HGF hepatocyte growth factor (hepapoietin A; scatter factor) [Homo sapiens (human)] - Gene

Summary

Go to the top of the page Help

Official Symbol: HGFprovided by HGNC
Official Full Name: hepatocyte growth factor (hepapoietin A; scatter factor)provided by HGNC
Primary source: HGNC:4893
See related: Ensembl:ENSG00000019991; HPRD:00799; MIM:142409; Vega:OTTHUMG00000023804
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SF; HGFB; HPTA; F-TCF; DFNB39
Summary: Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Genomic context

Go to the top of the page Help

Location :: 7q21.1

Sequence :: Chromosome: 7; NC_000007.13 (81331444..81399452, complement)

See HGF in Epigenomics, MapViewer

Chromosome 7 - NC_000007.13 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Met kinetic signature derived from the response to HGF/SF in a cellular model predicts breast cancer patient survival
Title: Met kinetic signature derived from the response to HGF/SF in a cellular model predicts breast cancer patient survival.
Data suggest that HLX1 (H2.0-like homeo box 1) is downstream mediator of HGF-induced cell survival, cell proliferation, and invasive properties of trophoblast cells; thus, both HGF and HLX1 appear to be involved in normal placental development.
Title: Hepatocyte growth factor regulates HLX1 gene expression to modulate HTR-8/SVneo trophoblast cells.
Differences in stromal cell ability to induce angiogenesis are a result of differences in the secretion of HGF.
Title: Analysis of stromal cell secretomes reveals a critical role for stromal cell-derived hepatocyte growth factor and fibronectin in angiogenesis.
Studies indicate that EGFR signaling in EGFR-mutant lung cancer and hepatocyte growth factor (HGF) ligand-triggered bypass signals (HGF-Met and EGFR ligands-EGFR) must be simultaneously blocked to avoid the resistance.
Title: Ligand-triggered resistance to molecular targeted drugs in lung cancer: roles of hepatocyte growth factor and epidermal growth factor receptor ligands.
S1PR1 and ITGB4 transactivation are rate-limiting events in the transduction of HGF signals via a dynamic c-Met complex resulting in enhanced EC barrier integrity
Title: Critical role of S1PR1 and integrin β4 in HGF/c-Met-mediated increases in vascular integrity.
study indicated that JNK and P38 MAPK pathways are required in HGF-induced biological responses in hDPCs: cell proliferation, differentiation, and migration.
Title: JNK/P38 mitogen-activated protein kinase used for hepatocyte growth factor-induced proliferation, differentiation, and migration in human dental papilla cells.
HGF is upregulated in POEMS syndrome. Elevation of HGF levels is not secondary to VEGF overproduction.
Title: Multiple angiogenetic factors are upregulated in POEMS syndrome.
In a spinocerebellar ataxia type 7 transgenic mouse model, overexpression of HGF attenuates degeneration of Purkinje cells and Bergmann glia.
Title: Overexpression of HGF attenuates the degeneration of Purkinje cells and Bergmann glia in a knockin mouse model of spinocerebellar ataxia type 7.
High hepatocyte growth factor is associated with renal cell carcinoma progression.
Title: Changes in circulating pro-angiogenic cytokines, other than VEGF, before progression to sunitinib therapy in advanced renal cell carcinoma patients.
There was significant correlation among tumor cell-derived HGF, cell proliferation and microvessel proliferation in gliomas. HGF might influence tumor progression by modulating the cell growth, migration and chemoresistance to drugs.
Title: Tumor-derived hepatocyte growth factor is associated with poor prognosis of patients with glioma and influences the chemosensitivity of glioma cell line to cisplatin in vitro.

Submit: New GeneRIF Correction See all (418)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Deafness, autosomal recessive 39

MIM: 608265

Genetic Testing Registry

Summary from GeneReviews: Deafness and Hereditary Hearing Loss Overview

Hereditary hearing loss and deafness may be conductive, sensorineural, or a combination of both; syndromic (associated with malformations of the external ear or other organs or with medical problems involving other organ systems) or nonsyndromic (no associated visible abnormalities of the external ear or any related medical problems); and prelingual (before language develops) or postlingual (after language develops).

Diagnosis Testing

Genetic forms of hearing loss must be distinguished from acquired (non-genetic) causes of hearing loss. The genetic forms of hearing loss are diagnosed by otologic, audiologic, and physical examination, family history, ancillary testing (e.g., CT examination of the temporal bone), and molecular genetic testing. Molecular genetic testing, available in clinical laboratories for many types of syndromic and nonsyndromic deafness, plays a prominent role in diagnosis and genetic counseling.

