NRG1 neuregulin 1 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: NRG1provided by HGNC
Official Full Name: neuregulin 1provided by HGNC
Primary source: HGNC:7997
See related: Ensembl:ENSG00000157168; HPRD:00802; MIM:142445; Vega:OTTHUMG00000163918
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF; MST131
Summary: The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD). [provided by RefSeq, May 2009]

Genomic context

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Location :: 8p12

Sequence :: Chromosome: 8; NC_000008.10 (31496820..32622558)

See NRG1 in Epigenomics, MapViewer

Chromosome 8 - NC_000008.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

This review discusses an association of NRG1 supporting the hypothesis that genes acting in neurodevelopment confer liability to psychosis, which is unmasked during the neuropathological processes associated with Alzheimer's disease.
Title: Missense substitutions associated with behavioural disturbances in Alzheimer's disease (AD).
our data suggest that Nrg1 regulates L1 expression in gliomas
Title: Neuregulin 1 enhances cell adhesion molecule l1 expression in human glioma cells and promotes their migration as a function of malignancy.
Bipolar I disorder and schizophrenia share a number of common genetic risk loci and susceptibility genes including the genes coding for neuregulin 1 (NRG1).
Title: The association of white matter volume in psychotic disorders with genotypic variation in NRG1, MOG and CNP: a voxel-based analysis in affected individuals and their unaffected relatives.
NRG-1 activates PI3K/Akt signaling and inhibits mitochondrial permeability transition pore opening.
Title: Neuregulin-1 suppresses cardiomyocyte apoptosis by activating PI3K/Akt and inhibiting mitochondrial permeability transition pore.
We found a novel intronic five-SNP haplotype ~730 kb upstream of the type I promoter and determined that this region functions as transcriptional enhancer that is suppressed by SRY.
Title: Schizophrenia-associated HapICE haplotype is associated with increased NRG1 type III expression and high nucleotide diversity.
Suggest that NRG-1 gene transduction can improve cardiac function by promoting angiogenesis and preventing apoptosis in myocardial infarction.
Title: Therapeutic effects of neuregulin-1 gene transduction in rats with myocardial infarction.
NRG1 polymorphisms/haplotypes do not play a major role in the risk of schizophrenia in a Korean ethnic group.
Title: Lack of associations of neuregulin 1 variations with schizophrenia and smooth pursuit eye movement abnormality in a Korean population.
This study showed that NRG1 is probably a susceptibility gene for CaD, based on convergent evidence of linkage and replicated associations in two independent AA samples.
Title: Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans.
the neuregulin 1-HER axis is a key mediator of hyperglycemic memory effects in breast cancer
Title: Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer.
Neuregulin mediates F-actin-driven cell migration through inhibition of protein kinase D1 via Rac1 protein
Title: Neuregulin mediates F-actin-driven cell migration through inhibition of protein kinase D1 via Rac1 protein.

Submit: New GeneRIF Correction See all (237)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Discovery of common variants associated with low TSH levels and thyroid cancer risk.

Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.

Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease.

Genome-wide association with bone mass and geometry in the Framingham Heart Study.

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_039258.1	NP_001973.1	ERBB3	BIND	PubMed	NDF-alpha interacts with Her3. An interaction between human NDF-alpha and Her3 from an unknown species was demonstrated by experimental system.
Q02297	Q9H013	ADAM19	HPRD	PubMed
Q02297	P01133	EGF	HPRD	PubMed
Q02297	P21860	ERBB3	HPRD	PubMed
Q02297	Q15303	ERBB4	HPRD	PubMed
Q02297	Zinc finger protein, subfamily 1A, member 4	IKZF4	HPRD	PubMed
Q02297	P53667	LIMK1	HPRD	PubMed
	NT_010718.15	DLG4	BIND	PubMed	Nrg-1 interacts with PSD-95 promoter. This interaction was modeled on a demonstrated interaction between Nrg-1 from an unspecified species and human PSD-95 promoter.
BioGRID:109332	BioGRID:108276	EGFR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109332	BioGRID:108376	ERBB2	BioGRID	PubMed	Reconstituted Complex
BioGRID:109332	BioGRID:108377	ERBB3	BioGRID	PubMed	Reconstituted Complex
BioGRID:109332	BioGRID:108378	ERBB4	BioGRID	PubMed	Reconstituted Complex
	NP_071910.2	IKZF4	BIND	PubMed	Nrg-1 interacts with Eos. This interaction was modeled on a demonstrated interaction between Nrg-1 from an unspecified species and Eos from an unspecified species.
BioGRID:109332	BioGRID:110172	LIMK1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid

