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NRG1 neuregulin 1 [ Homo sapiens (human) ]

Gene ID: 3084, updated on 16-Apr-2014
Official Symbol
NRG1provided by HGNC
Official Full Name
neuregulin 1provided by HGNC
Primary source
HGNC:7997
See related
Ensembl:ENSG00000157168; HPRD:00802; MIM:142445; Vega:OTTHUMG00000163918
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF; MST131
Summary
The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD). [provided by RefSeq, May 2009]
Location :
8p12
Sequence :
Chromosome: 8; NC_000008.11 (31639304..32765040)
See NRG1 in Epigenomics, MapViewer

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929492 Neighboring gene potassium channel tetramerization domain containing 9 pseudogene 6 Neighboring gene NRG1 intronic transcript 1 (non-protein coding) Neighboring gene NRG1 intronic transcript 3 (non-protein coding) Neighboring gene transfer RNA glutamine 43 (anticodon UUG) pseudogene Neighboring gene MT-ND1 pseudogene 6

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Schizophrenia 6
MedGen: C1864275 OMIM: 603013 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
NHGRI GWA Catalog
Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.
NHGRI GWA Catalog
Discovery of common variants associated with low TSH levels and thyroid cancer risk.
NHGRI GWA Catalog
Genetics of coronary artery calcification among African Americans, a meta-analysis.
NHGRI GWA Catalog
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
NHGRI GWA Catalog
Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease.
NHGRI GWA Catalog
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
NHGRI GWA Catalog
Genome-wide association with bone mass and geometry in the Framingham Heart Study.
NHGRI GWA Catalog
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ErbB-2 class receptor binding IEA
Inferred from Electronic Annotation
more info
 
ErbB-3 class receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
ErbB-3 class receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
cytokine activity TAS
Traceable Author Statement
more info
PubMed 
growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
growth factor activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor tyrosine kinase binding NAS
Non-traceable Author Statement
more info
PubMed 
transcription cofactor activity IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane receptor protein tyrosine kinase activator activity IC
Inferred by Curator
more info
PubMed 
transmembrane receptor protein tyrosine kinase activator activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
ERBB signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
activation of transmembrane receptor protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of transmembrane receptor protein tyrosine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
cardiac conduction system development IEA
Inferred from Electronic Annotation
more info
 
cardiac muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
cardiac muscle cell myoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
cell communication TAS
Traceable Author Statement
more info
PubMed 
cell migration IEA
Inferred from Electronic Annotation
more info
 
cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
cellular protein complex disassembly IGI
Inferred from Genetic Interaction
more info
PubMed 
embryo development IEA
Inferred from Electronic Annotation
more info
 
endocardial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
glial cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
innate immune response TAS
Traceable Author Statement
more info
 
locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
mammary gland development TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cardiac muscle cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of secretion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
neural crest cell development TAS
Traceable Author Statement
more info
PubMed 
neuron fate commitment IEA
Inferred from Electronic Annotation
more info
 
neurotransmitter receptor metabolic process IEA
Inferred from Electronic Annotation
more info
 
neurotrophin TRK receptor signaling pathway TAS
Traceable Author Statement
more info
 
peripheral nervous system development IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-mediated signaling TAS
Traceable Author Statement
more info
 
positive regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cardiac muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of striated muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein homodimerization activity TAS
Traceable Author Statement
more info
PubMed 
synapse assembly IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
ventricular cardiac muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
ventricular trabecula myocardium morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
wound healing IDA
Inferred from Direct Assay
more info
PubMed 
wound healing TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
axon IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
membrane NAS
Non-traceable Author Statement
more info
PubMed 
neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
pro-neuregulin-1, membrane-bound isoform
Names
pro-neuregulin-1, membrane-bound isoform
MSTP131
pro-NRG1
glial growth factor
neu differentiation factor
neuregulin 1 type IV beta 3
neuregulin 1 type IV beta 1a
sensory and motor neuron derived factor
heregulin, alpha (45kD, ERBB2 p185-activator)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012005.1 RefSeqGene