Genetic Counseling

Hereditary hearing loss can be inherited in an autosomal dominant, autosomal recessive, or X-linked recessive manner, as well as by mitochondrial inheritance. Genetic counseling and risk assessment depend on accurate determination of the specific genetic diagnosis. In the absence of a specific diagnosis, empiric recurrence risk figures, coupled with GJB2 and GJB6 molecular genetic testing results, can be used for genetic counseling.

References

PMID: 20301607

HIV-1 protein interactions

Go to the top of the page Help

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Scatter factor (SF) attenuates the apoptosis induced by high-doses of HIV-1 gp120 in human mesangial cells (HMC)	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Source	Pubs	Description
NP_000592.3	NP_000236.2	MET	BIND	PubMed	HGF interacts with Met.
NP_000592.3			BIND	PubMed	HGF interacts with Copper(II).
P14210	P05452	CLEC3B	HPRD	PubMed
P14210	P03951	F11	HPRD	PubMed
P14210	P02751	FN1	HPRD	PubMed
P14210	P14210	HGF	HPRD	PubMed
P14210	Q04756	HGFAC	HPRD	PubMed
P14210	P05981	HPN	HPRD	PubMed
P14210	P03952	KLKB1	HPRD	PubMed
P14210	P80188	LCN2	HPRD	PubMed
P14210	P08581	MET	HPRD	PubMed
P14210	P00749	PLAU	HPRD	PubMed
P14210	P18827	SDC1	HPRD	PubMed
P14210	P34741	SDC2	HPRD	PubMed
P14210	Q9Y5Y6	ST14	HPRD	PubMed
P14210	P04004	VTN	HPRD	PubMed
BioGRID:109330	BioGRID:112978	CLEC3B	BioGRID	PubMed	Reconstituted Complex
BioGRID:109330	BioGRID:119613	HDAC7	BioGRID	PubMed	Negative Genetic
BioGRID:109330	BioGRID:109330	HGF	BioGRID	PubMed	Co-crystal Structure
BioGRID:109330	BioGRID:115114	KIAA0101	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109330	BioGRID:110391	MET	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
	NP_003864.2	NRP1	BIND	PubMed	NRP1 (Npn-1) interacts with HGF. This interaction was modeled on a demonstrated interaction between rat NRP1 and human HGF.
BioGRID:109330	BioGRID:112284	SDC1	BioGRID	PubMed	Reconstituted Complex
BioGRID:109330	BioGRID:112285	SDC2	BioGRID	PubMed	Reconstituted Complex

Pathways from BioSystems

Go to the top of the page Help

Arf6 signaling events, organism-specific biosystem (from Pathway Interaction Database)
Arf6 signaling events, organism-specific biosystem
Arf6 signaling events
Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
Direct p53 effectors, organism-specific biosystem
Direct p53 effectors
FGF signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
FGF signaling pathway, organism-specific biosystem
FGF signaling pathway
Focal Adhesion, organism-specific biosystem (from WikiPathways)
Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, organism-specific biosystem (from KEGG)
Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, conserved biosystem (from KEGG)
Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Interleukin-7 signaling, organism-specific biosystem (from REACTOME)
Interleukin-7 signaling, organism-specific biosystemInterleukin-7 (IL7) is produced primarily by T zone fibroblastic reticular cells found in lymphoid organs, and also expressed by non-hematopoietic stromal cells present in other tissues including the...
Malaria, organism-specific biosystem (from KEGG)
Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
Malaria, conserved biosystem (from KEGG)
Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
Melanoma, organism-specific biosystem (from KEGG)
Melanoma, organism-specific biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
Melanoma, conserved biosystem (from KEGG)
Melanoma, conserved biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
Platelet degranulation, organism-specific biosystem (from REACTOME)
Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
Prostate Cancer, organism-specific biosystem (from WikiPathways)
Prostate Cancer, organism-specific biosystem
Prostate Cancer
Proteoglycans in cancer, organism-specific biosystem (from KEGG)
Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Proteoglycans in cancer, conserved biosystem (from KEGG)
Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Renal cell carcinoma, organism-specific biosystem (from KEGG)
Renal cell carcinoma, organism-specific biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
Renal cell carcinoma, conserved biosystem (from KEGG)
Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...
Signaling by Interleukins, organism-specific biosystem (from REACTOME)
Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Signaling events mediated by TCPTP, organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by TCPTP, organism-specific biosystem
Signaling events mediated by TCPTP
Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem (from WikiPathways)
Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem
Signaling of Hepatocyte Growth Factor Receptor
Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem (from Pathway Interaction Database)
Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem
Stabilization and expansion of the E-cadherin adherens junction
Syndecan-1-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
Syndecan-1-mediated signaling events, organism-specific biosystem
Syndecan-1-mediated signaling events