Pathways from BioSystems

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Adaptive Immune System, organism-specific biosystem (from REACTOME)
Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
Cardiac Progenitor Differentiation, organism-specific biosystem (from WikiPathways)
Cardiac Progenitor Differentiation, organism-specific biosystemFactors involved in the induction of cardiac differentiation in vitro and in vivo. This model was based on the below two review articles.
Constitutive PI3K/AKT Signaling in Cancer, organism-specific biosystem (from REACTOME)
Constitutive PI3K/AKT Signaling in Cancer, organism-specific biosystemClass IA PI3K is a heterodimer of a p85 regulatory subunit (encoded by PIK3R1, PIK3R2 or PIK3R3) and a p110 catalytic subunit (encoded by PIK3CA, PIK3CB or PIK3CD). In the absence of activating signa...
DAP12 interactions, organism-specific biosystem (from REACTOME)
DAP12 interactions, organism-specific biosystemDNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cel...
DAP12 signaling, organism-specific biosystem (from REACTOME)
DAP12 signaling, organism-specific biosystemIn response to receptor ligation, the tyrosine residues in DAP12's immunoreceptor tyrosine-based activation motif (ITAM) are phosphorylated by Src family kinases. These phosphotyrosines form the dock...
Disease, organism-specific biosystem (from REACTOME)
Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
Downregulation of ERBB2:ERBB3 signaling, organism-specific biosystem (from REACTOME)
Downregulation of ERBB2:ERBB3 signaling, organism-specific biosystemLevel of plasma membrane ERBB3 is regulated by E3 ubiquitin ligase RNF41 (also known as NRDP1), which binds and ubiquitinates both inactive and activated ERBB3, targeting it for degradation (Cao et a...
Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystemSecond messengers (calcium, diacylglycerol, inositol 1,4,5-trisphosphate, and phosphatidyinositol 3,4,5-trisphosphate) trigger signaling pathways: NF-kappaB is activated via protein kinase C beta, RA...
Downstream signal transduction, organism-specific biosystem (from REACTOME)
Downstream signal transduction, organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of aro...
Downstream signaling of activated FGFR, organism-specific biosystem (from REACTOME)
Downstream signaling of activated FGFR, organism-specific biosystemSignaling via FGFRs is mediated via direct recruitment of signaling proteins that bind to tyrosine auto-phosphorylation sites on the activated receptor and via closely linked docking proteins that be...
ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
ErbB signaling pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
ErbB signaling pathway, organism-specific biosystem (from KEGG)
ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
ErbB signaling pathway, conserved biosystem (from KEGG)
ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
GAB1 signalosome, organism-specific biosystem (from REACTOME)
GAB1 signalosome, organism-specific biosystemGAB1 is recruited to the activated EGFR indirectly, through GRB2. GAB1 acts as an adaptor protein that enables formation of an active PIK3, through recruitment of PIK3 regulatory subunit PIK3R1 (also...
GRB2 events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
GRB2 events in ERBB2 signaling, organism-specific biosystemERBB2:EGFR and ERBB2:ERBB4 can directly recruit GRB2:SOS1 complex through phosphorylated C-tail tyrosines of EGFR (Y1068 and Y1086) and ERBB2 (Y1139) that serve as docking sites for GRB2 (Xie et al. ...
GRB7 events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
GRB7 events in ERBB2 signaling, organism-specific biosystemHeterodimers of ERBB2 and ERBB3 are able to bind GRB7 (Fiddes et al. 1998) through phosphorylated tyrosine residues in the C-tail of ERBB3 (Y1199 and Y1262), but the exact downstream signaling of thi...
Glypican 1 network, organism-specific biosystem (from Pathway Interaction Database)
Glypican 1 network, organism-specific biosystem
Glypican 1 network
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lin...
NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
Nuclear signaling by ERBB4, organism-specific biosystem (from REACTOME)
Nuclear signaling by ERBB4, organism-specific biosystemBesides signaling as a transmembrane receptor, ligand activated homodimers of ERBB4 JM-A isoforms (ERBB4 JM-A CYT1 and ERBB4 JM-A CYT2) undergo proteolytic cleavage by ADAM17 (TACE) in the juxtamembr...
PI-3K cascade, organism-specific biosystem (from REACTOME)
PI-3K cascade, organism-specific biosystemThe ability of growth factors to protect from apoptosis is primarily due to the activation of the AKT survival pathway. P-I-3-kinase dependent activation of PDK leads to the activation of AKT which i...
PI3K events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
PI3K events in ERBB2 signaling, organism-specific biosystemERBB2:ERBB3 and ERBB2:ERBB4cyt1 heterodimers activate PI3K signaling by direct binding of PI3K regulatory subunit p85 (Yang et al. 2007, Cohen et al. 1996, Kaushansky et al. 2008) to phosphorylated t...
PI3K events in ERBB4 signaling, organism-specific biosystem (from REACTOME)
PI3K events in ERBB4 signaling, organism-specific biosystemThe CYT1 isoforms of ERBB4 possess a C-tail tyrosine residue that, upon trans-autophosphorylation, serves as a docking site for the p85 alpha subunit of PI3K - PIK3R1 (Kaushansky et al. 2008, Cohen e...
PI3K/AKT Signaling in Cancer, organism-specific biosystem (from REACTOME)
PI3K/AKT Signaling in Cancer, organism-specific biosystemThis pathway describes how normal signaling by PI3K/AKT, presented in the contained module 'PIP3 Activates AKT Signaling' and recently reviewed by Manning and Cantley in 2007, is perturbed in cancer,...
PI3K/AKT activation, organism-specific biosystem (from REACTOME)
PI3K/AKT activation, organism-specific biosystemPI3K/AKT signalling is a major regulator of neuron survival. It blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell...
PIP3 activates AKT signaling, organism-specific biosystem (from REACTOME)
PIP3 activates AKT signaling, organism-specific biosystemSignaling by AKT is one of the key outcomes of receptor tyrosine kinase (RTK) activation. AKT is activated by the cellular second messenger PIP3, a phospholipid that is generated by PI3K. In ustimula...
SHC1 events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
SHC1 events in ERBB2 signaling, organism-specific biosystemAll ERBB2 heterodimers, ERBB2:EGFR, ERBB2:ERBB3 and ERBB2:ERBB4, are able to activate RAF/MAP kinase cascade by recruiting SHC1 (Pinkas-Kramarski et al. 1996, Sepp-Lorenzino et al. 1996) to phosphory...
SHC1 events in ERBB4 signaling, organism-specific biosystem (from REACTOME)
SHC1 events in ERBB4 signaling, organism-specific biosystemAll splicing isoforms of ERBB4 possess two tyrosine residues in the C-tail that serve as docking sites for SHC1 (Kaushansky et al. 2008, Pinkas-Kramarski et al. 1996, Cohen et al. 1996). Once bound t...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by EGFR, organism-specific biosystem (from REACTOME)
Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
Signaling by EGFR in Cancer, organism-specific biosystemThe pathway "Signaling by EGFR in Cancer" shows "Signaling by constitutively active EGFR" in parallel with "Signaling by EGFR". This allows users to compare signaling by constitutively active EGFR ca...
Signaling by ERBB2, organism-specific biosystem (from REACTOME)
Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
Signaling by ERBB4, organism-specific biosystem (from REACTOME)
Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
Signaling by FGFR, organism-specific biosystem (from REACTOME)
Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
Signaling by FGFR in disease, organism-specific biosystem (from REACTOME)
Signaling by FGFR in disease, organism-specific biosystemThe pathway 'Signaling by FGFR in disease' shows 'Signaling by FGFR mutants' in parallel with the wild-type pathway 'Signaling by FGFR', allowing users to compare disease and normal events. FGFR mut...
Signaling by PDGF, organism-specific biosystem (from REACTOME)
Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
Signalling by NGF, organism-specific biosystem (from REACTOME)
Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...

