositide-3-kinase, regulatory subunit 4, p150

NP_055417.1

EC 2.7.11.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014602.2 → NP_055417.1 phosphoinositide 3-kinase regulatory subunit 4

Status: VALIDATED

Source sequence(s)

BP359657, Y08991

Consensus CDS

CCDS3067.1

UniProtKB/Swiss-Prot

Q99570

Related

ENSP00000349205, OTTHUMP00000216091, ENST00000356763, OTTHUMT00000356668

Conserved Domains (3) summary

cd00180
Location:32 – 310
Blast Score: 219

PKc; Catalytic domain of Protein Kinases

smart00220
Location:26 – 309
Blast Score: 204

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl02567
Location:985 – 1269
Blast Score: 221

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000003.11 Reference GRCh37.p5 Primary Assembly

Range

130397778..130465696, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000135.1 Alternate HuRef

Range

127782400..127850320, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC097105.10 (105779..109117)	None
genomic	AC128683.3 (16141..80669)	None
genomic	CH471052.2	EAW79222.1
genomic	FB775516.1	CAV30715.1
mRNA	AK314219.1	BAG36893.1
mRNA	BC009899.2	None
mRNA	BC017332.2	None
mRNA	BC057239.1	None
mRNA	BC069191.1	None
mRNA	BC110318.1	AAI10319.1
mRNA	BC127105.1	AAI27106.1
mRNA	BC127106.1	AAI27107.1
mRNA	BP359657.1	None
mRNA	Y08991.1	CAA70176.1