General gene information

Go to the top of the page Help

Markers

RH47062 (e-PCR)
- UniSTS:75781

G66820 (e-PCR)
- UniSTS:166661

SHGC-31157 (e-PCR)
- UniSTS:24590

STS-AA015815 (e-PCR)
- UniSTS:77839

D7S3046 (e-PCR)
- UniSTS:8215

D7S804 (e-PCR), detects polymorphism
- UniSTS:10017

SHGC-84463 (e-PCR)
- UniSTS:104756

Hgf (e-PCR), detects polymorphism
- UniSTS:256371

D7S644 (e-PCR), detects polymorphism
- UniSTS:39592

Hgf (e-PCR), detects polymorphism
- UniSTS:143341

Hgf (e-PCR), detects polymorphism
- UniSTS:143342

D7S804 (e-PCR), detects polymorphism
- UniSTS:83193

D7S2748 (e-PCR)
- UniSTS:69631

Genotypes

See HGF SNP Geneview Report
See HGF SNP Genotype Report
See HGF SNP Variation Viewer Report

Homology

Homologs of the HGF gene: The HGF gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
chemoattractant activity	IDA Inferred from Direct Assay more info
growth factor activity	NAS Non-traceable Author Statement more info	PubMed
identical protein binding	IPI Inferred from Physical Interaction more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
NOT serine-type endopeptidase activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
activation of MAPK activity	IEA Inferred from Electronic Annotation more info
blood coagulation	TAS Traceable Author Statement more info
cell chemotaxis	IDA Inferred from Direct Assay more info
cellular response to hepatocyte growth factor stimulus	IDA Inferred from Direct Assay more info
epithelial to mesenchymal transition	TAS Traceable Author Statement more info	PubMed
hepatocyte growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info
liver development	IEA Inferred from Electronic Annotation more info
mitosis	NAS Non-traceable Author Statement more info	PubMed
myoblast proliferation	IEA Inferred from Electronic Annotation more info
negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info
negative regulation of hydrogen peroxide-mediated programmed cell death	IDA Inferred from Direct Assay more info
negative regulation of release of cytochrome c from mitochondria	IDA Inferred from Direct Assay more info
organ regeneration	IEA Inferred from Electronic Annotation more info
platelet activation	TAS Traceable Author Statement more info
platelet degranulation	TAS Traceable Author Statement more info
positive chemotaxis	IDA Inferred from Direct Assay more info
positive regulation of DNA biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell migration	IDA Inferred from Direct Assay more info
positive regulation of osteoblast differentiation	NAS Non-traceable Author Statement more info
positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info
positive regulation of phosphatidylinositol 3-kinase cascade	IDA Inferred from Direct Assay more info
positive regulation of transcription from RNA polymerase II promoter	NAS Non-traceable Author Statement more info
NOT proteolysis	NAS Non-traceable Author Statement more info	PubMed
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
extracellular region	TAS Traceable Author Statement more info
extracellular space	IEA Inferred from Electronic Annotation more info
platelet alpha granule lumen	TAS Traceable Author Statement more info

General protein information

Go to the top of the page Help

Preferred Names: hepatocyte growth factor

Names: hepatocyte growth factor; hepatopoeitin-A; hepatopoietin-A; lung fibroblast-derived mitogen; fibroblast-derived tumor cytotoxic factor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016274.1 RefSeqGene

Range

5001..73009

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000601.4 → NP_000592.3 hepatocyte growth factor isoform 1 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). To date, experimental evidence for cleavage of the proprotein into two mature chains has been shown only for isoform 1.

Source sequence(s)

BM153501, BU533235, M29145, M73240

Consensus CDS

CCDS5597.1

UniProtKB/Swiss-Prot

P14210

Conserved Domains (3) summary

cd00108
Location:126 – 207
Blast Score: 306

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00129
Location:39 – 122
Blast Score: 235

PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...

cd00190
Location:495 – 719
Blast Score: 508

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NM_001010931.1 → NP_001010931.1 hepatocyte growth factor isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks multiple 3' exons but includes an alternate 3' exon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1. Isoform 2, also named NK2, has been shown to act as a competitive antagonist to active hepatocyte growth factor for the c-Met receptor.