General gene information

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Markers

SHGC-78993 (e-PCR)
- UniSTS:101377

RH120054 (e-PCR)
- UniSTS:133378

RH11877 (e-PCR)
- UniSTS:4618

RH65488 (e-PCR)
- UniSTS:80412

L30054 (e-PCR)
- UniSTS:74528

RH123550 (e-PCR)
- UniSTS:135970

G63471 (e-PCR)
- UniSTS:140583

Nrg1 (e-PCR), detects polymorphism
- UniSTS:468009

UniSTS:468010 (e-PCR)
- UniSTS:468010

Nrg1 (e-PCR), detects polymorphism
- UniSTS:468010

RH35824 (e-PCR)
- UniSTS:24633

G30982 (e-PCR)
- UniSTS:57923

D8S278 (e-PCR), detects polymorphism
- UniSTS:22596

D8S375 (e-PCR), detects polymorphism
- UniSTS:76616

AFMA143YG9 (e-PCR)
- UniSTS:21075

SHGC-80823 (e-PCR)
- UniSTS:102483

STS-Z40930 (e-PCR)
- UniSTS:33116

SHGC-82537 (e-PCR)
- UniSTS:100702

SHGC-142734 (e-PCR)
- UniSTS:171619

D8S278 (e-PCR), detects polymorphism
- UniSTS:69227

D8S2063 (e-PCR)
- UniSTS:53869

G63290 (e-PCR)
- UniSTS:140403

G17227 (e-PCR)
- UniSTS:8325

RH98441 (e-PCR)
- UniSTS:89740

D8S1477 (e-PCR)
- UniSTS:12687

D8S499 (e-PCR)
- UniSTS:54672

G59016 (e-PCR)
- UniSTS:136340

D8S1810 (e-PCR), detects polymorphism
- UniSTS:19361

RH119663 (e-PCR)
- UniSTS:133032

SHGC-12780 (e-PCR)
- UniSTS:40881

WI-18803 (e-PCR)
- UniSTS:72652

D8S1125 (e-PCR)
- UniSTS:31697

SHGC-142477 (e-PCR)
- UniSTS:171477

G27359 (e-PCR)
- UniSTS:1242

SHGC-142912 (e-PCR)
- UniSTS:171739

SHGC-81230 (e-PCR)
- UniSTS:102366

RH120019 (e-PCR)
- UniSTS:133343

RH122857 (e-PCR)
- UniSTS:135155

HSC1IA022 (e-PCR)
- UniSTS:32758

Genotypes

See NRG1 SNP Geneview Report
See NRG1 SNP Genotype Report
See NRG1 SNP Variation Viewer Report