    Range
    4553..1130291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001159995.1NP_001153467.1  pro-neuregulin-1, membrane-bound isoform isoform HRG-beta1c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (HRG-beta1c) has an alternate 5' exon and lacks an internal exon, compared to variant HRG-beta1. The resulting isoform (HRG-beta1c, also known as type IV fetal C beta 1a and fetal b IV-beta 1a) is shorter, and has a different N-terminus and lacks an internal segment, compared to isoform HRG-beta1.
    Source sequence(s)
    CN603654, DA805080, EF517297, M94166
    UniProtKB/TrEMBL
    A6MW56
    UniProtKB/Swiss-Prot
    Q02297
    Conserved Domains (4) summary
    pfam02158
    Location:202597
    Blast Score: 1707
    Neuregulin; Neuregulin family
    cd05895
    Location:32106
    Blast Score: 362
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    smart00410
    Location:22108
    Blast Score: 155
    IG_like; Immunoglobulin like
    cd00054
    Location:152184
    Blast Score: 82
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  2. NM_001159996.1NP_001153468.1  pro-neuregulin-1, membrane-bound isoform isoform ndf43c

    See proteins identical to NP_001153468.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (ndf43c, also known as ndf43) lacks multiple 5' exons, but has an alternate 5' exon, an alternate internal segment and an additional exon in the 3' region, compared to variant HRG-beta1. The resulting isoform (ndf43c) is much shorter, and has alternate N- and C-termini and a different internal segment, compared to isoform HRG-beta1.
    Source sequence(s)
    AK293240, BC144446, DA805080, DC425692
    UniProtKB/TrEMBL
    B7Z1D7
    Conserved Domains (2) summary
    pfam02158
    Location:81270
    Blast Score: 916
    Neuregulin; Neuregulin family
    cd00054
    Location:3668
    Blast Score: 81
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  3. NM_001159999.1NP_001153471.1  pro-neuregulin-1, membrane-bound isoform isoform HRG-beta1b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (HRG-beta1b) has an alternate 5' exon, compared to variant HRG-beta1. The resulting isoform (HRG-beta1b, also known as type IV fetal B beta 1a) is shorter, and has a different N-terminus, compared to isoform HRG-beta1.
    Source sequence(s)
    CN603652, DA805080, EF517296, M94165, U02328
    UniProtKB/TrEMBL
    A6MW55
    UniProtKB/Swiss-Prot
    Q02297
    Conserved Domains (4) summary
    pfam02158
    Location:219614
    Blast Score: 1697
    Neuregulin; Neuregulin family
    cd05895
    Location:32106
    Blast Score: 361
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    smart00410
    Location:22108
    Blast Score: 155
    IG_like; Immunoglobulin like
    cd00054
    Location:169201
    Blast Score: 83
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  4. NM_001160001.1NP_001153473.1  pro-neuregulin-1, membrane-bound isoform isoform HRG-beta1d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (HRG-beta1d) has an alternate 5' exon and lacks two internal exons, compared to variant HRG-beta1. The resulting isoform (HRG-beta1d, also known as IV-beta 1a and type IV fetal A beta 1a) is shorter, and has a different N-terminus and lacks an internal segment, compared to isoform HRG-beta1.
    Source sequence(s)
    CN603654, DA805080, EF372273, M94165
    Consensus CDS
    CCDS55218.1
    UniProtKB/Swiss-Prot
    Q02297
    Conserved Domains (4) summary
    pfam02158
    Location:185580
    Blast Score: 1701
    Neuregulin; Neuregulin family
    cd05895
    Location:32106
    Blast Score: 360
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    smart00410
    Location:22108
    Blast Score: 155
    IG_like; Immunoglobulin like
    cd00054
    Location:135167
    Blast Score: 82
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  5. NM_001160002.1NP_001153474.1  pro-neuregulin-1, membrane-bound isoform isoform HRG-gamma2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (HRG-gamma2) lacks an internal exon and multiple 3' exons, and has an alternate 3' UTR, compared to variant HRG-beta1. The resulting isoform (HRG-gamma2, also known as gamma protein isoform 1) lacks an internal segment and is C-terminal truncated, compared to isoform HRG-beta1.
    Source sequence(s)
    AC083977, AC103675, EU363508
    UniProtKB/TrEMBL
    B0FYA7
    Conserved Domains (2) summary
    smart00410
    Location:43129
    Blast Score: 155
    IG_like; Immunoglobulin like
    cl11960
    Location:53127
    Blast Score: 322
    Ig; Immunoglobulin domain
  6. NM_001160004.1NP_001153476.1  pro-neuregulin-1, membrane-bound isoform isoform ndf43b