Source sequence(s)

BM971901, BU533235, L02931

Consensus CDS

CCDS47627.1

UniProtKB/Swiss-Prot

P14210

Related

ENSP00000389854, OTTHUMP00000206711, ENST00000444829, OTTHUMT00000337134

Conserved Domains (2) summary

cd00108
Location:208 – 289
Blast Score: 301

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00129
Location:39 – 122
Blast Score: 221

PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
NM_001010932.1 → NP_001010932.1 hepatocyte growth factor isoform 3 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an in-frame segment in the middle coding region, compared to variant 1. The resulting isoform 3 lacks an internal segment, compared to isoform 1.

Source sequence(s)

BM153501, BU533235, M73240

Consensus CDS

CCDS47626.1

UniProtKB/Swiss-Prot

P14210

Related

ENSP00000391238, OTTHUMP00000206713, ENST00000457544, OTTHUMT00000337136

Conserved Domains (3) summary

cd00108
Location:203 – 284
Blast Score: 304

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00129
Location:39 – 122
Blast Score: 235

PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...

cd00190
Location:490 – 714
Blast Score: 508

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NM_001010933.1 → NP_001010933.1 hepatocyte growth factor isoform 4 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an internal in-frame segment and multiple 3' exons but includes an alternate 3' exon, compared to variant 1. The resulting protein (isoform 4) lacks an internal segment and has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

BC022308, BM971901, BU533235, L02931

Consensus CDS

CCDS47628.1

UniProtKB/Swiss-Prot

P14210

Related

ENSP00000408270, OTTHUMP00000206710, ENST00000453411, OTTHUMT00000337133

Conserved Domains (2) summary

cd00108
Location:203 – 284
Blast Score: 300

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00129
Location:39 – 122
Blast Score: 220

PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
NM_001010934.1 → NP_001010934.1 hepatocyte growth factor isoform 5 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks multiple 3' exons but has an alternate 3' segment, compared to variant 1. The resulting protein (isoform 5) has a distinct and shorter C-terminus, compared to isoform 1.

Source sequence(s)

BC063485, BU533235, U46010

Consensus CDS

CCDS47629.1

UniProtKB/Swiss-Prot

P14210

Related

ENSP00000413829, OTTHUMP00000206712, ENST00000423064, OTTHUMT00000337135

Conserved Domains (2) summary

cd00108
Location:126 – 207
Blast Score: 316

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00129
Location:39 – 122
Blast Score: 219

PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000007.13 Reference GRCh37.p10 Primary Assembly

Range

81331444..81399452, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000139.1 Alternate HuRef

Range

75935402..76003191, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CRA_TCAGchr7v2

Genomic

AC_000068.1 Alternate CRA_TCAGchr7v2

Range

80663506..80731238, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018918.1 Alternate CHM1_1.0

Range

84639539..84707267, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AACC02000015.1 (9844171..9911903)	None
genomic	ABBA01058066.1 (331547..351709)	None
genomic	ABBA01058067.1	None
genomic	AC004960.1	AAC71655.1
genomic	AMYH01017648.1 (191968..259696)	None
genomic	AY246560.1	AAO61091.1
genomic	CH236949.1	EAL24189.1
genomic	CH471091.2	EAW76992.1
		EAW76993.1
genomic	D90334.2	BAA14348.1
genomic	M75971.1	AAG53459.1
genomic	M75983.1	AAG53460.1
genomic	M75984.1	None
mRNA	AB208900.1	BAD92137.1
mRNA	AK291674.1	BAF84363.1
mRNA	AK313694.1	None
mRNA	BC022308.1	AAH22308.1
mRNA	BC063485.1	AAH63485.1
mRNA	BC105797.1	AAI05798.1
mRNA	BC130284.1	AAI30285.1
mRNA	BC130286.1	AAI30287.1
mRNA	BM153501.1	None
mRNA	BM971901.1	None
mRNA	BU533235.1	None
mRNA	FJ830861.1	ACX45437.1
mRNA	FJ830862.1	ACX45438.1
mRNA	L02931.1	AAA52649.1
mRNA	M29145.1	AAA52650.1
mRNA	M55379.1	None
mRNA	M60718.1	AAA52648.1
mRNA	M73239.1	AAA64239.1
mRNA	M73240.1	AAA64297.1
mRNA	M77227.1	AAA35980.1
mRNA	U46010.1	AAC50539.1
mRNA	X16323.1	CAA34387.1
mRNA	X57574.1	CAA40802.1
other-genetic	HQ258511.1	ADR83265.1