Homology

OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
ErbB-2 class receptor binding	IEA Inferred from Electronic Annotation more info
ErbB-3 class receptor binding	IDA Inferred from Direct Assay more info	PubMed
ErbB-3 class receptor binding	IPI Inferred from Physical Interaction more info	PubMed
cytokine activity	TAS Traceable Author Statement more info	PubMed
growth factor activity	IDA Inferred from Direct Assay more info	PubMed
growth factor activity	NAS Non-traceable Author Statement more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein tyrosine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
receptor binding	IPI Inferred from Physical Interaction more info	PubMed
receptor tyrosine kinase binding	NAS Non-traceable Author Statement more info	PubMed
transcription cofactor activity	IDA Inferred from Direct Assay more info	PubMed
transmembrane receptor protein tyrosine kinase activator activity	IC Inferred by Curator more info	PubMed
transmembrane receptor protein tyrosine kinase activator activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
ERBB signaling pathway	IDA Inferred from Direct Assay more info	PubMed
MAPK cascade	IEA Inferred from Electronic Annotation more info
activation of transmembrane receptor protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
activation of transmembrane receptor protein tyrosine kinase activity	NAS Non-traceable Author Statement more info	PubMed
cardiac conduction system development	IEA Inferred from Electronic Annotation more info
cardiac muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
cardiac muscle cell myoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
cell communication	TAS Traceable Author Statement more info	PubMed
cell migration	IEA Inferred from Electronic Annotation more info
cell morphogenesis	IEA Inferred from Electronic Annotation more info
cell proliferation	IDA Inferred from Direct Assay more info	PubMed
cellular protein complex disassembly	IGI Inferred from Genetic Interaction more info	PubMed
embryo development	IEA Inferred from Electronic Annotation more info
endocardial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
epidermal growth factor receptor signaling pathway	TAS Traceable Author Statement more info
fibroblast growth factor receptor signaling pathway	TAS Traceable Author Statement more info
glial cell differentiation	IEA Inferred from Electronic Annotation more info
innate immune response	TAS Traceable Author Statement more info
locomotory behavior	IEA Inferred from Electronic Annotation more info
mammary gland development	TAS Traceable Author Statement more info	PubMed
negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cardiac muscle cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
negative regulation of secretion	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
nervous system development	TAS Traceable Author Statement more info	PubMed
neural crest cell development	TAS Traceable Author Statement more info	PubMed
neuron fate commitment	IEA Inferred from Electronic Annotation more info
neurotransmitter receptor metabolic process	IEA Inferred from Electronic Annotation more info
neurotrophin TRK receptor signaling pathway	TAS Traceable Author Statement more info
peripheral nervous system development	IEA Inferred from Electronic Annotation more info
phosphatidylinositol-mediated signaling	TAS Traceable Author Statement more info
positive regulation of Ras protein signal transduction	IEA Inferred from Electronic Annotation more info
positive regulation of cardiac muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein kinase B signaling cascade	IEA Inferred from Electronic Annotation more info
positive regulation of protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of striated muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
regulation of protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
regulation of protein homodimerization activity	TAS Traceable Author Statement more info	PubMed
synapse assembly	IEA Inferred from Electronic Annotation more info
transmembrane receptor protein tyrosine kinase signaling pathway	IDA Inferred from Direct Assay more info	PubMed
ventricular cardiac muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
ventricular trabecula myocardium morphogenesis	IDA Inferred from Direct Assay more info	PubMed
wound healing	IDA Inferred from Direct Assay more info	PubMed
wound healing	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IEA Inferred from Electronic Annotation more info
extracellular region	NAS Non-traceable Author Statement more info	PubMed
extracellular region	TAS Traceable Author Statement more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed
integral to plasma membrane	IEA Inferred from Electronic Annotation more info
membrane	NAS Non-traceable Author Statement more info	PubMed
neuromuscular junction	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pro-neuregulin-1, membrane-bound isoform

Names: pro-neuregulin-1, membrane-bound isoform; MSTP131; pro-NRG1; glial growth factor; neu differentiation factor; neuregulin 1 type IV beta 3; neuregulin 1 type IV beta 1a; sensory and motor neuron derived factor; heregulin, alpha (45kD, ERBB2 p185-activator)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012005.1 RefSeqGene

Range

4553..1130291

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001159995.1 → NP_001153467.1 pro-neuregulin-1, membrane-bound isoform isoform HRG-beta1c

Status: REVIEWED

Description

Transcript Variant: This variant (HRG-beta1c) has an alternate 5' exon and lacks an internal exon, compared to variant HRG-beta1. The resulting isoform (HRG-beta1c, also known as type IV fetal C beta 1a and fetal b IV-beta 1a) is shorter, and has a different N-terminus and lacks an internal segment, compared to isoform HRG-beta1.