    See proteins identical to NP_001153476.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (ndf43b, also called ndf43-beta2) lacks an internal exon, but has an additional exon in the 3' coding region, compared to variant HRG-beta1. The resulting isoform (ndf43b) is shorter, and lacks an internal segment and has a different C-terminus, compared to isoform HRG-beta1.
    Source sequence(s)
    AC083977, BC144446, DA805080, EU363510
    UniProtKB/TrEMBL
    B0FYA9
    Conserved Domains (4) summary
    pfam02158
    Location:232421
    Blast Score: 909
    Neuregulin; Neuregulin family
    cd05895
    Location:53127
    Blast Score: 347
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    PHA03099
    Location:182271
    Blast Score: 87
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    smart00410
    Location:43129
    Blast Score: 151
    IG_like; Immunoglobulin like
  7. NM_001160005.1NP_001153477.1  pro-neuregulin-1, membrane-bound isoform isoform HRG-beta3b

    See proteins identical to NP_001153477.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (HRG-beta3b) lacks two internal exons and multiple 3' exons, and has an alternate 3' sequence including the coding region and UTR, compared to variant HRG-beta1. The resulting isoform (HRG-beta3b, also known as HRG-beta 3 protein isoform) is much shorter, and lacks an internal segment and has a different C-terminus, compared to isoform HRG-beta1.
    Source sequence(s)
    AC083977, EU359055, M94168
    UniProtKB/TrEMBL
    B0FWZ3
    UniProtKB/Swiss-Prot
    Q02297
    Conserved Domains (2) summary
    smart00410
    Location:43129
    Blast Score: 155
    IG_like; Immunoglobulin like
    cl11960
    Location:53127
    Blast Score: 328
    Ig; Immunoglobulin domain
  8. NM_001160007.1NP_001153479.1  pro-neuregulin-1, membrane-bound isoform isoform HRG-gamma3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (HRG-gamma3) lacks two internal exons and multiple 3' exons, and has an alternate 3' UTR, compared to variant HRG-beta1. The resulting isoform (HRG-gamma3, also known as gamma protein isoform 2) lacks an internal segment and is C-terminal truncated, compared to isoform HRG-beta1.
    Source sequence(s)
    AC083977, AC103675, EU363509
    UniProtKB/TrEMBL
    B0FYA8
    Conserved Domains (2) summary
    smart00410
    Location:43129
    Blast Score: 155
    IG_like; Immunoglobulin like
    cl11960
    Location:53127
    Blast Score: 313
    Ig; Immunoglobulin domain
  9. NM_001160008.1NP_001153480.1  pro-neuregulin-1, membrane-bound isoform isoform HRG-beta2b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (HRG-beta2b) lacks an internal exon and the 3' exon, but has an alternate 3' UTR, compared to variant HRG-beta1. The resulting isoform (HRG-beta2b) lacks an internal segment and is C-terminal truncated, compared to isoform HRG-beta1.
    Source sequence(s)
    AK097005, AK298132, BC006492, BQ018711
    Consensus CDS
    CCDS55219.1
    UniProtKB/Swiss-Prot
    Q02297
    UniProtKB/TrEMBL
    Q6PK61
    Related
    ENSP00000430120, OTTHUMP00000225419, ENST00000523079, OTTHUMT00000376466
    Conserved Domains (4) summary
    pfam02158
    Location:232420
    Blast Score: 904
    Neuregulin; Neuregulin family
    cd05895
    Location:53127
    Blast Score: 345
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    PHA03099
    Location:182271
    Blast Score: 87
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    smart00410
    Location:43129
    Blast Score: 149
    IG_like; Immunoglobulin like
  10. NM_004495.3NP_004486.2  pro-neuregulin-1, membrane-bound isoform isoform HRG-gamma

