SOCS7 suppressor of cytokine signaling 7 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: SOCS7provided by HGNC
Official Full Name: suppressor of cytokine signaling 7provided by HGNC
Primary source: HGNC:29846
See related: HPRD:12299; MIM:608788
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NAP4; NCKAP4

Genomic context

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Location :: 17q12

Sequence :: Chromosome: 17; NC_000017.10 (36508007..36561846)

See SOCS7 in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

LNCaP-S17 cells are resistant to exogenous IL-6-induced neuroendocrine differentiation due to increased levels of CIS/SOCS7 that block activation of JAK2-STAT3 pathways.
Title: LNCaP prostate cancer cells with autocrine interleukin-6 expression are resistant to IL-6-induced neuroendocrine differentiation due to increased expression of suppressors of cytokine signaling.
Higher mRNA expression levels of SOCS1, 3, 4 and 7 are significantly associated with earlier tumour stage and better clinical outcome in human breast cancer.
Title: Higher expression levels of SOCS 1,3,4,7 are associated with earlier tumour stage and better clinical outcome in human breast cancer.
findings show that PPAR-gamma is involved in the regulation of SOCS-7 expression by hepatitis C virus core protein genotype 3a
Title: Hepatitis C virus core protein genotype 3a increases SOCS-7 expression through PPAR-{gamma} in Huh-7 cells.
Demonstrate connection between septins/SOCS7/NCK signaling and the DNA damage response.
Title: Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7.
data suggest that SOCS7 is a potent regulator of glucose homeostasis and insulin signaling
Title: Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.
Results indicate that SOCS-7 is a dysregulator of prolactin, leptin, and growth hormone signaling and that its mode of action is a variation of SOCS protein inhibition of cytokine-inducible STAT3 and 5-mediated signal transduction.
Title: Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation.
Taken together, our data indicate that SOCS-7 interacts with vinexin and the actin cytoskeleton.
Title: The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
O14512	P00533	EGFR	HPRD	PubMed
O14512	P62993	GRB2	HPRD	PubMed
O14512	Q9Y4H2	IRS2	HPRD	PubMed
O14512	Insulin receptor substrate 4	IRS4	HPRD	PubMed
O14512	P16333	NCK1	HPRD	PubMed
O14512	P27986	PIK3R1	HPRD	PubMed
O14512	O00459	PIK3R2	HPRD	PubMed
O14512	P19174	PLCG1	HPRD	PubMed
O14512	O60504	SORBS3	HPRD	PubMed
O14512	Q71U36	TUBA1A	HPRD	PubMed
O14512	P68371	TUBB4B	HPRD	PubMed
BioGRID:119053	BioGRID:113743	CUL5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:119053	BioGRID:110770	NCK1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:119053	BioGRID:116770	SEPT6	BioGRID	PubMed	Affinity Capture-Western
BioGRID:119053	BioGRID:115475	SORBS3	BioGRID	PubMed	Two-hybrid
BioGRID:119053	BioGRID:112651	STAT3	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:119053	BioGRID:112653	STAT5A	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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ECS complex, organism-specific biosystem (from KEGG)
ECS complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
ECS complex, conserved biosystem (from KEGG)
ECS complex, conserved biosystemStructural complex; Genetic information processing; Ubiquitin system
Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Jak-STAT signaling pathway, conserved biosystem (from KEGG)
Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Leptin signaling pathway, organism-specific biosystem (from WikiPathways)
Leptin signaling pathway, organism-specific biosystemLeptin is a peptide hormone mainly synthesised and secreted from adipocytes. It is also expressed in other tissues including placenta, stomach and skeletal muscle. Leptin mediates its effects by bind...

General gene information

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Markers

D8S2282 (e-PCR)
- UniSTS:473910

D10S2448 (e-PCR)
- UniSTS:474444

G20462 (e-PCR)
- UniSTS:29023

A005S24 (e-PCR)
- UniSTS:29024

RH36905 (e-PCR)
- UniSTS:87932

Homology

Homologs of the SOCS7 gene: The SOCS7 gene is conserved in Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and mosquito.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
SH3 domain binding	NAS Non-traceable Author Statement more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
biological_process	ND No biological Data available more info
fat cell differentiation	IEA Inferred from Electronic Annotation more info
insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
intracellular signal transduction	IEA Inferred from Electronic Annotation more info
negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
protein ubiquitination	IEA Inferred from Electronic Annotation more info
regulation of growth	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info
nucleus	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: suppressor of cytokine signaling 7

Names: suppressor of cytokine signaling 7; NAP-4; SOCS-7; NCK-associated protein 4; Nck, Ash and phospholipase C binding protein; nck, Ash and phospholipase C gamma-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014598.2 → NP_055413.1 suppressor of cytokine signaling 7

Status: VALIDATED

Source sequence(s)

AB005216, AC124789, AC183084, BC128607

Consensus CDS

CCDS32637.1

UniProtKB/Swiss-Prot

O14512

Conserved Domains (2) summary

cd03741
Location:513 – 561
Blast Score: 211

SOCS_SOCS7; SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal ...

cd10388
Location:389 – 489
Blast Score: 476

SH2_SOCS7; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 PATCHES

Genomic

NW_003315948.1 Reference GRCh37.p10 PATCHES

Range

135391..189231

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p10 Primary Assembly

Range

36508007..36561846

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

32304776..32358313

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018928.1 Alternate CHM1_1.0

Range

36836934..36890403

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01031927.1 (2410..55348)	None
genomic	ABBA01031928.1	None
genomic	AC115992.13 (123195..139475)	None
genomic	AC124789.12 (3601..41162)	None
genomic	AC183084.2	None
genomic	AMYH01008362.1 (391264..444733)	None
genomic	CH471152.1	EAW60512.1
mRNA	AA233668.1	None
mRNA	AB005216.1	BAA22432.1
mRNA	AI223248.1	None
mRNA	AK094338.1	None
mRNA	AW613025.1	None
mRNA	BC121030.1	None
mRNA	BC121031.1	None
mRNA	BC128607.1	AAI28608.1
mRNA	DQ593634.1	None
other-genetic	BC167822.1	AAI67822.1