Source sequence(s)

CN603654, DA805080, EF517297, M94166

UniProtKB/TrEMBL

A6MW56

UniProtKB/Swiss-Prot

Q02297

Conserved Domains (3) summary

pfam02158
Location:202 – 597
Blast Score: 1030

Neuregulin; Neuregulin family

cd05895
Location:32 – 106
Blast Score: 267

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

pfam07679
Location:18 – 108
Blast Score: 114

I-set; Immunoglobulin I-set domain
NM_001159996.1 → NP_001153468.1 pro-neuregulin-1, membrane-bound isoform isoform ndf43c

Status: REVIEWED

Description

Transcript Variant: This variant (ndf43c, also known as ndf43) lacks multiple 5' exons, but has an alternate 5' exon, an alternate internal segment and an additional exon in the 3' region, compared to variant HRG-beta1. The resulting isoform (ndf43c) is much shorter, and has alternate N- and C-termini and a different internal segment, compared to isoform HRG-beta1.

Source sequence(s)

AK293240, BC144446, DA805080, DC425692

UniProtKB/TrEMBL

B7Z1D7

Conserved Domains (2) summary

PHA03099
Location:28 – 120
Blast Score: 87

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

cl09941
Location:36 – 66
Blast Score: 77

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
NM_001159999.1 → NP_001153471.1 pro-neuregulin-1, membrane-bound isoform isoform HRG-beta1b

Status: REVIEWED

Description

Transcript Variant: This variant (HRG-beta1b) has an alternate 5' exon, compared to variant HRG-beta1. The resulting isoform (HRG-beta1b, also known as type IV fetal B beta 1a) is shorter, and has a different N-terminus, compared to isoform HRG-beta1.

Source sequence(s)

CN603652, DA805080, EF517296, M94165, U02328

UniProtKB/TrEMBL

A6MW55

UniProtKB/Swiss-Prot

Q02297

Conserved Domains (3) summary

pfam02158
Location:219 – 614
Blast Score: 1020

Neuregulin; Neuregulin family

cd05895
Location:32 – 106
Blast Score: 266

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

pfam07679
Location:18 – 108
Blast Score: 114

I-set; Immunoglobulin I-set domain
NM_001160001.1 → NP_001153473.1 pro-neuregulin-1, membrane-bound isoform isoform HRG-beta1d

Status: REVIEWED

Description

Transcript Variant: This variant (HRG-beta1d) has an alternate 5' exon and lacks two internal exons, compared to variant HRG-beta1. The resulting isoform (HRG-beta1d, also known as IV-beta 1a and type IV fetal A beta 1a) is shorter, and has a different N-terminus and lacks an internal segment, compared to isoform HRG-beta1.

Source sequence(s)

CN603654, DA805080, EF372273, M94165

Consensus CDS

CCDS55218.1

UniProtKB/Swiss-Prot

Q02297

Conserved Domains (3) summary

pfam02158
Location:185 – 580
Blast Score: 1028

Neuregulin; Neuregulin family

cd05895
Location:32 – 106
Blast Score: 265

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

pfam07679
Location:18 – 108
Blast Score: 115

I-set; Immunoglobulin I-set domain
NM_001160002.1 → NP_001153474.1 pro-neuregulin-1, membrane-bound isoform isoform HRG-gamma2

Status: REVIEWED

Description

Transcript Variant: This variant (HRG-gamma2) lacks an internal exon and multiple 3' exons, and has an alternate 3' UTR, compared to variant HRG-beta1. The resulting isoform (HRG-gamma2, also known as gamma protein isoform 1) lacks an internal segment and is C-terminal truncated, compared to isoform HRG-beta1.

Source sequence(s)

AC083977, AC103675, EU363508

UniProtKB/TrEMBL

B0FYA7

Conserved Domains (2) summary

pfam07679
Location:39 – 129
Blast Score: 113

I-set; Immunoglobulin I-set domain

cl11960
Location:53 – 127
Blast Score: 242

Ig; Immunoglobulin domain
NM_001160004.1 → NP_001153476.1 pro-neuregulin-1, membrane-bound isoform isoform ndf43b

Status: REVIEWED

Description

Transcript Variant: This variant (ndf43b, also called ndf43-beta2) lacks an internal exon, but has an additional exon in the 3' coding region, compared to variant HRG-beta1. The resulting isoform (ndf43b) is shorter, and lacks an internal segment and has a different C-terminus, compared to isoform HRG-beta1.

Source sequence(s)

AC083977, BC144446, DA805080, EU363510

UniProtKB/TrEMBL

B0FYA9

Conserved Domains (3) summary

PHA03099
Location:182 – 271
Blast Score: 90

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

pfam07679
Location:39 – 129
Blast Score: 114

I-set; Immunoglobulin I-set domain

cl11960
Location:53 – 127
Blast Score: 257

Ig; Immunoglobulin domain
NM_001160005.1 → NP_001153477.1 pro-neuregulin-1, membrane-bound isoform isoform HRG-beta3b

Status: REVIEWED

Description

Transcript Variant: This variant (HRG-beta3b) lacks two internal exons and multiple 3' exons, and has an alternate 3' sequence including the coding region and UTR, compared to variant HRG-beta1. The resulting isoform (HRG-beta3b, also known as HRG-beta 3 protein isoform) is much shorter, and lacks an internal segment and has a different C-terminus, compared to isoform HRG-beta1.