    See proteins identical to NP_004486.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (HRG-gamma) lacks multiple 3' exons and has an alternate 3' UTR, compared to variant HRG-beta1. The resulting isoform (HRG-gamma) is C-terminal truncated, compared to isoform HRG-beta1.
    Source sequence(s)
    AC083977, AC103675, BC144446
    UniProtKB/TrEMBL
    Q7RTW5
    Conserved Domains (2) summary
    smart00410
    Location:43129
    Blast Score: 155
    IG_like; Immunoglobulin like
    cl11960
    Location:53127
    Blast Score: 322
    Ig; Immunoglobulin domain
  11. NM_013956.3NP_039250.2  pro-neuregulin-1, membrane-bound isoform isoform HRG-beta1

    See proteins identical to NP_039250.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (HRG-beta1) is the longest transcript and encodes the longest isoform (HRG-beta1).
    Source sequence(s)
    AK097005, AK298132, BC006492, BC144446, DA805080, M94166
    Consensus CDS
    CCDS6083.1
    UniProtKB/Swiss-Prot
    Q02297
    UniProtKB/TrEMBL
    Q6PK61
    Related
    ENSP00000349275, ENST00000356819
    Conserved Domains (4) summary
    pfam02158
    Location:240635
    Blast Score: 1677
    Neuregulin; Neuregulin family
    cd05895
    Location:53127
    Blast Score: 360
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    smart00410
    Location:43129
    Blast Score: 155
    IG_like; Immunoglobulin like
    cd00054
    Location:190222
    Blast Score: 83
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  12. NM_013957.3NP_039251.2  pro-neuregulin-1, membrane-bound isoform isoform HRG-beta2

    See proteins identical to NP_039251.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (HRG-beta2) lacks an internal exon in the 3' coding region, compared to variant HRG-beta1. The resulting isoform (HRG-beta2) has identical N- and C-termini, but lacks an internal segment, compared to isoform HRG-beta1.
    Source sequence(s)
    AK097005, AK290730, AK298132, BC006492, DA805080, M94165
    Consensus CDS
    CCDS6084.1
    UniProtKB/Swiss-Prot
    Q02297
    UniProtKB/TrEMBL
    Q6PK61
    UniProtKB/TrEMBL
    Q7RTW3
    Related
    ENSP00000287842, OTTHUMP00000225420, ENST00000287842, OTTHUMT00000376467
    Conserved Domains (4) summary
    pfam02158
    Location:232627
    Blast Score: 1668
    Neuregulin; Neuregulin family
    cd05895
    Location:53127
    Blast Score: 358
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    smart00410
    Location:43129
    Blast Score: 154
    IG_like; Immunoglobulin like
    cd00054
    Location:190222
    Blast Score: 83
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  13. NM_013958.3NP_039252.2  pro-neuregulin-1, membrane-bound isoform isoform HRG-beta3

    See proteins identical to NP_039252.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (HRG-beta3, also known as GGF or GGFHFB1) lacks multiple 3' exons, and has an alternate 3' sequence including the coding region and UTR, compared to variant HRG-beta1. The resulting isoform (HRG-beta3) is much shorter, and has a different C-terminus, compared to isoform HRG-beta1.
    Source sequence(s)
    AK097005, AK298132, M94165, M94168
    UniProtKB/Swiss-Prot
    Q02297
    Conserved Domains (2) summary
    smart00410
    Location:43129
    Blast Score: 153
    IG_like; Immunoglobulin like
    cl11960
    Location:53127
    Blast Score: 333
    Ig; Immunoglobulin domain
  14. NM_013959.3NP_039253.1  pro-neuregulin-1, membrane-bound isoform isoform SMDF

    See proteins identical to NP_039253.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (SMDF) is expressed mainly in the nervous system. It lacks multiple 5' and 3' exons, but has an alternate 5' exon and an alternate 3' sequence including the coding region and UTR, compared to variant HRG-beta1. The resulting isoform (SMDF) is much shorter, and has different N- and C-termini, compared to isoform HRG-beta1.
    Source sequence(s)
    AK289927, M94168
    Consensus CDS
    CCDS6087.1
    UniProtKB/Swiss-Prot
    Q02297
    Conserved Domains (1) summary
    PHA02887
    Location:236279
    Blast Score: 83
    PHA02887; EGF-like protein; Provisional
  15. NM_013960.3NP_039254.1  pro-neuregulin-1, membrane-bound isoform isoform ndf43

