HUNK hormonally up-regulated Neu-associated kinase [Homo sapiens] - Gene

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Summary

Official Symbol: HUNKprovided by HGNC
Official Full Name: hormonally up-regulated Neu-associated kinaseprovided by HGNC
Primary source: HGNC:13326
See related: Ensembl:ENSG00000142149; HPRD:09410; MIM:606532; Vega:OTTHUMG00000085019
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

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Genomic context

Location :: 21q22.1

Sequence :: Chromosome: 21; NC_000021.8 (33245628..33376377)

See HUNK in Epigenomics, MapViewer

Chromosome 21 - NC_000021.8 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Hunk is required for HER2/neu-induced mammary tumorigenesis
Title: Hunk is required for HER2/neu-induced mammary tumorigenesis.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Data show that HUNK reconstitution in basal breast cancer cell lines prevented protein phosphatase 2-A (PP2A from binding to CFL-1.
Title: HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1.
a gene expression signature that distinguishes Hunk-wild type from Hunk-deficient tumors predicts clinical outcome in women with breast cancer
Title: The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis.
Overproduction of MAK-V/Hunk in human breast cancer may be used fore more precise molecular typing.
Title: [Proteinkinase MAK-V/Hunk as a possible dianostic and prognostic marker of human breast carcinoma].

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8.

Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.

Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
P57058	Q15276	RABEP1		HPRD	PubMed
BioGRID:119035	BioGRID:114583	RABEP1		BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
multicellular organismal development	TAS Traceable Author Statement more info	PubMed
signal transduction	TAS Traceable Author Statement more info	PubMed

General protein information

Preferred Names: hormonally up-regulated neu tumor-associated kinase

Names: hormonally up-regulated neu tumor-associated kinase; B19; serine/threonine protein kinase MAK-V; serine/threonine-protein kinase MAK-V; hormonally upregulated Neu-associated kinase; hormonally upregulated neu tumor-associated kinase

NP_055401.1

EC 2.7.11.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014586.1 → NP_055401.1 hormonally up-regulated neu tumor-associated kinase

Status: VALIDATED

Source sequence(s)

AJ271722

Consensus CDS

CCDS13610.1

UniProtKB/Swiss-Prot

P57058

Related

ENSP00000270112, OTTHUMP00000107427, ENST00000270112, OTTHUMT00000192782

Conserved Domains (2) summary

smart00220
Location:61 – 320
Blast Score: 774

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl09925
Location:66 – 320
Blast Score: 573

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000021.8 Reference GRCh37.p5 Primary Assembly

Range

33245628..33376377

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000153.1 Alternate HuRef

Range

18704976..18784354

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AP000256.1 (1099..32434)	None
genomic	AP000257.1	None
genomic	AP000258.1	None
genomic	AP000259.1	None
genomic	AP000260.1	None
genomic	CH471079.2	EAX09883.1
mRNA	AF086072.1	None
mRNA	AJ271722.1	CAB71146.1
other-genetic	BC156532.1	AAI56533.1
other-genetic	BC172525.1	AAI72525.1