Source sequence(s)

AC083977, EU359055, M94168

UniProtKB/TrEMBL

B0FWZ3

UniProtKB/Swiss-Prot

Q02297

Conserved Domains (2) summary

pfam07679
Location:39 – 129
Blast Score: 114

I-set; Immunoglobulin I-set domain

cl11960
Location:53 – 127
Blast Score: 246

Ig; Immunoglobulin domain
NM_001160007.1 → NP_001153479.1 pro-neuregulin-1, membrane-bound isoform isoform HRG-gamma3

Status: REVIEWED

Description

Transcript Variant: This variant (HRG-gamma3) lacks two internal exons and multiple 3' exons, and has an alternate 3' UTR, compared to variant HRG-beta1. The resulting isoform (HRG-gamma3, also known as gamma protein isoform 2) lacks an internal segment and is C-terminal truncated, compared to isoform HRG-beta1.

Source sequence(s)

AC083977, AC103675, EU363509

UniProtKB/TrEMBL

B0FYA8

Conserved Domains (2) summary

pfam07679
Location:39 – 129
Blast Score: 114

I-set; Immunoglobulin I-set domain

cl11960
Location:53 – 127
Blast Score: 236

Ig; Immunoglobulin domain
NM_001160008.1 → NP_001153480.1 pro-neuregulin-1, membrane-bound isoform isoform HRG-beta2b

Status: REVIEWED

Description

Transcript Variant: This variant (HRG-beta2b) lacks an internal exon and the 3' exon, but has an alternate 3' UTR, compared to variant HRG-beta1. The resulting isoform (HRG-beta2b) lacks an internal segment and is C-terminal truncated, compared to isoform HRG-beta1.

Source sequence(s)

AK097005, AK298132, BC006492, BQ018711

Consensus CDS

CCDS55219.1

UniProtKB/TrEMBL

Q6PK61

Related

ENSP00000430120, OTTHUMP00000225419, ENST00000523079, OTTHUMT00000376466

Conserved Domains (4) summary

PHA03099
Location:182 – 271
Blast Score: 91

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

pfam07679
Location:39 – 129
Blast Score: 112

I-set; Immunoglobulin I-set domain

cl09941
Location:190 – 220
Blast Score: 74

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cl11960
Location:53 – 127
Blast Score: 255

Ig; Immunoglobulin domain
NM_004495.3 → NP_004486.2 pro-neuregulin-1, membrane-bound isoform isoform HRG-gamma

Status: REVIEWED

Description

Transcript Variant: This variant (HRG-gamma) lacks multiple 3' exons and has an alternate 3' UTR, compared to variant HRG-beta1. The resulting isoform (HRG-gamma) is C-terminal truncated, compared to isoform HRG-beta1.

Source sequence(s)

AC083977, AC103675, BC144446

UniProtKB/TrEMBL

Q7RTW5

Conserved Domains (2) summary

pfam07679
Location:39 – 129
Blast Score: 112

I-set; Immunoglobulin I-set domain

cl11960
Location:53 – 127
Blast Score: 242

Ig; Immunoglobulin domain
NM_013956.3 → NP_039250.2 pro-neuregulin-1, membrane-bound isoform isoform HRG-beta1

Status: REVIEWED

Description

Transcript Variant: This variant (HRG-beta1) is the longest transcript and encodes the longest isoform (HRG-beta1).

Source sequence(s)

AK097005, AK298132, BC006492, BC144446, DA805080, M94166

Consensus CDS

CCDS6083.1

UniProtKB/Swiss-Prot

Q02297

UniProtKB/TrEMBL

Q6PK61

Related

ENSP00000349275, ENST00000356819

Conserved Domains (3) summary

pfam02158
Location:240 – 635
Blast Score: 1005

Neuregulin; Neuregulin family

cd05750
Location:53 – 127
Blast Score: 261

Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins (NRGs)

pfam07679
Location:39 – 129
Blast Score: 114

I-set; Immunoglobulin I-set domain
NM_013957.3 → NP_039251.2 pro-neuregulin-1, membrane-bound isoform isoform HRG-beta2

Status: REVIEWED

Description

Transcript Variant: This variant (HRG-beta2) lacks an internal exon in the 3' coding region, compared to variant HRG-beta1. The resulting isoform (HRG-beta2) has identical N- and C-termini, but lacks an internal segment, compared to isoform HRG-beta1.