    See proteins identical to NP_039254.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (ndf43) has an alternate internal segment and an additional exon in the 3' region, compared to variant HRG-beta1. The resulting isoform (ndf43) is shorter, and has a different internal segment and C-terminus, compared to isoform HRG-beta1.
    Source sequence(s)
    AK097005, AK298132, BC006492, DA805080, M94165, U02326
    Consensus CDS
    CCDS6086.1
    UniProtKB/Swiss-Prot
    Q02297
    UniProtKB/TrEMBL
    Q6PK61
    Conserved Domains (4) summary
    pfam02158
    Location:235424
    Blast Score: 904
    Neuregulin; Neuregulin family
    cd05895
    Location:53127
    Blast Score: 346
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    smart00410
    Location:43129
    Blast Score: 151
    IG_like; Immunoglobulin like
    cd00054
    Location:190222
    Blast Score: 85
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  16. NM_013962.2NP_039256.2  pro-neuregulin-1, membrane-bound isoform isoform GGF2 precursor

    See proteins identical to NP_039256.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (GGF2, also called GGFHBS5) is expressed in the nervous system and functions as a neuronal signal that promotes the proliferation and survival of the oligodendrocyte and the myelinating cell. This variant lacks two internal exons and multiple 3' exons, and has an alternate 5' exon and an alternate 3' sequence including the coding region and UTR, compared to variant HRG-beta1. The resulting isoform (GGF2) is shorter, and has different N- and C- termini as well as lacks an internal segment, compared to isoform HRG-beta1.
    Source sequence(s)
    L12260, M94165, M94168
    Consensus CDS
    CCDS47836.1
    UniProtKB/Swiss-Prot
    Q02297
    Related
    ENSP00000434640, OTTHUMP00000230603, ENST00000520407, OTTHUMT00000376412
    Conserved Domains (3) summary
    cd05895
    Location:268342
    Blast Score: 354
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    PHA02887
    Location:362405
    Blast Score: 83
    PHA02887; EGF-like protein; Provisional
    smart00410
    Location:258344
    Blast Score: 155
    IG_like; Immunoglobulin like
  17. NM_013964.3NP_039258.1  pro-neuregulin-1, membrane-bound isoform isoform HRG-alpha

    See proteins identical to NP_039258.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (HRG-alpha, also called erbB2) has an alternate internal segment, compared to variant HRG-beta1. The resulting isoform (HRG-alpha) is shorter, and has identical N- and C-termini and a different internal segment, compared to isoform HRG-beta1.
    Source sequence(s)
    AK097005, AK298132, BC006492, DA805080, M94165
    Consensus CDS
    CCDS6085.1
    UniProtKB/Swiss-Prot
    Q02297
    UniProtKB/TrEMBL
    Q6PK61
    Related
    ENSP00000343395, ENST00000338921
    Conserved Domains (4) summary
    pfam02158
    Location:235630
    Blast Score: 1662
    Neuregulin; Neuregulin family
    cd05895
    Location:53127
    Blast Score: 357
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    smart00410
    Location:43129
    Blast Score: 154
    IG_like; Immunoglobulin like
    cd00054
    Location:190222
    Blast Score: 91
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000008.11

    Range
    31639304..32765040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273486.1XP_005273543.1  

    Conserved Domains (2) summary
    pfam02158
    Location:290685
    Blast Score: 1678
    Neuregulin; Neuregulin family
    cd00054
    Location:245277
    Blast Score: 87
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  2. XM_005273485.1XP_005273542.1  

    Conserved Domains (2) summary
    pfam02158
    Location:295690
    Blast Score: 1690
    Neuregulin; Neuregulin family
    PHA02887
    Location:236279
    Blast Score: 83
    PHA02887; EGF-like protein; Provisional
  3. XM_005273487.1XP_005273544.1  

    Conserved Domains (2) summary
    pfam02158
    Location:287682
    Blast Score: 1686
    Neuregulin; Neuregulin family
    PHA03099
    Location:237326
    Blast Score: 85
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
  4. XM_006716335.1XP_006716398.1  

    Conserved Domains (1) summary
    pfam02158
    Location:15410
    Blast Score: 1635
    Neuregulin; Neuregulin family

Alternate HuRef

Genomic

  1. AC_000140.1 Alternate HuRef

    Range
    30042037..31167972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    31698276..32824231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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