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HGF hepatocyte growth factor (hepapoietin A; scatter factor) [ Homo sapiens (human) ]

Gene ID: 3082, updated on 26-Jul-2015
Official Symbol
HGFprovided by HGNC
Official Full Name
hepatocyte growth factor (hepapoietin A; scatter factor)provided by HGNC
Primary source
HGNC:HGNC:4893
See related
Ensembl:ENSG00000019991; HPRD:00799; MIM:142409; Vega:OTTHUMG00000023804
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SF; HGFB; HPTA; F-TCF; DFNB39
Summary
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Orthologs
Location:
7q21.1
Exon count:
20
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (81699006..81770438, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (81331444..81399452, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cadherin-related family member 4-like Neighboring gene uncharacterized LOC100128317 Neighboring gene calcium channel, voltage-dependent, alpha 2/delta subunit 1 Neighboring gene uncharacterized LOC101927356 Neighboring gene uncharacterized LOC105375375

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Scatter factor (SF) attenuates the apoptosis induced by high-doses of HIV-1 gp120 in human mesangial cells (HMC) PubMed
Vpu vpu The gene expression of hepatocyte growth factor (HGF) increases in cells infected with vpu-deficient HIV-1 compared to cells infected with the wild-type virus, indicating that HIV-1 Vpu downregulates HGF protein expression PubMed

Go to the HIV-1, Human Interaction Database

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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chemoattractant activity IDA
Inferred from Direct Assay
more info
PubMed 
growth factor activity NAS
Non-traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
NOT serine-type endopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
NOT serine-type peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
blood coagulation TAS
Traceable Author Statement
more info
 
cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hepatocyte growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
epithelial to mesenchymal transition TAS
Traceable Author Statement
more info
PubMed 
hepatocyte growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
hyaluronan metabolic process IEA
Inferred from Electronic Annotation
more info
 
mitotic nuclear division NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of hydrogen peroxide-mediated programmed cell death IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of release of cytochrome c from mitochondria IDA
Inferred from Direct Assay
more info
PubMed 
organ regeneration IEA
Inferred from Electronic Annotation
more info
 
platelet activation TAS
Traceable Author Statement
more info
 
platelet degranulation TAS
Traceable Author Statement
more info
 
positive chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of myelination IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron projection regeneration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoblast differentiation NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter NAS
Non-traceable Author Statement
more info
PubMed 
NOT proteolysis NAS
Non-traceable Author Statement
more info
PubMed 
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
platelet alpha granule lumen TAS
Traceable Author Statement
more info
 
Preferred Names
hepatocyte growth factor
Names
fibroblast-derived tumor cytotoxic factor
hepatopoeitin-A
hepatopoietin-A
lung fibroblast-derived mitogen

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016274.1 RefSeqGene

    Range
    5001..73009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000601.4NP_000592.3  hepatocyte growth factor isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_000592.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). To date, experimental evidence for cleavage of the proprotein into two mature chains has been shown only for isoform 1.
    Source sequence(s)
    BM153501, BU533235, M29145, M73240
    Consensus CDS
    CCDS5597.1
    UniProtKB/Swiss-Prot
    P14210
    Conserved Domains (4) summary
    smart00020
    Location:494716
    Tryp_SPc; Trypsin-like serine protease
    cd00108
    Location:208289
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:39122
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
    cd00190
    Location:495719
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_001010931.1NP_001010931.1  hepatocyte growth factor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001010931.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' exons but includes an alternate 3' exon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1. Isoform 2, also named NK2, has been shown to act as a competitive antagonist to active hepatocyte growth factor for the c-Met receptor.
    Source sequence(s)
    BM971901, BU533235, L02931
    Consensus CDS
    CCDS47627.1
    UniProtKB/Swiss-Prot
    P14210
    Related
    ENSP00000389854, OTTHUMP00000206711, ENST00000444829, OTTHUMT00000337134
    Conserved Domains (2) summary
    cd00108
    Location:208289
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:39122
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
  3. NM_001010932.1NP_001010932.1  hepatocyte growth factor isoform 3 precursor

    See identical proteins and their annotated locations for NP_001010932.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame segment in the middle coding region, compared to variant 1. The resulting isoform 3 lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    BM153501, BU533235, M73240
    Consensus CDS
    CCDS47626.1
    UniProtKB/Swiss-Prot
    P14210
    Related
    ENSP00000391238, OTTHUMP00000206713, ENST00000457544, OTTHUMT00000337136
    Conserved Domains (4) summary
    smart00020
    Location:489711
    Tryp_SPc; Trypsin-like serine protease
    cd00108
    Location:203284
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:39122
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
    cd00190
    Location:490714
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  4. NM_001010933.1NP_001010933.1  hepatocyte growth factor isoform 4 precursor

    See identical proteins and their annotated locations for NP_001010933.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an internal in-frame segment and multiple 3' exons but includes an alternate 3' exon, compared to variant 1. The resulting protein (isoform 4) lacks an internal segment and has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC022308, BM971901, BU533235, L02931
    Consensus CDS
    CCDS47628.1
    UniProtKB/Swiss-Prot
    P14210
    Related
    ENSP00000408270, OTTHUMP00000206710, ENST00000453411, OTTHUMT00000337133
    Conserved Domains (2) summary
    cd00108
    Location:203284
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:39122
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
  5. NM_001010934.1NP_001010934.1  hepatocyte growth factor isoform 5 precursor

    See identical proteins and their annotated locations for NP_001010934.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks multiple 3' exons but has an alternate 3' segment, compared to variant 1. The resulting protein (isoform 5) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    BC063485, BU533235, U46010
    Consensus CDS
    CCDS47629.1
    UniProtKB/Swiss-Prot
    P14210
    Related
    ENSP00000413829, OTTHUMP00000206712, ENST00000423064, OTTHUMT00000337135
    Conserved Domains (2) summary
    cd00108
    Location:126207
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:39122
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

    Range
    81699006..81770438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516115.1XP_011514417.1  

    See identical proteins and their annotated locations for XP_011514417.1

    UniProtKB/Swiss-Prot
    P14210
    Conserved Domains (4) summary
    smart00020
    Location:489711
    Tryp_SPc; Trypsin-like serine protease
    cd00108
    Location:203284
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:39122
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
    cd00190
    Location:490714
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_006715956.2XP_006716019.1  

    See identical proteins and their annotated locations for XP_006716019.1

    UniProtKB/Swiss-Prot
    P14210
    Related
    ENSP00000222390, OTTHUMP00000161349, ENST00000222390, OTTHUMT00000253315
    Conserved Domains (4) summary
    smart00020
    Location:494716
    Tryp_SPc; Trypsin-like serine protease
    cd00108
    Location:208289
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:39122
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
    cd00190
    Location:495719
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    81261794..81329511
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)