Source sequence(s)

AK097005, AK290730, AK298132, BC006492, DA805080, M94165

Consensus CDS

CCDS6084.1

UniProtKB/Swiss-Prot

Q02297

UniProtKB/TrEMBL

Q6PK61

UniProtKB/TrEMBL

Q7RTW3

Related

ENSP00000287842, OTTHUMP00000225420, ENST00000287842, OTTHUMT00000376467

Conserved Domains (4) summary

pfam02158
Location:232 – 627
Blast Score: 999

Neuregulin; Neuregulin family

cd05750
Location:53 – 127
Blast Score: 259

Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins (NRGs)

PHA03099
Location:182 – 271
Blast Score: 92

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

pfam07679
Location:39 – 129
Blast Score: 113

I-set; Immunoglobulin I-set domain
NM_013958.3 → NP_039252.2 pro-neuregulin-1, membrane-bound isoform isoform HRG-beta3

Status: REVIEWED

Description

Transcript Variant: This variant (HRG-beta3, also known as GGF or GGFHFB1) lacks multiple 3' exons, and has an alternate 3' sequence including the coding region and UTR, compared to variant HRG-beta1. The resulting isoform (HRG-beta3) is much shorter, and has a different C-terminus, compared to isoform HRG-beta1.

Source sequence(s)

AK097005, AK298132, M94165, M94168

UniProtKB/Swiss-Prot

Q02297

Conserved Domains (2) summary

pfam07679
Location:39 – 129
Blast Score: 112

I-set; Immunoglobulin I-set domain

cl11960
Location:53 – 127
Blast Score: 249

Ig; Immunoglobulin domain
NM_013959.3 → NP_039253.1 pro-neuregulin-1, membrane-bound isoform isoform SMDF

Status: REVIEWED

Description

Transcript Variant: This variant (SMDF) is expressed mainly in the nervous system. It lacks multiple 5' and 3' exons, but has an alternate 5' exon and an alternate 3' sequence including the coding region and UTR, compared to variant HRG-beta1. The resulting isoform (SMDF) is much shorter, and has different N- and C-termini, compared to isoform HRG-beta1.

Source sequence(s)

AK289927, M94168

Consensus CDS

CCDS6087.1

UniProtKB/Swiss-Prot

Q02297

Conserved Domains (1) summary

PHA02887
Location:236 – 279
Blast Score: 89

PHA02887; EGF-like protein; Provisional
NM_013960.3 → NP_039254.1 pro-neuregulin-1, membrane-bound isoform isoform ndf43

Status: REVIEWED

Description

Transcript Variant: This variant (ndf43) has an alternate internal segment and an additional exon in the 3' region, compared to variant HRG-beta1. The resulting isoform (ndf43) is shorter, and has a different internal segment and C-terminus, compared to isoform HRG-beta1.

Source sequence(s)

AK097005, AK298132, BC006492, DA805080, M94165, U02326

Consensus CDS

CCDS6086.1

UniProtKB/Swiss-Prot

Q02297

UniProtKB/TrEMBL

Q6PK61

Conserved Domains (4) summary

cd00054
Location:190 – 222
Blast Score: 81

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

PHA03099
Location:182 – 274
Blast Score: 89

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

pfam07679
Location:39 – 129
Blast Score: 114

I-set; Immunoglobulin I-set domain

cl11960
Location:53 – 127
Blast Score: 256

Ig; Immunoglobulin domain
NM_013962.2 → NP_039256.2 pro-neuregulin-1, membrane-bound isoform isoform GGF2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (GGF2, also called GGFHBS5) is expressed in the nervous system and functions as a neuronal signal that promotes the proliferation and survival of the oligodendrocyte and the myelinating cell. This variant lacks two internal exons and multiple 3' exons, and has an alternate 5' exon and an alternate 3' sequence including the coding region and UTR, compared to variant HRG-beta1. The resulting isoform (GGF2) is shorter, and has different N- and C- termini as well as lacks an internal segment, compared to isoform HRG-beta1.

Source sequence(s)

L12260, M94165, M94168

Consensus CDS

CCDS47836.1

UniProtKB/Swiss-Prot

Q02297

Related

ENSP00000434640, OTTHUMP00000230603, ENST00000520407, OTTHUMT00000376412

Conserved Domains (2) summary

cd05895
Location:268 – 342
Blast Score: 264

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

pfam07679
Location:254 – 344
Blast Score: 112

I-set; Immunoglobulin I-set domain
NM_013964.3 → NP_039258.1 pro-neuregulin-1, membrane-bound isoform isoform HRG-alpha

Status: REVIEWED

Description

Transcript Variant: This variant (HRG-alpha, also called erbB2) has an alternate internal segment, compared to variant HRG-beta1. The resulting isoform (HRG-alpha) is shorter, and has identical N- and C-termini and a different internal segment, compared to isoform HRG-beta1.

Source sequence(s)

AK097005, AK298132, BC006492, DA805080, M94165

Consensus CDS

CCDS6085.1

UniProtKB/Swiss-Prot

Q02297

UniProtKB/TrEMBL

Q6PK61

Related

ENSP00000287840, ENST00000287840

Conserved Domains (5) summary

cd00054
Location:190 – 222
Blast Score: 86

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam02158
Location:235 – 630
Blast Score: 993

Neuregulin; Neuregulin family

cd05750
Location:53 – 127
Blast Score: 258

Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins (NRGs)

PHA03099
Location:182 – 274
Blast Score: 90

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

pfam07679
Location:39 – 129
Blast Score: 113

I-set; Immunoglobulin I-set domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000008.10 Reference GRCh37.p10 Primary Assembly

Range

31496820..32622558

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000140.1 Alternate HuRef

Range

30042037..31167972

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018919.1 Alternate CHM1_1.0

Range

31733931..32859703

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01023619.1 (201115..252734)	None
genomic	ABBA01023620.1	None
genomic	ABBA01023621.1	None
genomic	ABBA01023622.1	None
genomic	ABBA01023623.1	None
genomic	ABBA01023624.1	None
genomic	ABBA01023625.1	None
genomic	ABBA01023626.1	None
genomic	ABBA01023627.1	None
genomic	ABBA01023628.1	None
genomic	ABBA01023629.1	None
genomic	ABBA01023630.1	None
genomic	ABBA01023631.1	None
genomic	ABBA01023632.1	None
genomic	ABBA01023633.1	None
genomic	ABBA01023634.1	None
genomic	ABBA01023635.1	None
genomic	AC021909.7 (85364..178621)	None
genomic	AC022833.5	None
genomic	AC022850.7	None
genomic	AC023948.13 (106635..195981)	None
genomic	AC068359.11 (35003..186457)	None
genomic	AC068931.6	None
genomic	AC083977.5 (81495..212555)	None
genomic	AC103675.2 (32806..109550)	None
genomic	AC104000.5 (92344..156855)	None
genomic	AC104029.5	None
genomic	AC113209.4 (167638..176176)	None
genomic	AF491780.1	AAM71137.1
		AAM71139.1
		AAM71140.1
genomic	AMYH01018625.1 (360438..746694)	None
genomic	AMYH01018626.1	None
genomic	AMYH01018627.1	None
genomic	AMYH01018628.1	None
genomic	BK000383.1	DAA00040.1
		DAA00041.1
		DAA00042.1
		DAA00043.1
		DAA00044.1
		DAA00045.1
		DAA00046.1
		DAA00047.1
		DAA00048.1
genomic	CH471080.2	EAW63407.1
		EAW63408.1
		EAW63409.1
		EAW63410.1
		EAW63411.1
		EAW63412.1
		EAW63413.1
		EAW63414.1
		EAW63415.1
		EAW63416.1
		EAW63417.1
		EAW63418.1
		EAW63419.1
mRNA	AB451331.1	BAG70145.1
mRNA	AB451475.1	BAG70289.1
mRNA	AF026146.1	AAD01795.1
mRNA	AF176921.1	AAQ13665.1
mRNA	AK097005.1	None
mRNA	AK223435.1	BAD97155.1
mRNA	AK289927.1	BAF82616.1
mRNA	AK290730.1	BAF83419.1
mRNA	AK293240.1	BAH11473.1
mRNA	AK293270.1	BAH11479.1
mRNA	AK298132.1	BAH12729.1
mRNA	AY207002.1	AAO49724.1
mRNA	BC006492.2	AAH06492.1
mRNA	BC007675.2	AAH07675.1
mRNA	BC064587.1	AAH64587.1
mRNA	BC073871.1	AAH73871.1
mRNA	BC144446.1	None
mRNA	BC150609.1	AAI50610.1
mRNA	BQ018711.1	None
mRNA	BT007389.1	AAP36053.1
mRNA	CN603652.1	None
mRNA	CN603654.1	None
mRNA	CR450288.1	CAG29284.1
mRNA	DA805080.1	None
mRNA	DC425692.1	None
mRNA	EF372273.1	ABQ53539.1
mRNA	EF372274.1	ABQ53540.1
mRNA	EF372275.1	ABQ53541.1
mRNA	EF372276.1	ABQ53542.1
mRNA	EF372277.1	ABQ53543.1
mRNA	EF517295.1	ABR13842.1
mRNA	EF517296.1	ABR13843.1
mRNA	EF517297.1	ABR13844.1
mRNA	EU359055.1	ABY70644.1
mRNA	EU363508.1	ABY66348.1
mRNA	EU363509.1	ABY66349.1
mRNA	EU363510.1	ABY66350.1
mRNA	GQ983557.1	ADN85612.1
mRNA	GQ983558.1	ADN85613.1
mRNA	L12260.1	AAB59622.1
mRNA	L12261.1	AAB59358.1
mRNA	L41827.1	AAC41764.1
mRNA	M94165.1	AAA58638.1
mRNA	M94166.1	AAA58639.1
mRNA	M94167.1	AAA58640.1
mRNA	M94168.1	AAA58641.1
mRNA	S68256.1	None
mRNA	U02325.1	AAA19950.1
mRNA	U02326.1	AAA19951.1
mRNA	U02327.1	AAA19952.1
mRNA	U02328.1	AAA19953.1
mRNA	U02329.1	AAA19954.1
mRNA	U02330.1	AAA19955.1